معرفی
Fabienne Paumet is a Professor in the Department of Microbiology & Immunology at Thomas Jefferson University's College of Life Sciences and serves as Co-Director of the Immunology & Microbial Pathogenesis PhD Program. Her research laboratory operates from the Bluemle Life Sciences Building in Philadelphia.
Her work focuses on molecular mechanisms of phagocytosis and pathogen subversion strategies, with key interests in:
- How intracellular bacteria (e.g., Chlamydia, Salmonella, Legionella) evade lysosomal degradation by manipulating host membrane trafficking
- Role of SNARE-like bacterial proteins in host membrane fusion interference
- Eukaryotic membrane fusion machinery characterization, including primitive SNARE systems and regulatory mechanisms
- Phagocytic processes in mast cells related to allergic responses
Recent publications demonstrate sustained focus on Chlamydia trachomatis pathogenesis, including membrane fusion dynamics in inclusion formation and bacterial exploitation of host cytoskeletal components. The 2024 Nature Communications article highlights specialized contact sites as critical regulators of chlamydial inclusion membrane fusion.
As Co-Director of the PhD program, Dr. Paumet mentors graduate students in immunology and microbial pathogenesis research. Her laboratory investigates fundamental host-pathogen interaction mechanisms with implications for infectious disease therapeutics.
Dr. Paumet maintains an active research group centered on intracellular bacterial pathogenesis, utilizing biochemical and cellular approaches to dissect membrane trafficking hijacking by pathogens.
