معرفی
Dr. Anil Akturk is an Associate Research Scientist at The Jackson Laboratory (Bar Harbor, ME) affiliated with the Tarchini Lab. His research focuses on dissecting the roles of G-protein signaling pathways in inner ear development, particularly the molecular mechanisms governing hair bundle morphogenesis in auditory hair cells.
He investigates how proteins like GPSM2 and GNAI regulate stereocilia elongation and row identity differentiation, using genetic models, organotypic cultures, and biochemical approaches. His work bridges developmental biology and sensory physiology, with implications for understanding hearing loss mechanisms.
Key research findings include defining the GPSM2-GNAI complex's role in stabilizing MYO15A-EPS8 complexes at stereocilia tips, critical for forming the staircase-like structure of hair bundles. His lab employs mouse models to study auditory epithelium development and employs advanced microscopy techniques for structural analysis.
Funded by NIH grants (e.g., R01 DC015242), his work has been published in journals like Current Biology and Proceedings of the National Academy of Sciences. Collaborations involve structural biology and genetic screening efforts to identify novel pathway components.
