Christoph Fahlke

Prof. Dr. Christoph Fahlke is a faculty member at the Institute of Molecular and Cellular Physiology at Heinrich Heine University Düsseldorf. His research focuses on understanding the molecular mechanisms of ion transport across cell membranes, particularly in the context of ion channels and transporters crucial to brain function and human diseases.

Key research areas include:

• Investigating CIC anion channels and transporters
• Studying SLC26 multifunctional anion transporters
• Analyzing neuronal and glial glutamate transporters

His work employs cellular electrophysiology (patch clamp, microelectrode techniques), fluorometric approaches, radiotracer flux studies, heterologous expression systems (mammalian cells, Xenopus oocytes), and mouse models to explore how dysfunction in these proteins leads to neurological and metabolic disorders. Publications highlight studies on mutations in CLCN1, BSND, and CACNA1D genes linked to myotonia congenita, Bartter syndrome, and aldosteronism.