جستجوی استاد راهنمای دانشگاهی

• Data Science
• Machine Learning
• Computational Harmonic Analysis
• +۶ مورد دیگر

Pierre Vandergheynst is a Full Professor at the Swiss Federal Institute of Technology Lausanne (EPFL) in the Department of Electrical Engineering, with a courtesy appointment in Computer and Communication Sciences. He serves as EPFL’s Vice-Provost for Education since 2015 and leads the Signal Processing Laboratory 2 (LTS2). His research spans harmonic analysis, sparse approximations, mathematical data processing, and applications in signal/image processing, computer vision, machine learning, and graph-based data analysis. PhD in Mathematical Physics (1998), Université catholique de Louvain Postdoctoral Researcher at EPFL (1998-2001) Assistant Professor at EPFL (2002-2007) His research explores geometry/symmetry in high-dimensional data, redundant dictionaries for dimensionality reduction, and computational harmonic analysis on manifolds. Recent work focuses on protein structure modeling, geometric deep learning, and graph-based signal processing. Key article trends include graph neural networks for protein analysis, geometric deep learning in neuroscience, and structured knowledge priors in neural models. His 2023-2025 publications emphasize interpretable AI, long-range dependencies in graphs, and molecular representation learning. Scientific Awards: IEEE Signal Processing Magazine Best Paper Award (2023) Signal Processing Society Best Paper Award (2022) Apple ARTS Award (2007) De Boelpaepe Prize, Royal Academy of Sciences of Belgium (2009-2010) He has supervised over 30 PhD theses and contributed to foundational work in graph signal processing, compressive sensing, and geometric deep learning. His lab develops tools for data science on non-Euclidean structures, with applications in medicine, astronomy, and wireless systems.

Olga Dontsovaمشاهده پروفایل

استاد

• Molecular Biology
• Bioorganic Chemistry
• Ribonucleoprotein Complexes
• +۳ مورد دیگر

Olga Dontsova is a Full Professor at Moscow State University (MSU) in the Faculty of Chemistry. She serves as Head of the Division of RNA Structure and Function at the Belozersky Institute of Physico-Chemical Biology and Head of the Chair of Chemistry of Natural Compounds. Her research spans molecular biology, bioorganic chemistry, and RNA-based mechanisms. Research Focus: She investigates structure-functional relationships in ribonucleoprotein complexes, with emphasis on translation machinery, transfer-messenger RNA (tmRNA) interactions with ribosomes, RNA methyltransferases, and telomerase's role in cancer. Her team pioneered a chemical-biochemical-genetic approach to map mRNA topography in ribosomes, elucidate trans-translation dynamics, and characterize novel RNA-modifying enzymes. Scientific Contributions: Developed a molecular dynamic model for trans-translation Discovered unique yeast telomerase with unconventional properties Investigated functional roles of modified RNA residues in translation Honors: Member of Academia Europaea (2014) Corresponding Member of Russian Academy of Sciences (2006) European Academy Award for Young Scientists (1994) Grants & Leadership: Her work has been funded by HHMI, HFSP, CRDF, INTAS, RFFI, and Russian Ministry of Science and Education. She chairs the Biology Panel of the Russian Scientific Foundation and serves on editorial boards for Biochimie, Russian Journal of Molecular Biology, and Acta Naturae. Teaching: As a supervisor of 21 Ph.D. students and numerous diploma projects, she teaches advanced courses at MSU while maintaining an active research program.

