David Swan

David Swan is a Senior Lecturer in Biochemistry and Genetics at the University of Sunderland's School of Medicine, where he serves as the theme lead for immunology in Phase 1 Medicine. He teaches through lectures, workshops, and problem-based learning while providing pastoral support to medical students. His academic profile was last updated August 18, 2025, confirming his active status at the institution.

Dr. Swan's research focuses on immunology, particularly the genetic causes and molecular mechanisms of primary immunodeficiencies and autoimmune disorders. His work investigates monogenic disorders causing immunodeficiency and immune dysregulation, autoimmunity mechanisms, and therapies to restore self-tolerance in autoimmune patients. Key research areas include control of lymphocyte migration, signaling in lymphocyte development, and regulation of T cell responses by dendritic cells.

His publication record shows consistent scholarly output from 2008-2024, with recent work (2023-2024) focusing on NUDCD3 deficiency causing SCID and Omenn syndrome, single-cell analysis of immune dysregulation in rheumatoid arthritis, and validation of melanoma prognostic biomarkers. These publications demonstrate his expertise spanning immunogenetics, autoimmune disease mechanisms, and translational immunology applications.

Dr. Swan has collaborated extensively with leading researchers in immunology, including Sophie Hambleton, Karin Engelhardt, and Andrew Gennery, contributing to high-impact publications in journals including Science Immunology, Nature Communications, and Blood. His work often involves international collaborations and utilizes advanced techniques like whole exome sequencing and single-cell analysis.

Based in the Murray Library (Room 302) at the University of Sunderland, Dr. Swan maintains an active research program while fulfilling his teaching responsibilities in the medical curriculum, particularly in immunology topics across multiple years of the MBChB Medicine program.