Andrew Sharrocks

Andrew Sharrocks is Professor of Molecular Biology at the University of Manchester's Division of Molecular & Cellular Function. His research focuses on transcriptional control mechanisms, chromatin dynamics, and their roles in cancer and stem cell differentiation. He leads a team investigating signal-mediated gene regulation, epigenetic networks in oesophageal adenocarcinoma, and transcriptional drivers of cellular differentiation.

Research Interests: His lab employs systems biology approaches including RNA-seq, ChIP-seq and CRISPR-Cas9 to study:

• ERK pathway signaling in chromatin remodeling
• Transcription factor networks in oesophageal cancer progression
• Enhancer formation during stem cell differentiation

Recent Publications demonstrate focus on epigenomic alterations in disease models (Kabuki syndrome, liver fibrosis) and molecular adaptations in gastrointestinal cancers, utilizing multi-omics methodologies.

Team & Training: Currently supervises 2 PhD students and 3 postdoctoral researchers. Has trained 23 PhD students (3 now leading independent groups) and 21 postdocs (4 now group leaders).