Steven G. Clarkeمشاهده پروفایل

استاد

• Biochemistry
• Systems Biology
• Biological Regulation
• +۸ مورد دیگر

Dr. Steven G. Clarke is a Distinguished Professor at UCLA Department of Chemistry & Biochemistry and director of research at the Molecular Biology Institute . His work bridges protein chemistry , methylation biology , and aging research through studies of spontaneous protein damage and its repair mechanisms. Education: BA in Chemistry and Zoology, Pomona College (magna cum laude, Phi Beta Kappa) PhD in Biochemistry and Molecular Biology, Harvard University (NSF Fellow) Postdoctoral Fellowship at UC Berkeley (Miller Fellow) Dr. Clarke's research focuses on protein isoaspartyl repair via PCMT1/PIMT enzymes , ribosomal protein methylation in Saccharomyces cerevisiae , and PRMT family characterization including PRMT7 and PRMT9. His lab combines biochemical assays , genetic models , and structural analysis to investigate aging mechanisms and disease implications. Recent publications highlight: COQ5 structure-function analysis in coenzyme Q biosynthesis PCMTD1 ubiquitin ligase interactions PRMT7 substrate specificity in histone H2B Protein isoaspartyl impacts on T cell function in lupus Novel PRMT inhibitors for cancer therapy Methionine addiction in osteosarcoma malignancy Major scientific awards: American Chemical Society Ralph F. Hirschmann Award in Peptide Chemistry NIH MERIT Award Ellison Medical Foundation Senior Scholar Award William C. Rose Award, ASBMB UCLA Distinguished Teaching Award (Eby Award winner) Current lab members include PhD candidates Eric Pang (UCSB) and Sining "Cindy" Wang (UCLA), while undergraduates Celeste Medina-Seymoure , Elizabeth Oroudjeva , Olivia Pacheco , and Jasmine Winter contribute to ongoing proteostasis studies. Collaborations with Profs. Jose Rodriguez and Catherine Clarke demonstrate interdisciplinary research approaches.

Zhe Jiمشاهده پروفایل

استادیار

• Data Science
• Computational Biology
• Functional Genomics
• +۴ مورد دیگر

Zhe Ji is an Assistant Professor in the Department of Biomedical Engineering at McCormick School of Engineering and the Department of Pharmacology at Feinberg School of Medicine, Northwestern University. His research integrates computational and experimental genomics to study gene transcription and RNA translation in cell fate commitment and oncogenic processes, aiming to develop precision medicine strategies. **Education**: Postdoctoral Fellow in Cancer Systems Biology, Harvard Medical School Postdoctoral Fellow in Computational Biology, Broad Institute of MIT and Harvard Ph.D. in Computational Genomics, Rutgers University B.S. in Biotechnology, Nanjing University, China **Research Focus**: Keywords include Data Science, Computational Biology, Functional Genomics, RNA, Cancer, Inflammation, and Machine Learning. The lab explores regulatory mechanisms underlying disease, with a focus on translational control, cancer metastasis, and inflammatory networks. **Grants & Advising**: No specific grants or student advisees listed. The lab emphasizes collaborative projects and computational-experimental approaches. **Lab Affiliations**: Zhe Ji’s lab is part of Northwestern’s interdisciplinary environment, bridging engineering and medicine to advance genomic technologies and therapeutic strategies.

Amy E. Fraleyمشاهده پروفایل

استادیار

• Natural Products Biosynthesis
• Biotechnology
• Biochemistry
• +۶ مورد دیگر

Amy E. Fraley is an Assistant Professor at ETH Zürich, Department of Chemistry and Applied Biosciences, and leads the Medicinal Chemistry Research Group. Her cross-disciplinary work bridges natural products biosynthesis, pharmaceutical sciences, and environmental sustainability through enzymatic chemistry and biotechnology. BSc in Chemistry, Millersville University of Pennsylvania (2014) PhD in Medicinal Chemistry, University of Michigan College of Pharmacy (2019) Postdoctoral work at ETH Zürich Institute of Microbiology under Prof. Jörn Piel Her research focuses on harnessing biosynthetic enzymes (e.g., halogenases, monooxygenases, Diels-Alderases) to create sustainable bioactive metabolites. She explores natural product biosynthesis in fungi and marine bacteria, targeting disease mechanisms and green chemistry applications. Recent work includes metagenomic studies of Lake Chilika microbial mats and polyketide synthase engineering. Notable scientific awards include the 2024 JSP Fellow at Bürgenstock Conference, 2018 Rackham Predoctoral Fellowship, and multiple University of Michigan honors. Her group secured funding from the ETH4D Doctoral Mentorship Grant and Messerli Foundation . Collaborations span structural biology, synthetic chemistry, and microbiology, with key contributions to flavoenzyme characterization and bioactive compound libraries . The lab emphasizes interdisciplinary training and innovation in biocatalytic tools for organic synthesis.

