Alexey Petrov

Alexey Petrov is an Associate Professor in the Department of Biological Sciences at Auburn University, affiliated with the College of Sciences and Mathematics. His research focuses on the molecular mechanisms of protein synthesis, particularly ribosome dynamics and translational regulation.

His research interests lie at the intersection of biochemistry, biophysics, and molecular biology. He investigates how ribosomes achieve high-speed and high-fidelity protein synthesis, how mRNA structure and modifications regulate translation, and how viral elements hijack the translational machinery. His lab employs cutting-edge single-molecule fluorescence techniques and biochemical assays to dissect these processes in real time.

The recent publications highlight a strong focus on ribosome translocation, initiation, elongation fidelity, and the impact of mRNA modifications such as 2′-O-methylation and m6A on translation dynamics. His work frequently involves the study of viral internal ribosome entry sites (IRES), providing insights into alternative translation mechanisms. The research is characterized by a deep mechanistic and kinetic understanding of translation, often revealing multiple parallel pathways and dynamic conformational changes.

Alexey Petrov received his B.S. from Moscow State University, Russia, followed by a Ph.D. from the University of Maryland, College Park, under Dr. Jonathan Dinman. He completed his postdoctoral training with Dr. Joseph D. Puglisi at Stanford University, where he pioneered single-molecule studies of translation.

• Postdoctoral fellow with Dr. Joseph D. Puglisi, Stanford University
• Ph.D. with Dr. Jonathan Dinman, University of Maryland, College Park
• B.S., Moscow State University, Russia

He leads an active research group within Auburn University's Biophysics Cluster, established in 2017. His lab is dedicated to advancing the single-molecule toolbox by developing new instrumentation and data analysis pipelines to make these powerful techniques more accessible. While specific grants are not listed, his publication record in top journals suggests a well-funded and productive research program. He mentors students and postdoctoral researchers in biochemical and biophysical methods, contributing to the training of the next generation of scientists.