معرفی
Elizabeth Engle is a Professor of Neurology and Ophthalmology at Harvard Medical School, an Investigator of the Howard Hughes Medical Institute, and an Associate Member of the Broad Institute of MIT and Harvard. At Boston Children's Hospital, she holds roles in the Departments of Neurology, Ophthalmology, and Medicine (Genetics), and is affiliated with the F.M. Kirby Neurobiology Center and The Manton Center for Orphan Disease Research. Her research focuses on congenital disorders of eye and face movement, identifying genetic causes and molecular mechanisms underlying cranial motor neuron development. She has pioneered studies on disorders like CFEOM and Duane syndrome, leveraging mouse and zebrafish models.
Education: B.A. from Middlebury College (1985), M.D. from Johns Hopkins (1985), followed by residencies in Pediatrics, Neuropathology, and Neurology. She trained under Louis Kunkel and Alan Beggs before establishing her lab in 1997.
Research Interests: Cranial motor neuron development, genetic etiologies of congenital cranial dysinnervation disorders (CCDDs), and molecular pathways governing axon guidance. Her lab combines genomic sequencing, stem cell differentiation, and in vivo/in vitro models to study disorders such as CFEOM and Moebius syndrome. Recent work includes non-coding variant analysis and protein binding microarrays.
Publications highlight advancements in genetic screening, zebrafish models, and cellular mechanisms of axon growth. Awards include the E. Mead Johnson Award and Sidney Carter Award, recognizing her contributions to pediatric research and neurology.
Advising and Grants: Engle mentors students and researchers, though specific grant details are not specified. Her lab collaborates across institutions to address neurodevelopmental and neurodegenerative mechanisms. Clinical work includes consulting on rare cranial nerve disorders.
Labs/Teams: The Engle Lab at Boston Children’s Hospital, part of the F.M. Kirby Neurobiology Center, focuses on translational research bridging genetics and clinical practice.