John A. Copland, IIIمشاهده پروفایل

استاد

• Cancer Biology
• Molecular Carcinogenesis
• Translational Research
• +۳ مورد دیگر

Dr. John A. Copland III is a Professor of Cancer Biology and Biochemistry & Molecular Biology at Mayo Clinic in Jacksonville, Florida. He leads the Cancer Biology and Translational Research Laboratory, focusing on molecular mechanisms of carcinogenesis, tumor progression, and development of targeted cancer therapies. Education: PhD in Physiology & Endocrinology (Medical College of Georgia), MS in Endocrinology (Medical College of Georgia), BS in Chemistry (Columbus College), with postdoctoral training at University of Texas Medical Branch. Research interests center on: Identifying tumor suppressor genes (e.g., RhoB, TBR3, GATA3) and oncogenes (e.g., FOXO3a, SCD1, NPTX2). Developing patient-derived xenografts and live cell models for personalized medicine. Designing SCD1 inhibitors via in silico modeling for clinical trials. Recent publications highlight his work on SCD1 inhibition in leukemia and thyroid cancer ImmunoPET imaging of thyroid tumors CRISPR-identified drug synergies in cholangiocarcinoma Patient-specific combination therapies using xenograft models

James C. Gumbartمشاهده پروفایل

استاد مدعو

• Computational Biochemistry and Biophysics
• Membrane proteins
• Free-energy calculations
• +۷ مورد دیگر

James C. Gumbart is an Adjunct Professor in the School of Physics at Georgia Institute of Technology, with additional affiliation to the School of Chemistry and the Institute for Bioengineering and Bioscience . His research leverages molecular dynamics simulations to decode the atomic-level mechanisms of bacterial proteins and cellular structures. B.S., Physics and Mathematics, Western Illinois University, 2003 Ph.D., Physics, University of Illinois at Urbana Champaign, 2009 Dr. Gumbart's work bridges computational biophysics and biochemistry to understand: Mechanisms of bacterial membrane protein insertion and nutrient import Structural dynamics of cell wall mechanics SARS-CoV-2 spike protein interactions with ACE2 Free-energy calculations for protein-ligand binding Applications of machine learning in biomolecular simulations His publications reflect trends in membrane protein biophysics , viral dynamics , and computational drug design , with a strong emphasis on interdisciplinary techniques. Awards include multiple fellowships and grants from NSF , DOE , and NIAID . He has mentored numerous PhD students, including Zijian Zhang , David Ryoo , and Andrew Pang , whose work has advanced understanding of bacterial systems and viral proteins. The Gumbart Lab integrates high-powered supercomputing and advanced software to model biomolecular processes, fostering collaborations with institutions like the National Institutes of Health and Argonne National Laboratory .

Kathrin Langمشاهده پروفایل

استاد

• Chemical Biology
• Protein Engineering
• Genetic Code Expansion
• +۳ مورد دیگر

Kathrin Lang is a Full Professor at the Department of Chemistry and Applied Biosciences, ETH Zurich, and Head of the Organic Chemistry Laboratory. Her research focuses on chemical biology, particularly the development of tools for genetic code expansion to incorporate non-canonical amino acids into proteins and advance bioorthogonal chemistries for studying biological processes. Keywords: Genetic Code Expansion, Bioorthogonal Chemistry, Protein Engineering, Ubiquitylation Networks, Post-Translational Modifications. Lang’s work emphasizes proximity-triggered crosslinking reactions, bioorthogonal labeling, and in vivo chemistries to address challenges in protein interaction mapping and structural elucidation. Her group’s recent publications highlight methodologies for dual protein labeling, deciphering ubiquitin code, and enhancing cycloaddition reactivity. Current projects include exploring cyclopropene-fused dibenzocyclooctynes for improved labeling and investigating methylated lysine as a conformational regulator in Hsp90. Funding sources include the ERC (Ubl-tool), DFG (SFB1035, SPP1926), and ETH Zurich. She contributes to education through courses like Genetic Code Expansion for Studying Posttranslational Modifications and Chemical Biology and Synthetic Biochemistry . Collaborative efforts span structural biology, microbiology, and synthetic biochemistry, with applications in ubiquitin research and cellular imaging.

