Alessandro Prigione

Alessandro Prigione is a Professor at the Department of General Pediatrics, Heinrich Heine University Düsseldorf, leading the Stem Cell Metabolism research group. His work focuses on bridging human induced pluripotent stem cell (iPSC)-based neuronal disease modeling with mitochondrial metabolism to address neurodegenerative diseases in children.

• Key affiliations: University Children’s Hospital Düsseldorf, Heinrich Heine University

Research Interests:

• Investigating mitochondrial disorders such as Leigh syndrome and Huntington’s disease in early-onset neurodegeneration.
• Utilizing patient-derived iPSCs to generate neuronal/glial cells and cerebral organoids for disease-specific modeling.
• Identifying therapeutic compounds through high-throughput screenings targeting mitochondrial and neuronal function.
• Integrating CRISPR/Cas9 genome engineering, mitochondrial assays, and high-content analysis for mechanistic studies.

Lab & Collaborations:

• His lab develops innovative models for mitochondrial diseases, emphasizing metabolic coupling in human neurons and astrocytes.
• Collaborations include institutions like the Max Planck Institute for Molecular Genetics and Charité Universitätsmedizin Berlin.