معرفی
Bhushan Nagar is a Professor in the Department of Biochemistry at McGill University, leading the Nagar Lab within the Centre de Recherche en Biologie Structurale (CRBS). His research focuses on the structural biology of signal transduction in the innate immune system and lysosomal proteins, using X-ray crystallography, Cryo-EM, and biophysical techniques.
Key research areas:
- Structural analysis of Toll-like receptors (TLRs) and IRAK family proteins
- Molecular mechanisms of IFIT proteins in viral RNA recognition
- RNA-binding proteins like Argonaute2 and DAP5
- Lysosomal enzyme structures (e.g., acid ceramidase, mannosidase)
- Drug discovery targeting eIF4A and DEAD-box helicases
Recent publication trends (2018-2023) highlight structural insights into
- innate immune sensors (IFIT1, NEU1)
- lysosomal pathways (GlcNAc-1-phosphotransferase, saposin D)
- translational control (eIF4A, mTORC1/S6K axis)
- deubiquitinase activity (MYSM1 in hematopoiesis)
- allosteric enzyme inhibition (caspase-6, acid ceramidase)
Laboratory members:
- Current: Zixian Li, Garvit Bhatt, Danilo Ide, Alexei Gorelik
- Alumni: Filipp Frank, Jason Liang, Heidi Olesen, Genevieve Virgili, and others
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