Bruce Gelb

Bruce Gelb, MD, is a Professor and Director of the Mindich Child Health and Development Institute at the Icahn School of Medicine at Mount Sinai. His research spans multiple institutes including the Cardiovascular Research Institute, Genetics and Genomic Sciences, and Environmental Medicine. Active in clinical and translational genetics, Gelb's work focuses on congenital heart defects and RASopathies.

• Affiliation: Icahn School of Medicine at Mount Sinai
• Leadership: Director, Mindich Child Health and Development Institute
• Institute Memberships: Cardiovascular Research Institute, Black Family Stem Cell Institute, Environmental Medicine, Friedman Brain Institute, Genetics and Genomic Sciences, Graduate School of Biomedical Sciences

Current research examines the genetic basis of congenital heart disease, with recent publications analyzing digenic architectures, aortic root dilation in Phelan-McDermid syndrome, and Fanconi anemia pathogenesis. His work integrates exome sequencing, bioinformatics, and molecular biology to uncover novel disease mechanisms.

Recent publications (2024-2025) highlight collaborations across disciplines including

• Human Genetics (AJHG)
• Clinical Investigation (JCI)
• Bioinformatics (Life Science Alliance)

Key themes: incomplete penetrance, genotype-phenotype correlations, and computational approaches to mutation detection.