James Adjaye

James Adjaye is a Professor and Director of the Institute for Stem Cell Research and Regenerative Medicine (ISRM) at Heinrich Heine University Düsseldorf. His research focuses on using induced pluripotent stem cells (iPSCs) to model neurodegenerative diseases such as Alzheimer's Disease (AD) and Nijmegen Breakage Syndrome (NBS), with a specific emphasis on systems biology approaches for uncovering disease mechanisms.

• FP7-funded AgedBrainSYSBIO project (2013-2017): Studied sporadic Late Onset AD using iPSCs
• Investigated TREM2 p.R47H mutation and CR1 gene copy number variation in AD
• Research on NBS involving DNA damage repair and neuroinflammation

His methodologies include 2D/3D neuronal differentiation, transcriptome analysis, and secretome profiling. While scientific awards and student supervision details are not explicitly mentioned, his work demonstrates interdisciplinary collaboration in genetics, molecular biology, and regenerative medicine.