معرفی
Binhua P Zhou is a Professor and the Madeline F. James & Edith D. Gardner Endowed Chair in Molecular and Cellular Biochemistry at the University of Kentucky’s College of Medicine. He co-directs the Center For Cancer and Metabolism and co-leads the Molecular and Cellular Oncology Program at the Markey Cancer Center. His research focuses on understanding the molecular mechanisms of cancer metastasis, particularly the role of epithelial-mesenchymal transition (EMT) and transcription factors like Snail/Slug in tumor progression.
Educational Background: Dr. Zhou obtained his MD in Clinical Medicine from Guangzhou Medical University, China, and his PhD in Neuroscience from the University of Texas at Austin. He completed a postdoctoral fellowship in breast cancer research at the University of Texas MD Anderson Cancer Center.
Research Interests: His work investigates how signaling pathways regulate EMT, metastasis, and cancer metabolism. Key areas include the functional roles of Snail/Slug transcription factors, NF-κB signaling, and metabolic reprogramming in breast and lung cancers. He explores translational opportunities for therapeutic targets to inhibit metastasis.
Publications Overview: His research spans over 20 years, with seminal contributions on Snail regulation, EMT, and the interplay between inflammation and metastasis. Notable studies include defining Snail’s phosphorylation by GSK-3β, the role of BRD4 in EMT-driven cancers, and the metabolic vulnerabilities of basal-like breast cancer.
Awards & Recognition: While specific honors aren’t listed, his leadership roles and high-impact publications reflect significant recognition in cancer research.
Advising & Grants: His roles in major cancer centers imply extensive grant support and mentorship of researchers in cancer biology and metastasis.
Labs & Teams: He leads a multidisciplinary team in the Markey Cancer Center and collaborates with institutions globally to advance metastasis research and therapeutic development.
