Derek W. Bartlett

Derek W. Bartlett, PhD is an Assistant Professor in the Division of Pharmacotherapy and Experimental Therapeutics at the UNC School of Medicine, University of North Carolina at Chapel Hill. He is also a member of the UNC Lineberger Comprehensive Cancer Center, focusing on innovative approaches to improve drug discovery and development.

• Role: Assistant Professor
• Current Affiliation: UNC School of Medicine
• Research Center: UNC Lineberger Comprehensive Cancer Center

Research interests center on quantitative systems pharmacology modeling and microfluidic perfusion systems, aiming to replace animal models in translational drug discovery. His work explores functional precision oncology through in vitro/ex vivo drug testing and pharmacokinetic-pharmacodynamic (PK-PD) modeling, with applications in protein degradation, siRNA delivery, and microfluidic platforms.

Recent publications highlight advancements in T-cell imaging via PET tracers, ClpP agonist optimization using microfluidic systems, and computational modeling for oncology pharmacokinetics. Earlier works address siRNA nanoparticles, IDO1 inhibitors, and fluorescent imaging probes.