معرفی
Amy E. Fraley is an Assistant Professor at ETH Zürich, Department of Chemistry and Applied Biosciences, and leads the Medicinal Chemistry Research Group. Her cross-disciplinary work bridges natural products biosynthesis, pharmaceutical sciences, and environmental sustainability through enzymatic chemistry and biotechnology.
- BSc in Chemistry, Millersville University of Pennsylvania (2014)
- PhD in Medicinal Chemistry, University of Michigan College of Pharmacy (2019)
- Postdoctoral work at ETH Zürich Institute of Microbiology under Prof. Jörn Piel
Her research focuses on harnessing biosynthetic enzymes (e.g., halogenases, monooxygenases, Diels-Alderases) to create sustainable bioactive metabolites. She explores natural product biosynthesis in fungi and marine bacteria, targeting disease mechanisms and green chemistry applications. Recent work includes metagenomic studies of Lake Chilika microbial mats and polyketide synthase engineering.
Notable scientific awards include the 2024 JSP Fellow at Bürgenstock Conference, 2018 Rackham Predoctoral Fellowship, and multiple University of Michigan honors. Her group secured funding from the ETH4D Doctoral Mentorship Grant and Messerli Foundation.
Collaborations span structural biology, synthetic chemistry, and microbiology, with key contributions to flavoenzyme characterization and bioactive compound libraries. The lab emphasizes interdisciplinary training and innovation in biocatalytic tools for organic synthesis.