Megan Bergkesselمشاهده پروفایل

استاد پژوهش

• Molecular Microbiology
• Antimicrobial Resistance
• Bacterial Physiology
• +۳ مورد دیگر

Dr. Megan Bergkessel is a Research Professor in Molecular Microbiology at the University of Dundee's School of Life Sciences. Her research focuses on understanding how bacteria like Pseudomonas aeruginosa regulate activities during growth arrest, particularly in resource-limited environments. This work addresses antibiotic tolerance mechanisms critical to chronic infections. Principal Investigator leading studies on non-growing bacterial physiology Recipient of a £900k UKRI Future Leaders Fellowship (2020) Expertise in antimicrobial resistance and microbial stress responses Current research explores regulatory pathways enabling protein synthesis in non-growing states, with implications for developing novel infection treatments. Supervises PhD projects investigating two-component signaling systems and environmental sensing in P. aeruginosa. Recognized for teaching excellence in Biological and Biomedical Sciences programs. PhD opportunities: Adaptive antimicrobial resistance mechanisms and environmental sensing roles Media commentary available via Corporate Communications

Matthew Kimberمشاهده پروفایل

استاد

• Structural Biology
• Bacterial Systems
• Biochemistry
• +۳ مورد دیگر

Dr. Matthew Kimber is a Professor in the Department of Molecular and Cellular Biology at the University of Guelph. His research focuses on structural biology of bacterial systems, particularly bacterial polysaccharides and microcompartments. He employs x-ray crystallography to study molecular architectures, with current projects exploring mechanisms of bacterial surface polysaccharide assembly and bacterial microcompartment function. Education: B.Sc. (Hons) Molecular Genetics and Molecular Cell Biology from the University of Toronto (1993), Ph.D. in Molecular and Medical Genetics from the University of Toronto (2000). Research Interests: Structural basis of polysaccharide assembly and modification, bacterial microcompartment structure-function relationships, and enzyme mechanisms. Key projects include studies on glycosyltransferases, carboxysomes, and aminoacetone degradation pathways. Lab Members: Current graduate students include Laura Seidel, Liam Noseworthy, Manitabhai Govind, and Shaoqian Zong. Former members include Patrick Ryan, Evan Mallette, and Tom Keeling. Lab Focus: Probing structural details of biological molecules to understand function, with emphasis on bacteria’s strategies for polysaccharide modification and microcompartment assembly. Recent work includes characterization of enzymes involved in O-antigen biosynthesis and microcompartment shell proteins.

