معرفی
Jussi Taipale is a Professor of Medical Systems Biology at Karolinska Institutet and holds professorships at University of Helsinki. His research focuses on transcription factor binding mechanisms, cancer genomics, and gene regulatory networks. The interdisciplinary Taipale Lab operates across three international locations: Wellcome Sanger Institute (UK), Karolinska Institutet (Sweden), and University of Helsinki (Finland), with over 20 members including senior scientists, postdoctoral fellows, and graduate students.
- Ph.D., University of Helsinki (1996)
- Postdoctoral training: University of Helsinki, Johns Hopkins University
Research spans transcription factor cooperativity, epigenetic regulation, chromatin accessibility, and noncoding mutation analysis. Key methodologies include HT-SELEX, CUT&RUN, ATI assays, and CRISPR-based functional genomics. The lab has significantly advanced understanding of Myc-driven oncogenesis, TF-nucleosome interactions, and dinucleotide specificity mechanisms.
Notable discoveries include chromatin context-dependent enhancers, water-mediated DNA recognition, and novel composite transcription factor motifs. The group maintains active collaborations across Europe and has trained numerous alumni now leading academic and industry positions worldwide.
