Adam Hume

Adam Hume is a Research Assistant Professor at the Chobanian & Avedisian School of Medicine, Boston University, specializing in Virology, Immunology & Microbiology. With a PhD from University of Wisconsin-Madison and BS from Bates College, he focuses on high-consequence pathogens requiring BSL4 containment, particularly filoviruses (Ebola, Marburg, Lloviu). His work addresses critical gaps in understanding

• pathogenic potential of newly discovered viruses
• host response mechanisms
• therapeutic targeting of host pathways
• reverse genetics for uncultivable viruses

through human organoid systems and iPSC-derived models.

His recent publications (2024-2025) span

• filovirus replication strategies
• antiviral drug synergy (DHODH inhibitors + 4'-fluorouridine)
• STAT3 signaling in RSV pathogenesis
• PARP14's dual antiviral role
• transcriptional regulation of Ebola mRNAs

with key collaborations at Boston University's Center for Regenerative Medicine and institutions like Emory University and NIH NIAID.

Recipient of NIH grants for

• intein-based filovirus research (1R21AI178560-01A1)
• antiviral countermeasures (1U19AI171403-01)

in addition to his Evans Center for Interdisciplinary Biomedical Research affiliation.

His methodological innovations include

• ViBE-Seq for 5' RNA sequencing
• recombinant Lloviu virus systems
• fluorescent viral labeling

advancing studies on previously inaccessible pathogens.