جست‌وجوی استاد و پژوهشگر

Benoit Arcangioliمشاهده پروفایل

پژوهشگر

• DNA repair
• Genome stability
• Cellular quiescence
• +۷ مورد دیگر

Benoit Arcangioli is a Researcher and Principal Investigator at the Institut Pasteur, affiliated with the Genomes and Genetics Department and the Genome Dynamics unit in Paris, France. He leads research projects on genome stability in quiescence and DNA methylation, using fission yeast as a model organism. Research Interests: His work focuses on understanding how DNA damage is repaired and how mutations arise in non-dividing (quiescent) cells, a state relevant to aging, cancer, and neurodegenerative diseases. He investigates epigenetic mechanisms such as DNA methylation and heterochromatin regulation, particularly in the context of cellular quiescence and genome dynamics. Publication Trends: His recent publications (2017–2023) reveal a strong focus on genome stability, mutagenesis in quiescent cells, epigenetic regulation, and DNA repair mechanisms in fission yeast. His research bridges molecular biology, genetics, and evolutionary biology, with implications for human aging and disease. Scientific Awards: No scientific awards mentioned in the provided text. Advising and Grants: Dr. Arcangioli has mentored several PhD students and postdoctoral fellows, including Célia Raimondi, Samia Miled, Rostyslav Makarenko, and Balveer Singh. He leads funded research projects such as 'Genome stability in quiescence' and 'Dynamics and biological function of deoxycytosine methylation' at the Institut Pasteur. Labs and Teams: He is part of the Genome Dynamics team within the Genomes and Genetics Department at the Institut Pasteur. His laboratory investigates the molecular mechanisms of quiescence, DNA repair, and epigenetic inheritance using *Schizosaccharomyces pombe* as a model system.

David Sychanthaمشاهده پروفایل

استادیار

• Microbiology & Immunology
• Antibiotics & Resistance
• Structural Enzymology
• +۳ مورد دیگر

Dr. David Sychantha is an Assistant Professor at the University of Waterloo, leading the Sychantha Lab focused on bacterial cell wall homeostasis and antibiotic resistance mechanisms. His research integrates structural biology, enzymology, and chemical biology to elucidate how pathogenic bacteria modify cell surfaces to evade immune systems and resist antibiotics. Key interests include autolysin regulation, metallo-β-lactamase inhibition, and peptidoglycan biosynthesis. Education: PhD in Molecular & Cellular Biology (2018), University of Guelph MSc in Molecular & Cellular Biology (2013), University of Guelph BSc in Microbiology (2011), University of Guelph CIHR Fellow (2020-2023), McMaster University Research Focus: The lab investigates biochemical pathways governing bacterial cell wall remodeling, with emphasis on autolysins and metallo-β-lactamases. Current projects target: Structural and functional analysis of enzymes involved in cell wall homeostasis Mechanisms of antibiotic resistance in carbapenem-resistant pathogens Design of novel inhibitors targeting virulence factors Awards: CIHR Fellowship Award (2020-2023) Michael G. DeGroote Fellowship Award (2018-2019) Lab & Collaborations: The Sychantha Lab actively collaborates on structural enzymology projects and currently accepts graduate student applications via the University of Waterloo admissions portal. Research outputs include high-impact studies on antibiotic adjuvants, enzyme inhibition mechanisms, and bacterial pathogenesis strategies.

Kate O'Connor-Gilesمشاهده پروفایل

استاد

• Neuroscience
• Synaptic Plasticity
• Molecular Genetics
• +۳ مورد دیگر

Kate O'Connor-Giles is a Provost's Professor of Brain Science at Brown University, affiliated with the Department of Neuroscience and the Carney Institute for Brain Science. Her research focuses on understanding synaptic communication and plasticity in neurons, employing advanced techniques like genetics, electrophysiology, and CRISPR-based genome engineering. She leads the O'Connor-Giles Lab, which develops innovative tools for studying synapses in vivo and contributes to open-access resources like the CRISPR Target Finder and FlyCRISPR platforms. Her work bridges molecular mechanisms and functional outcomes, investigating how neurons build and modulate synaptic connections over time. Key areas include autophagy regulation at ER-lysosome interfaces, transcriptional control of synaptic genes, and the role of calcium channels in synaptic diversity. The lab’s CRISPR tools have significantly advanced Drosophila genetics research, enabling precise genome editing and homology-directed repair. Publications highlight interdisciplinary approaches, from synaptic growth mechanisms to neurodegenerative pathways, emphasizing the interplay between molecular biology and neuronal function. Her lab’s reagents are shared via Addgene and the Drosophila Genomics Resource Center, fostering collaborative research globally.

