James Nathan

Professor James Nathan is affiliated with the University of Cambridge through the Cambridge Institute for Therapeutic Immunology & Infectious Disease (CITIID) and Cambridge Stem Cell Institute. His research focuses on cellular oxygen/nutrient sensing mechanisms, particularly their role in epigenetic regulation, transcriptional pathways, and disease progression.

• Key Research Areas:
  • Oxygen-sensitive enzymes (HIF pathway, PHDs, TETs)
  • Chromatin modifications by metabolite availability
  • Metabolic regulation of immunity and cancer
  • Mitochondrial metabolism in hypoxia responses
  • Epigenetic control of gene expression
• Scientific Awards:
  • Wellcome Trust Senior Clinical Fellow
• Technologies:
  • Genome-wide mutagenesis screens
  • Metabolic assays
  • CRISPR-Cas9 functional genomics
  • Single-cell analysis platforms

His work has direct implications for inflammatory diseases, cancer therapeutics, and regenerative medicine, combining biochemical, genetic, and clinical approaches to bridge fundamental biology with translational applications.