TuKiet Lam

TuKiet Lam is a Research Scientist and Director of the Keck MS & Proteomics Resource at Yale School of Medicine's Department of Molecular Biophysics and Biochemistry. He holds joint leadership of the Discovery Proteomics Core of the Yale/NIDA Neuroproteomics Center and is affiliated with Yale Cancer Center's Cancer Signaling Networks Program.

Dr. Lam's research focuses on advanced mass spectrometry applications in proteomics and metabolomics. Key areas include:

• Protein identification and quantitative profiling in complex biological systems
• Analysis of posttranslational modifications (phosphorylation, ubiquitination, palmitoylation)
• Biomarker discovery for neurological disorders and cancers
• Development of novel mass spectrometry workflows

His work spans diverse samples including brain tissue, cerebrospinal fluid, extracellular vesicles, and clinical specimens.

Recent publications demonstrate strong research output in neurodegeneration (Alzheimer's, Parkinson's), oncology (glioblastoma), and substance use disorders. Common themes include subcellular proteomics, extracellular vesicle characterization, and multi-omic approaches integrating proteomic data with transcriptomic and clinical findings.

Dr. Lam leads the Keck MS & Proteomics Resource, which provides:

• High-resolution tandem mass spectrometry services
• Protein identification and quantification
• Posttranslational modification analysis
• Targeted metabolomics

The facility supports numerous NIH-funded projects and is equipped with Orbitrap mass spectrometers maintained through NIH S10 grants.