• Functional genomics
• tRNA biology
• Microbiome
• +۴ مورد دیگر

Professor Tao Pan is a leading researcher in RNA biology at the University of Chicago's Department of Biochemistry and Molecular Biology. His laboratory pioneers methodologies for studying tRNA dynamics, epitranscriptomics, and microbiome-host interactions through innovative sequencing technologies. His research spans three interconnected domains: tRNA biology : Developing high-throughput sequencing to measure tRNA abundance, charging, and modifications, revealing roles in translational control and extratranslational functions Microbiome characterization : Creating tRNA-seq as an RNA-based alternative to 16S/shotgun metagenomics to capture dynamic microbiome activity Epitranscriptomics : Investigating mRNA modifications like m6A in gene regulation, discovering the 'm6A switch' mechanism affecting RNA structure and protein binding His publication trends demonstrate consistent innovation in RNA modification mapping techniques, with recent work focusing on nanopore sequencing applications, microbiome-induced epitranscriptomic reprogramming, and therapeutic mRNA engineering. Key recurring themes include tRNA modification dynamics, host-microbiome crosstalk, and RNA modification detection methodologies. Scientific recognition includes: NIH Director's Pioneer Award (2011-2016) NIH EUREKA Award (2009-2013) AAAS Fellow (2015) Multiple early-career cancer research awards His laboratory maintains substantial NIH funding through multiple R01 grants (current awards totaling >$5M annually), focusing on tRNA sequencing applications in cancer (R33CA272357), microbiome-host interactions (R21AI169280), and snoRNA functions (R01HG012780). The Pan Lab has established tRNA-seq as a novel microbiome characterization platform and pioneered discoveries in m6A-mediated RNA structural switching. Research infrastructure includes development of specialized sequencing technologies for simultaneous tRNA modification and fragmentation analysis, with recent expansion into nanopore-based direct RNA modification detection. Current work explores therapeutic applications of tRNA modification knowledge in cancer and infectious disease contexts.

Joe Louisمشاهده پروفایل

استاد

• Aphid Resistance
• Plant-Insect Interactions
• Plant Defense Mechanisms
• +۵ مورد دیگر

Joe Louis is the Eberhard Professor of Entomology in the Department of Entomology at the University of Nebraska-Lincoln, where he leads groundbreaking research on plant-insect interactions and crop resistance mechanisms. His work bridges molecular biology, chemical ecology, and agricultural science to address critical pest challenges in sorghum and related crops. Dr. Louis specializes in aphid resistance mechanisms, particularly in sorghum against pests like the sugarcane aphid ( Melanaphis sacchari ) and fall armyworm ( Spodoptera frugiperda ). His research explores phenylpropanoid pathways, cuticular wax composition, phytohormone signaling (jasmonic acid, abscisic acid), and genetic modifications that enhance plant defense. Key methodologies include transcriptomics, metabolomics, and high-throughput phenotyping to identify resistance traits. Analysis of his 15 most recent publications (2024-2025) reveals a dominant focus on sorghum-aphid interactions, with emerging work on fall armyworm defenses. Critical themes include the role of Brown midrib (BMR) mutants in resistance, the impact of epicuticular waxes on insect feeding behavior, and the function of specific genes (e.g., CCoAOMT, Zm4CL5) in defense pathways. His research demonstrates how plant age, phenology, and environmental factors modulate resistance efficacy. Scientific recognition includes: NSF CAREER Award (2019) for "Deciphering sorghum resistance mechanisms to phloem-feeding aphids" Dr. Louis's research program is supported by significant competitive grants, including the NSF CAREER award, which funds his work on molecular mechanisms of sorghum resistance. While specific advising details are not documented in available sources, his prolific publication output indicates active mentorship of graduate students in entomology and plant sciences. His work directly informs breeding programs for aphid-resistant sorghum varieties. Research is conducted within the Department of Entomology at the University of Nebraska-Lincoln, contributing to the university's agricultural research mission through collaborations with plant breeders, pathologists, and field entomologists. His laboratory integrates molecular techniques with field-based validation to ensure practical applications for sustainable pest management.

