Andrew Angel

Dr. Andrew Angel is a Senior Lecturer in the School of Natural and Computing Sciences at the University of Aberdeen, where he conducts interdisciplinary research at the interface of physics, mathematics, and molecular biology. He is actively involved in teaching and research, currently accepting PhD students in Physics.

His primary research interests include:

• Mathematical and stochastic modeling of biological systems
• Gene expression and transcription dynamics
• Chromatin and nucleosome organization
• Epigenetic regulation, particularly in vernalization
• Metabolic cycling and its impact on transcription
• Quantitative analysis of ChIP-seq data

Dr. Angel applies techniques from statistical physics and computational modeling to understand complex biological phenomena. His work spans from fundamental physical models to detailed molecular mechanisms in gene regulation.

The recent publications highlight a strong focus on transcriptional regulation, chromatin dynamics, and epigenetic memory. The research combines experimental collaborations with sophisticated modeling approaches, particularly in understanding how RNA polymerase navigates nucleosomal barriers, how chromatin signatures regulate transcription, and how metabolic states influence gene expression. Several studies involve yeast and human systems, employing cutting-edge techniques like 4sU sequencing for transcriptome mapping.

Dr. Angel has collaborated extensively with leading researchers including Professor Jane Mellor (University of Oxford), Professor Francois Robert (IRCM Montreal), and Dr. Michael Tellier (University of Leicester), reflecting his integrated approach to biological questions.

His scientific contributions are evident through publications in high-impact journals such as Nature, Molecular Cell, Cell Reports, and PNAS. While no specific awards are listed, the quality and impact of his publications indicate significant recognition in the fields of epigenetics, transcription, and biophysical modeling.

Dr. Angel advises students in Physics and related interdisciplinary areas, contributing to the training of next-generation scientists in quantitative biology. His research is supported by collaborative networks and institutional resources at the University of Aberdeen.

He is affiliated with the following research groups and collaborations:

• Transcription, Chromatin and the Yeast Metabolic Cycle (with Prof. Jane Mellor)
• Transcription through nucleosomes (with Prof. Francois Robert)
• Analysis of ChIP-seq data (with Dr. Michael Tellier)