Michael F. Carey

Michael F. Carey is a Professor in the Department of Biological Chemistry at the David Geffen School of Medicine, University of California Los Angeles. His research focuses on the fundamental mechanisms of eukaryotic gene regulation, particularly examining the interplay between chromatin structure and transcription machinery.

Dr. Carey's research interests center on chromatin biology and transcription mechanisms, with specific expertise in nucleosome dynamics, RNA polymerase II function, and epigenetic regulation. His laboratory investigates how chromatin structure influences transcription initiation and elongation, with particular focus on the roles of chromatin remodeling complexes such as INO80 and SWI/SNF in regulating gene expression. His work spans from basic biochemical mechanisms to implications in cellular processes including stem cell maintenance, neuronal differentiation, and aging.

Analysis of Dr. Carey's recent publications reveals a strong emphasis on chromatin architecture and transcription regulation. His research demonstrates how chromatin remodeling complexes maintain genomic stability, regulate enhancer-promoter communication, and control cell-type specific gene expression programs. His work bridges structural biochemistry with functional genomics, providing mechanistic insights into how transcription machinery interacts with nucleosomal templates.

Dr. Carey has been consistently funded by NIH grants including the IRACDA program (K12GM106996), and multiple R01 grants focusing on chromatin and transcription mechanisms. His laboratory has made significant contributions to understanding the molecular mechanisms of transcriptional activation, nucleosome remodeling, and the coordination between chromatin structure and gene expression.

His laboratory has developed numerous biochemical and molecular techniques for studying transcription and chromatin, with several methodological papers published in Cold Spring Harbor Protocols. Dr. Carey has also mentored numerous graduate students and postdoctoral fellows who have gone on to establish successful careers in academia and industry.