Ben Montpetitمشاهده پروفایل

استاد پژوهشی

• Molecular Biology
• Cell Biology
• RNA Processing and Export
• +۴ مورد دیگر

Ben Montpetit is a Principal Investigator at the University of California, Davis, in the Department of Viticulture & Enology. His research focuses on gene expression regulation in yeast, particularly mRNA export mechanisms, nuclear pore complex dynamics, and DEAD-box proteins like Dbp5. He holds a PhD from the University of British Columbia (2007) and conducted postdoctoral work at UC Berkeley and the University of British Columbia. Prior to UC Davis, he was an Assistant Professor at the University of Alberta’s Department of Cell Biology. His work integrates molecular biology, cell biology, and biophysics to study RNA processing pathways, with applications in understanding yeast biology and winemaking. Key interests include the interplay between SUMOylation, nuclear envelope biogenesis, and mitosis. His lab develops advanced imaging techniques, such as refractive index-matched media for live-cell microscopy, to visualize RNA-protein complexes in yeast. Recent studies address tRNA export mechanisms, mRNA-protein complex composition, and nuclear pore basket assembly linked to mRNA export. He secured an NSF-MCB/BSF grant (2022) for stoichiometry studies of mRNA-protein complexes. His research bridges fundamental cell biology with applied viticulture, analyzing Saccharomyces cerevisiae gene expression during wine fermentation at industrial scales.

Clay Jackson-Littekenمشاهده پروفایل

استادیار

• Acinetobacter pathogenesis
• Bacterial infections
• Microbiology

Clay Jackson-Litteken is an Assistant Professor in the Department of Microbiology and Immunology at the University of Arkansas for Medical Sciences (UAMS) College of Medicine. He holds a Ph.D. from UAMS and completed postdoctoral training at Washington University School of Medicine. His research focuses on Acinetobacter pathogenesis, particularly mechanisms of infection and antibiotic resistance. Research interests include: Molecular mechanisms of bacterial pathogenesis Antibiotic resistance in Gram-negative bacteria Host-pathogen interactions in respiratory and urinary tract infections Dr. Jackson-Litteken currently advises Ph.D., M.D./Ph.D., and M.S. students in microbial pathogenesis research.

• Biochemistry
• Chemical Biology
• Structural Biology
• +۵ مورد دیگر

Dr. Louise Walport is a Senior Lecturer in the Department of Chemistry at Imperial College London and a Group Leader at the Francis Crick Institute. Her research focuses on developing chemical tools based on cyclic peptides to study protein interactions in epigenetics and disease-related enzymes like protein arginine deiminases (PADI), with applications in drug discovery for conditions such as arthritis, multiple sclerosis, and cancer. Education: MChem in Chemistry from Magdalen College, University of Oxford (2009) DPhil in Chemical Biology from the University of Oxford (2014), supervised by Prof. Chris Schofield and Prof. Christina Redfield Louise's work leverages the RaPID system to screen vast peptide libraries (>10 13 molecules) for high-affinity binders, enabling targeted disruption of protein interactions. Her research spans Structural Biology , Chemical Biology , and Proteomics , with a focus on enzymology and epigenetic regulation. Recent publications highlight her expertise in cyclic peptide design for PADI4 inhibition and BET bromodomain targeting. Awards include the Global Marie Skłodowska-Curie Fellowship (2015). She collaborates across disciplines, utilizing facilities like Flow Cytometry and Electron Microscopy at the Crick Institute.

Pierre Chymkowitchمشاهده پروفایل

دانشیار

• Transcription
• Chromatin
• Cellular Differentiation
• +۵ مورد دیگر

Pierre Chymkowitch is an Associate Professor at the University of Oslo , affiliated with the Section for Biochemistry and Molecular Biology . His research focuses on the transcriptional and epigenetic regulation of cell fate and the dynamics of SUMOylation in chromatin remodeling during adipocyte differentiation . He employs advanced techniques such as ChIP-seq, RNA-seq, and confocal microscopy to study human and murine adipose stem cells, linking these mechanisms to obesity-related diseases like diabetes and cancer. Academic Rank: Associate Professor Institution: University of Oslo Section: Biochemistry and Molecular Biology Email: pierre.chymkowitch@ibv.uio.no Research Interests Transcriptional regulation in cellular differentiation SUMOylation-mediated chromatin dynamics Adipose tissue biology and obesity-related diseases Cell cycle and transcriptional homeostasis Epigenetic mechanisms in carcinogenesis Publication Trends Chymkowitch's recent work (2025) explores SUMOylation inhibition as a therapeutic target for metabolic disorders via TAK-981. Earlier studies (2023-2011) span mitotic chromatin resetting , Cdk1 regulation of transcription , and sumoylation in ribosomal gene expression , with a strong emphasis on interdisciplinary approaches bridging molecular biology and clinical applications. Laboratory & Team He leads the Chymkowitch group at the University of Oslo, collaborating on high-throughput genomic methods and classical biochemistry to unravel SUMOylation networks in developmental and disease contexts.

