معرفی
Professor Arthur Kaser is a leading academic gastroenterologist and Professor of Gastroenterology at the University of Cambridge. He leads the Gastrointestinal Diseases theme of the NIHR Cambridge Biomedical Research Centre, a partnership between Cambridge University Hospitals and the University of Cambridge.
- Department of Medicine
- Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID)
- British Society for Immunology Funding Recipient
His groundbreaking research focuses on the mechanisms of Inflammatory Bowel Disease (IBD), including:
- Dysregulation of enterocyte cell intrinsic processes causing IBD
- Genetic polymorphisms linked to disease risk
- Purine nucleoside metabolism and unfolded protein response
- Mitochondrial metabolism in immune regulation
- Role of GPR35 and ORMDL proteins in epithelial homeostasis
Recent publications highlight his work across genetic models, metabolic pathways, and clinical trials in IBD, with a focus on:
- AAV8 gene therapy for mitochondrial disorders
- ER stress and autophagy in intestinal epithelium
- Anti-IL-23 therapies (mirikizumab, risankizumab)
- Polyunsaturated fatty acids in Crohn's disease pathogenesis
Scientific honors include:
- Fellow of the Academy of Medical Sciences (FMedSci)
- Fellow of the Royal Society (FRS)
He collaborates with clinicians and researchers including Dr. James Lee, Dr. Nicole Kaneider, Dr. Trevor Lawley, and Professor Gordon Dougan. His work is supported by the Medical Research Council and institutional grants from the NIHR Cambridge Biomedical Research Centre.
