معرفی
Angus Nairn is the Charles B.G. Murphy Professor of Psychiatry at Yale School of Medicine, with a secondary appointment in Pharmacology. He co-directs the Yale/NIDA Neuroproteomics Center and holds affiliations with the Alzheimer's Disease Research Center and Interdepartmental Neuroscience Program.
- Education: PhD in Muscle Biochemistry (University of Birmingham, 1979); Postdoctoral in Molecular Neuroscience (Yale University)
His research focuses on dopamine-regulated signal transduction in striatal neurons, particularly through phosphoproteins like DARPP-32, RCS, and ARPP-16. He investigates their roles in schizophrenia, addiction, and neurodegenerative diseases using biochemical, molecular, and mouse knockout models.
Recent publications highlight his work on subcellular proteomics in Alzheimer’s disease, multi-omic PTSD studies, and computational methods for analyzing neuroproteomic data. Collaborations with TuKiet Lam and Marina Picciotto emphasize translational approaches to neurodegeneration and addiction.
His lab develops techniques for single-cell proteomics and CSF biomarker discovery, including projects on tau hyperphosphorylation and mitochondrial metabolism. No formal awards or student advisement details were explicitly stated.