معرفی
Aastha Sindhwani is an Associate Research Scientist in Neuroscience at the Yale School of Medicine, Yale University. She holds primary appointment in Neuroscience and affiliation with Neuroscience Education & Training programs. Her research focuses on understanding cellular mechanisms involving lysosomal biology, host-pathogen interactions, and molecular processes governing intracellular bacterial replication. Sindhwani completed her PhD in Biological Sciences from the Indian Institute of Science Education and Research Mohali (2019) and MSc in Medical Biotechnology from the Post Graduate Institute of Medical Education & Research (2012).
Her work investigates lysosomal tethering factors like the HOPS complex and GTPases (Arl8/Arl8b) in contexts ranging from Salmonella pathogenesis to cellular stress responses. Key research areas include how pathogens exploit host cellular machinery, regulation of endolysosomal trafficking, and vitamin C's effects on genetically unstable cells.
Her publications span microbiology, cell biology, and molecular genetics, with notable contributions to understanding Salmonella's intracellular replication mechanisms and lysosomal signaling pathways. She collaborates within the Sestan Lab and contributes to translational research bridging basic science and clinical applications. Sindhwani's research has been published in journals like PLOS Pathogens, Journal of Cell Science, and Cellular Logistics.
