معرفی
Stephane Vincent is a Professor at the Unit of Organic Chemistry within the Namur Institute of Structured Matter at the University of Namur. His research bridges bioorganic chemistry with biomedical applications, focusing on enzyme mechanisms, carbohydrate-based drug design, and synthetic methodologies for disease-targeted molecules.
- Education: Doctor of Science (1997) from Université de Strasbourg
His research interests include:
- Design and synthesis of enzyme inhibitors
- Chemical strategies for manipulating lipopolysaccharides
- Development of bioorthogonal labeling techniques
- Applications of calorimetry in drug discovery
- Fluorination methods for PET tracers
- Self-assembled drug delivery systems
Recent research trends involve pathogen targeting through glycosylation and lipopolysaccharide inhibition, with a focus on Acinetobacter baumannii and Brucella abortus. Methodologically, he employs click chemistry, dynamic constitutional frameworks, and radiochemical synthesis for both therapeutic and diagnostic purposes.
Notable projects include:
- MannoClick – Protein functionalization via mannosyltransferase
- STABLE2 – Beta-lactam analogs for carbapenemase detection
- SMART – Automated radiotracer synthesis
- F-Synthesis – Nickel-pincer cofactor enzymology
- ITC-DrugDesign – Calorimetry-driven drug development
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