Jaap Broosمشاهده پروفایل

پژوهشگر

• Protein Biochemistry
• Biophysics
• Spectroscopy
• +۵ مورد دیگر

Jaap Broos investigates protein structure and function using biochemical and biophysical methodologies, with a focus on tryptophan fluorescence and phosphorescence. His work employs Trp analogs like 7-azatryptophan and 5-fluorotryptophan to study proteins such as the mannitol transporter (EII mtl ) from E. coli , domain 1 of transhydrogenase from Rhodospirillum rubrum , and LysM domains from Lactococcus lactis . Research highlights include developing a Lactococcus lactis expression system for Trp analog incorporation, enabling studies with reduced structural disruption. His team discovered that 5-fluorotryptophan exhibits monoexponential fluorescence decay, simplifying distance calculations in RET experiments. Collaborations with Prof. Callis (Montana State University) and Prof. Buma (Amsterdam University) have advanced theoretical and experimental understanding of Trp fluorescence dynamics. Key projects involve mapping the mannitol binding site in EII mtl using azi-mannitol and elucidating the 1L b emission state of Trp in rigid protein environments. Publications span journals like Methods Mol. Biol. , J. Am. Chem. Soc. , and Biophys. J. , reflecting interdisciplinary work in protein spectroscopy and engineering.

Hari Arthanariمشاهده پروفایل

دانشیار

• Structural Biology
• Biochemistry
• Biophysics
• +۵ مورد دیگر

Hari Arthanari is an Associate Professor in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School . His research focuses on protein-protein interactions and transcriptional Regulation in disease contexts, utilizing NMR spectroscopy , biophysical assays , and cell-based models . He operates the Arthanari Laboratory at Dana-Farber Cancer Institute, with a lab size of 5-10 members. Develops novel NMR methods for fragment screening and metabolite analysis Investigates transcriptional condensates and translation machinery dysregulation in cancer Applies integrative structural biology to therapeutic target discovery Research trends in his publications highlight therapeutic targeting of protein interactions across diverse diseases including cancer and viral infections . His work spans method development for NMR experiments, metabolomics marker identification , and structural characterization of both viral and human proteins. Articles frequently employ techniques like fluorine NMR , 15N TROSY experiments , and computational screening for drug candidate discovery. Scientific awards or formal recognition were not explicitly mentioned in the provided texts. His lab's publications emphasize collaborative multi-institute research and open-source drug discovery platforms , though no specific student advising or grant details were extracted. The Arthanari Lab (website: artlab.dana-farber.org) maintains focus on structural and functional characterization of proteins involved in disease mechanisms, particularly through NMR-derived metabolomics data and protein-ligand interaction identification .

• Molecular Biology
• Virology
• Biochemistry
• +۷ مورد دیگر

Leif Peter Sarin is an Adjunct Professor and University Lecturer in Molecular Biology at the University of Helsinki , affiliated with the Faculty of Biological and Environmental Sciences and Molecular and Integrative Biosciences Research Programme . He leads the RNAcious laboratory and supervises doctoral and Master’s students. Doctor of Philosophy in Molecular Virology (University of Helsinki, 2005-2010) Master of Science in General Microbiology (University of Helsinki, 2005) Title of Docent (Adjunct Professor) in Molecular Biology (University of Helsinki, 2014) His research focuses on post-transcriptional RNA modifications , transfer RNA , translation regulation , and host-pathogen interactions , with applications in synthetic biology and industrial biotechnology . Recent publications explore RNA sequencing methods, tRNA dynamics in marine bacteria, and roles of noncoding RNA in cancer. Scientific awards include the Sigrid Jusélius Fellowship 2012-2014 . Key projects: PROMOTE (2023-) and ProteRNA (2019-2025), funded by the Academy of Finland and Research Council of Finland. He has supervised doctoral and Master’s students, including Matea Radešić and Lampi, M. , and hosted international researchers like Jocelyne DiRuggiero . His work spans virology, biochemistry, and RNA biology, with over 33 publications and 72 collaborative activities.

