Alan Boyle

Alan Boyle serves as an Assistant Professor in the Department of Computational Medicine and Bioinformatics within the University of Michigan Medical School. His research integrates computational genomics and wet lab experimentation to decode transcriptional regulatory mechanisms in human cells, with emphasis on how genetic variation influences disease susceptibility.

Dr. Boyle's primary research focus centers on gene regulation at the transcriptional level, investigating cis-regulatory elements and non-coding genomic regions. His laboratory employs:

• High-throughput sequencing techniques including long-read platforms
• Machine learning approaches for variant interpretation
• Massively parallel reporter assays for functional validation
• Integration of multi-omic datasets to map regulatory networks

Recent publication trends reveal expanding work on somatic mosaicism across tissues, tandem repeat disorders, and psychiatric disease mechanisms using cutting-edge nanopore sequencing. His group actively develops computational tools like GPatch for genome analysis while contributing to large consortia such as ENCODE.

Dr. Boyle maintains active mentorship with multiple trainees, including PhD candidate Kinsey (advanced August 2022) and recent lab members Rintsen, Katarina, Emily, and Hawra (joined May 2023). His research facilities span computational offices in Palmer Commons and wet lab space in Medical Science Building II, enabling comprehensive investigation of regulatory genomics.