Casey E. Romanoski

Casey E. Romanoski serves as an Assistant Professor in the Department of Cellular and Molecular Medicine at the University of Arizona, holding concurrent appointments as a BIO5 Fellow, Faculty in the Genetics Graduate Interdisciplinary Program, Member of the Center for Applied Genetics and Genomic Medicine, and Member of the UA Sarver Heart Center.

Her research program investigates the interplay between DNA variation and gene regulation in inflammatory contexts, with primary focus on endothelial cells lining blood vessels and their role in complex diseases like atherosclerosis and hypertension. Utilizing next-generation sequencing integrated with experimental and computational approaches, her laboratory examines how epigenetic modifications, gene expression patterns, and genome-wide association study loci converge to drive disease mechanisms in vascular inflammation.

Recent publications reveal consistent emphasis on respiratory-cardiovascular interactions, particularly how viral infections (e.g., rhinovirus) in asthmatic individuals modulate ACE2 expression and inflammatory pathways relevant to COVID-19 pathogenesis, alongside investigations into CC16-integrin interactions in infection defense.

Her scientific recognition includes the competitive BIO5 Fellowship supporting interdisciplinary translational research.

Dr. Romanoski's collaborative work spans multiple institutional centers focused on genomic medicine translation, with research directly addressing mechanisms of vascular inflammation through integrated molecular approaches.