Müller Christophمشاهده پروفایل

استاد پژوهشی

• Protein crystallography
• RNA polymerase transcription
• Integrated structural biology
• +۴ مورد دیگر

Christoph Müller is a Research Professor leading the Structural and Computational Biology Unit at EMBL Heidelberg since 2007. He previously served as Deputy Head at EMBL Grenoble (2000-2007) and has been a Senior Scientist at EMBL since 2000. His research focuses on protein crystallography, RNA polymerase mechanisms, and integrated structural biology. Key contributions include studies on RNA polymerases I/III transcription, chromatin modifying complexes, and transcription factor interactions. Education: PhD in X-ray Crystallography & Biochemistry (1991), University of Freiburg MSc in Chemistry & Biochemistry (1986), University of Freiburg Postdoctoral training at Harvard University (1992-1995) and University of Freiburg (1991) His work bridges structural biology with functional mechanisms, employing cutting-edge techniques like cryo-EM and X-ray crystallography. Major achievements include solving the structure of the 14-subunit RNA polymerase I and elucidating promoter-opening mechanisms in RNA polymerase III. Awards: ERC Advanced Investigator Grant (2013) EMBO Membership (2005) Steinhofer Award (2003) His research group investigates transcriptional regulation at molecular and structural levels, with recent work exploring BET protein interactions and tRNA modification pathways. Collaborations span structural biology, epigenetics, and developmental biology.

Patrick Caiمشاهده پروفایل

استاد

• Synthetic Biology
• Genetic Engineering
• Molecular Biology
• +۵ مورد دیگر

Patrick Cai is a Professor and MAE Chair in Synthetic Genomics at the University of Manchester's Manchester Institute of Biotechnology. His research focuses on synthetic biology, genetic engineering, and microbial systems. He holds editorial roles in journals like Nature Chemical Biology and has led major research initiatives including the ERC-funded 'Engineering Biology with Synthetic Genomes' project. Education: PhD in Chemical Engineering, Virginia Tech (2010) Postdoc Fellowship, Johns Hopkins University (2010-2013) MSc, University of Edinburgh (2006) BEng, Central South University of Technology (2005) Research Interests: Patrick's work spans synthetic genomics, metabolic engineering, and biocontainment strategies. His lab develops novel genetic tools for yeast and bacterial systems, with applications in biomanufacturing and sustainable biotechnology. Key areas include: Design of synthetic genetic circuits Engineering non-canonical amino acid incorporation Development of safe synthetic organisms Key Achievements: Recipient of the ERC Consolidator Award (2024) and EPSRC Open Plus Fellowship (2022). His work has been featured in over 200 news outlets and 800+ social media engagements.

Sebastian Baumgartenمشاهده پروفایل

پژوهشگر

• RNA modifications
• Parasitology
• Malaria
• +۱۲ مورد دیگر

Sebastian Baumgarten is the Head of the 'Parasite RNA Biology' Group at the Institut Pasteur, France, a position he has held since June 2021. He is affiliated with the Department of Biology of Host-Parasite Interactions. Previously, he was a post-doctoral researcher at the same institute from 2016 to 2021. His educational background includes a Ph.D. (2013–2016) and MSc (2012–2013) from the Red Sea Research Center at King Abdullah University of Science and Technology, Saudi Arabia, and a BSc (2009–2012) from the University of Tübingen, Germany. His research centers on RNA biology in malaria parasites, particularly focusing on RNA modifications such as m6A and tRNA methylation, epigenetic regulation, and post-transcriptional gene control in Plasmodium falciparum . He employs advanced genomic techniques including CRISPR, RNAseq, and ChIPseq to study gene regulation and immune evasion mechanisms in protozoan parasites. His recent publications reveal a strong trend in understanding how RNA modifications influence parasite development, stress response, and antigenic variation. His work bridges molecular parasitology with epitranscriptomics, contributing significantly to the understanding of gene regulation in malaria parasites. Notable scientific contributions include studies published in Nature Microbiology , mBio , EMBO Reports , and Life Science Alliance , focusing on m6A methylation, RUF6 ncRNA interactions, and cohesin-mediated gene repression. He has supervised or collaborated with several researchers including post-doctoral fellows, PhD students, and technicians within his team. His group is actively involved in uncovering the molecular mechanisms of parasite survival and immune evasion, with potential implications for antimalarial drug and vaccine development. The 'Parasite RNA Biology' group operates within the Institut Pasteur's ecosystem, leveraging interdisciplinary platforms for genomics, imaging, and functional analysis to advance understanding of malaria parasite biology.