معرفی
Rym Yahia Boudhar is a Researcher at the Unit of Organic Chemistry within the Namur Institute of Structured Matter (NISM) at the University of Namur, serving as Principal Investigator for the active project "Synthesis and antibacterial properties of glycomimetics designed as inhibitors of bacterial Kdo processing enzymes" (2023-2025) under supervisor S. Vincent.
Her research specializes in developing glycomimetic compounds to disrupt bacterial lipopolysaccharide biosynthesis, with a focus on pathogens like Brucella abortus. Key investigations include:
- Design of mannose-based glycomimetics targeting Kdo processing enzymes
- Site-specific incorporation of modified sugars into bacterial LPS structures
- Antibacterial mechanism analysis of enzyme inhibitors
- Synthetic strategies for pathogen-specific glycoconjugates
Her 2025 ACS Chemical Biology publication demonstrates innovative click-chemistry approaches to probe Brucella envelope assembly, reflecting interdisciplinary work bridging organic synthesis, microbial pathogenesis, and therapeutic development. Current efforts prioritize translating glycomimetic designs into novel antibacterial agents against resistant pathogens.
Dr. Boudhar collaborates with an international team including M. Lacritick, A. Reboul, E. Carlier, T. Scaillet, S. Subramanian, J. Wouters, B. Staker, X. De Bolle, and S. Vincent on her funded project, which integrates structural biology, chemical synthesis, and infectiology to develop next-generation antimicrobials through bacterial enzyme targeting.
