معرفی
Chris Tate is a Research Professor at the University of Cambridge, affiliated with the MRC Laboratory of Molecular Biology. His laboratory specializes in determining the structures of G protein-coupled receptors (GPCRs) using x-ray crystallography and cryo-EM, with a particular focus on understanding solute translocation and receptor signaling processes.
- Developed rational mutagenesis techniques to improve GPCR thermostability
- Engineered "mini-G proteins" to determine active-state structures
- Structural studies of β1-adrenergic receptor, adenosine A2A receptor, and serotonin 5HT1B receptor
- Pioneering work in GPCR-G protein coupling mechanisms
The lab's research has significantly advanced the understanding of ligand efficacy and G protein specificity in receptor signaling. Their work has applications in drug development targeting GPCRs, which are key pharmaceutical targets for conditions like cardiovascular diseases and asthma.
Group members include Qingchao Chen, Rosalyn Cheng, David Favara, Anna Hall, Jade Li, Yue Ren, and Malcolm Weir. Contact information: cgt@mrc-lmb.cam.ac.uk
