Norma W. Andrews

Norma W. Andrews is an Affiliate Professor at the Institute for Physical Science and Technology (IPST) and a Professor in the Department of Cell Biology & Molecular Genetics at the University of Maryland. Her research focuses on understanding molecular strategies employed by intracellular pathogens such as Trypanosoma cruzi and Leishmania to interact with host cells, with a particular emphasis on lysosomal exocytosis and plasma membrane repair mechanisms. Her work elucidates how pathogens subvert fundamental cell biological processes during infection, including lysosome-plasma membrane fusion and membrane damage repair.

Key research areas include the role of calcium-dependent lysosomal exocytosis in facilitating parasite invasion, the interplay between membrane damage and immune activation (e.g., B-cell responses), and the molecular mechanisms governing pathogen virulence. Notable findings include discoveries about acid sphingomyelinase release, endophilin-A2’s role in membrane repair, and the identification of iron-transport pathways critical for Leishmania survival within host cells.

Her publications span 2005–2023, with a focus on cellular repair mechanisms, pathogen invasion, and host-pathogen interactions. Andrews’ research bridges cell biology and parasitology, contributing to both fundamental science and potential therapeutic strategies against parasitic infections. No specific awards or grants are listed in the provided texts.