Alexandre Gaspar Maia

Dr. Alexandre Gaspar Maia is an Associate Professor in the Department of Laboratory Medicine and Pathology at Mayo Clinic, Rochester, Minnesota. He leads the Functional Epigenomics Laboratory within the Center for Individualized Medicine, focusing on epigenomic profiling and cancer stem cell research. His academic roles include serving as Associate Director of the Epigenomics Program and holding appointments in Pharmacology.

Education:

• Ph.D. in Molecular Biology, University of Coimbra (2010)
• Postdoctoral Fellowship in Chromatin Biology, Icahn School of Medicine at Mount Sinai (2016)
• Bachelor of Science in Aquatic Sciences, University of Porto (2002)

Research Interests: Epigenomics, cancer stem cells, tumor heterogeneity, ovarian cancer, single-cell sequencing technologies (RNA-seq, ATAC-seq), CRISPR/Cas9-based mechanisms, and microfluidic organoid cultures. His work integrates advanced sequencing and bioinformatics to target transcriptional dependencies in cancer.

Professional Highlights:

• Recipient of multiple awards, including the Career Enhancement Program Award (Breast SPORE, 2022–2024) and DoD Ovarian Cancer Academy Junior Investigator (2021–2025).
• Developed novel methodologies for single-cell multi-omics analysis and functional validation of epigenetic regulators.

Lab & Collaborations: Directs the Functional Epigenomics Lab, collaborating on projects involving tumor heterogeneity, personalized medicine, and regenerative sciences curriculum development. Active in initiatives like the Mayo Clinic Comprehensive Cancer Center and Molecular Pharmacology research programs.