معرفی
Clifford Woolf serves as Professor of Neurobiology and Neurology at Harvard Medical School and Director of the F.M. Kirby Neurobiology Center at Boston Children's Hospital. His research focuses on adaptive and maladaptive neuronal plasticity in sensory and motor systems, particularly in pain mechanisms, regeneration, and neurodegenerative diseases.
His primary research areas include neuro-immune interactions, transcriptional regulation of pain pathways, axon regeneration, and neurodegeneration. The Woolf laboratory employs multidisciplinary approaches spanning stem cell biology, molecular/cellular techniques, electrophysiology, neuroanatomy, behavior, and genetics. Current projects investigate transcriptional control of pain receptors, intracellular signaling cascades in nerve injury, immune-neuron crosstalk, and patient-derived neuron models for disease screening. The lab actively collaborates with academic institutions and pharmaceutical companies to identify novel analgesic and neuroprotective targets.
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As Director of the F.M. Kirby Neurobiology Center, Dr. Woolf leads research using induced pluripotent stem cell (iPSC) technology to reprogram patient fibroblasts into sensory and motor neurons for studying pain and motor neuron diseases. The center is an integral part of the Harvard Stem Cell Institute and develops functional genomic strategies for identifying disease-modifying genes and therapeutic targets.
