معرفی
Martha L. Bulyk is a Professor of Medicine and Pathology at Harvard Medical School, with appointments in the Division of Genetics at Brigham & Women's Hospital. She serves as Co-Chair of the Harvard Biophysics Graduate Program and holds associate memberships at the Broad Institute of MIT and Harvard and the Dana-Farber Cancer Institute Center for Cancer Systems Biology. Her laboratory is located in the New Research Building at Harvard Medical School in Boston.
Her research focuses on decoding transcriptional regulation through the study of transcription factors (TFs) and DNA regulatory elements. Using integrated experimental and computational genomics approaches, her lab investigates:
- High-throughput analysis of TF-DNA binding specificities
- Cis-regulatory codes in eukaryotic genomes
- Effects of protein interactions and DNA structure on TF function
- Molecular determinants of protein-DNA binding specificity and evolution
- Impact of genetic variation on human transcription factors
- Pioneer factor interactions with nucleosomes
- Regulatory functions of alternative TF isoforms in breast cancer
- Quantitative information encoding in transcriptional enhancers/silencers
Recent publications demonstrate a strong focus on mechanistic studies of transcriptional regulation, with recurring themes in chromatin dynamics, cancer biology (particularly neuroblastoma and breast cancer), developmental gene regulation, and computational method development. Her work frequently integrates structural, evolutionary, and functional genomics approaches.
The Bulyk Laboratory currently comprises 2 graduate students, 3 postdoctoral fellows, 4 technicians, and 2 undergraduate students. The lab participates in multiple Harvard University programs including the Biophysics PhD Program, Biological & Biomedical Sciences (BBS) PhD Program, Systems/Synthetic/Quantitative Biology PhD Program, Bioinformatics & Integrative Genomics (BIG) PhD Program, and the School of Public Health Program in Quantitative Genomics.
