معرفی
Daniel Nietlispach is Professor and NMR Facility Manager in the Department of Biochemistry, University of Cambridge. He leads the Nietlispach Group, whose research centres on the structural biology and conformational dynamics of integral membrane proteins, with particular emphasis on G-protein-coupled receptors (GPCRs) and microbial rhodopsins.
Research Interests
- Conformational plasticity and dynamics of seven-helical membrane proteins
- GPCR signal transduction mechanisms investigated by solution- and solid-state NMR
- Role of lipid environment in modulating membrane protein function
- Methodological advances in NMR for membrane protein studies
The group employs a wide range of isotope-labelling strategies, membrane-mimetic systems, and cutting-edge NMR techniques to dissect the agonist-dependent conformational landscapes of receptors such as the β1-adrenergic receptor.
Publications & Scientific Impact
Over the past decade, Prof. Nietlispach has published extensively on GPCR conformational dynamics, membrane protein structure determination, and NMR methodology. Key contributions include the first solution NMR structure of the seven-helix transmembrane receptor sensory rhodopsin II and seminal studies on partial agonism and ligand efficacy at β-adrenergic receptors.
Awards & Funding
No specific prizes or medals are listed in the provided material; however, continuous funding and publication output indicate sustained research support.
Group & Facilities
As NMR Facility Manager, Daniel oversees a multi-instrument NMR suite that supports the entire Department of Biochemistry and collaborators across Cambridge. The Nietlispach Group actively welcomes enquiries from prospective interns, undergraduate researchers, PhD students and post-doctoral researchers.