Clifford P. Brangwynneمشاهده پروفایل

استاد

• Biophysics
• Bioengineering
• Soft Matter Physics
• +۳ مورد دیگر

Clifford P. Brangwynne is the June K. Wu '92 Professor of Chemical and Biological Engineering and Bioengineering at Princeton University, serving as Director of the Omenn-Darling Bioengineering Institute. His research bridges biophysics, bioengineering, and cell biology to investigate the physical principles governing intracellular organization through liquid-liquid phase separation. Education Ph.D. in Applied Physics, Harvard University (2007) B.S. in Materials Science and Engineering (minor in Physics), Carnegie Mellon University (2001) Research Focus Brangwynne's lab pioneers the study of membrane-less organelles (biomolecular condensates) formed via phase separation, exploring their roles in nuclear architecture, genome regulation, and disease mechanisms. His work integrates soft matter physics with advanced cell biology to uncover how these condensates form, function, and contribute to pathological protein aggregation in neurodegenerative disorders, while developing synthetic organelle engineering for biomedical applications. Publication Trends His publications consistently demonstrate how liquid phase condensation governs cellular organization across scales—from nuclear genome restructuring to pathological aggregation. The interdisciplinary approach reveals fundamental physical principles while driving technological innovations in organelle engineering and disease modeling. Major Awards Breakthrough Prize for Life Sciences (2023) Raymond and Beverly Sackler International Prize in Biophysics (2023) Tsuneko & Reiji Okazaki Award (2021) Wiley Prize in Biomedical Sciences (2020) Blavatnik National Award in Life Sciences (2020) Human Frontier Science Program Nakasone Award (2020) Michael and Kate Bárány Award, Biophysical Society (2020) HHMI Transformative Technology Award (2019) MacArthur Fellow (2018) HHMI, Simons Foundation, and Bill & Melinda Gates Foundation Faculty Scholar (2016) SCB Gibco Emerging Leader Prize, American Society of Cell Biology (2015) Sloan Research Fellowship (2014) NSF CAREER Award (2013) NIH New Innovator Award (2012) Searle Scholar Award (2012) Helen Hay Whitney Fellow (2008-2010) Advising and Funding He mentors graduate students including Jordy Botello, Yi-Che (Eje) Chang, Yoonji Kim, Claire Weaver, Lennard Wiesner, and Jessica Zhao. Research is supported by HHMI, Simons Foundation, Bill & Melinda Gates Foundation, NIH, NSF, and the Human Frontier Science Program. Laboratory and Collaborations Leading the Soft Living Matter Group, Brangwynne collaborates with theorists including Mikko Haataja (Princeton Mechanical Engineering), Ned Wingreen (Princeton Molecular Biology), and Rohit Pappu (WUSTL), while contributing to the NIH 4D Nucleome Consortium to advance understanding of nuclear organization.

• Skeletal Muscle Growth
• Ribosome Biogenesis
• Exercise Physiology
• +۴ مورد دیگر

Gustavo Nader, Ph.D., is a Professor of Kinesiology at The Pennsylvania State University's College of Health and Human Development, where he holds the Dorothy Foehr Huck and J. Loyd Huck Endowed Chair in Molecular, Cellular and Integrative Physiology. His research laboratory at 101 Noll Lab focuses on molecular mechanisms of skeletal muscle adaptation, employing human, animal, and cellular models to investigate ribosome biogenesis, transcriptional regulation, and muscle growth control in contexts ranging from exercise hypertrophy to cancer cachexia. Dr. Nader's research examines fundamental processes including: Ribosome biogenesis and its role in muscle growth regulation Epigenetic control of RNA Polymerase I activity Molecular pathways in mechanical overload-induced hypertrophy Tumor-induced muscle wasting mechanisms Biomimicry approaches inspired by hibernator physiology His work spans exercise physiology, cancer biology, and environmental stress responses. Analysis of his 15 most recent publications (2015-2025) reveals predominant themes in muscle hypertrophy mechanisms, cancer cachexia pathophysiology, ribosomal function analysis, and environmental stress impacts on muscle. His work consistently integrates molecular techniques with physiological models across species. Notable scientific recognitions include: Dorothy Foehr Huck and J. Loyd Huck Chair appointment (2024) Huck Institutes Leadership Fellowship (2025-2026) Dr. Nader leads an active research team investigating muscle plasticity, with current projects funded through the Huck Institutes of the Life Sciences. He collaborates extensively through Penn State's Integrative and Biomedical Physiology graduate program and Center for Cellular Dynamics.

