معرفی
Chris Malarkey serves as a Professor in the Rueckert-Hartman College for Health Professions at Regis University, with primary responsibilities in the School of Pharmacy. His academic career integrates advanced biochemical research with innovative discussion-based pedagogy focused on critical analysis of scientific assumptions in physical sciences education.
Dr. Malarkey completed graduate studies in chemistry where he taught undergraduate and graduate courses across general, organic, physical chemistry and biochemistry disciplines. He subsequently pursued postdoctoral training at the University of Colorado School of Medicine, instructing biochemical concepts to graduate students and medical students.
His laboratory investigates the transcription factor Sox2 through two major research trajectories: (1) examining Sox2's binding interactions with bacterial lipopolysaccharides (LPS) and their role in gastric cancer progression, including discovery of an LPS-binding motif within Sox2; and (2) analyzing how posttranslational modifications affecting stem cell pluripotency alter Sox2's DNA binding and bending mechanics. These projects bridge molecular oncology, bacterial pathogenesis, and regenerative medicine through rigorous biochemical analysis.
While specific funding mechanisms aren't detailed, Dr. Malarkey mentors students through hands-on laboratory research within the School of Pharmacy's Team Based Learning framework. His educational philosophy emphasizes questioning theoretical foundations, such as comparing lock-and-key versus induced fit models in protein/ligand binding studies.
The Malarkey Lab operates within Regis University's pharmaceutical sciences infrastructure, employing biochemical and molecular techniques to explore Sox2's dual roles in disease pathogenesis and stem cell regulation through active investigation of protein-molecule interactions and structural dynamics.