Gustavo M. Silvaمشاهده پروفایل

دانشیار

• Molecular Biology
• Cell Biology
• Ubiquitin Signaling
• +۴ مورد دیگر

Gustavo M. Silva is the Jack H. Neely Associate Professor of Biology at Duke University's Trinity College of Arts & Sciences, a position he has held since 2025. Previously, he served as Associate Professor of Biology (2024-present) and Assistant Professor of Cell Biology (2022-present) at Duke. His research is conducted through the Silva Lab (sites.duke.edu/silvalab), which focuses on molecular mechanisms of cellular stress response. Education: Ph.D. from University of Sao Paulo (Brazil), 2010 B.Sc. from University of Sao Paulo (Brazil), 2004 Dr. Silva's research centers on understanding how gene expression is regulated at transcriptional and translational levels during cellular stress. His lab specifically investigates how the ubiquitin system controls protein synthesis and degradation dynamics under stress conditions, which are critical for cellular physiology. His work has significant implications for understanding disease mechanisms where protein homeostasis is disrupted. The research combines biochemical, genetic, and proteomic approaches to dissect these complex regulatory networks. His publication record demonstrates a clear evolution from fundamental studies on redox regulation and proteasome function to more complex investigations of ubiquitin signaling in translation control and stress response. Recent work increasingly focuses on K63-linked ubiquitination's role in ribosome function and translation regulation, with growing emphasis on the clinical implications of these mechanisms in disease contexts including cancer. Scientific Awards & Recognition: Paul T. Englund Emerging Scholar Award (Johns Hopkins School of Medicine, 2024) Dean's Award for Excellence in Mentoring (Duke Graduate School, 2023) Science Diversity Leadership Award (Chan Zuckerberg Initiative, 2022) Best Professor Award (Vanderbilt Basic Sciences Juneteenth Committee, 2022) 100 inspiring Black scientists in America (CellPress, 2020) Dr. Silva actively mentors students at multiple levels, as evidenced by his Dean's Award for Excellence in Mentoring. His research is supported by substantial funding including NIH grants such as the Tri-Institutional Molecular Mycology and Pathogenesis Training Program (2024-2029) and 'Stalling cancer at the ribosome' from the V Foundation for Cancer Research (2025-2028). He also serves as Principal Investigator on multiple R01 grants focused on ubiquitin's role in translation control and stress response. The Silva Lab maintains strong collaborative relationships with institutions including the Chan Zuckerberg Initiative and ETH Zurich, and participates in several interdisciplinary training programs at Duke that support underrepresented students in biomedical sciences.

• Precision Medicine
• Cancer Biology
• Drug Discovery
• +۵ مورد دیگر

Brinton Seashore-Ludlow is an Associate Professor at the Department of Oncology-Pathology, Karolinska Institute (KI), where he serves as team leader in Olli Kallioniemi's research group and group leader of the biology team at Chemical Biology Consortium Sweden (CBCS), SciLifeLab's national infrastructure. PhD in Biochemistry, KTH Royal Institute of Technology (2012) MSc in Chemical Biology, California Institute of Technology (2007) BA in Biochemistry, Macalester College (2001) His research bridges precision medicine and cancer biology through: Developing ex vivo patient-derived models for drug response prediction Molecular determinants of therapeutic efficacy Integration of high-content imaging with translational studies Focus on ovarian, breast, and pediatric cancers AI-driven analysis of drug sensitivity data Recent articles demonstrate: 3D tumor spheroid platforms for drug testing Epigenetic regulators in neuroblastoma Microfluidics for high-throughput assays Cancer-stroma interactions in treatment resistance Clinical validation of precision diagnostics He co-organizes the Overview Course in Cancer Drug Discovery at KI and leads projects funded by the Swedish Childhood Cancer Foundation.

• Biogeochemistry
• Microbiology
• Soil Science
• +۳ مورد دیگر

Ferran Garcia-Pichel is a Regents Professor and Center Director at Arizona State University’s School of Life Sciences, affiliated with the Biodesign Center for Fundamental & Applied Microbiomics, Center for Biodiversity Outcomes, Water Institute, and Global Drylands Center. He holds a PhD in Microbiology from the University of Oregon (1999) and has been a faculty member at ASU since 1999. His research focuses on microbial adaptations in arid environments, including biogeochemical cycling, soil crust formation, and sustainable land restoration. Key interests include cyanobacterial sunscreen compounds (scytonemin), carbonate dissolution mechanisms, and hydrogen production. Teaching responsibilities include advanced microbiology, microbial ecology, and geomicrobiology courses such as MBB 495 Undergraduate Research and BIO 493 Honors Thesis. Awards span from the 2021 Regents Professor distinction to the 2023 Sperry Award for restoration science. His lab explores interdisciplinary approaches to study microbial communities in desert soils, marine intertidals, and atmospheric dust, with applications in climate resilience and biomedicine. Research highlights include biocrust restoration strategies, microbial nitrogen fixation networks, and the role of GABA/Glu signaling in spatial organization. Collaborations address global challenges like fugitive dust mitigation and carbon sequestration. The lab is based at the Biodesign Building B on ASU’s Tempe campus.