جستجوی استاد راهنمای دانشگاهی

Daniel J. Siegwartمشاهده پروفایل

استاد

• Drug Delivery
• Nanotechnology
• Cancer Research
• +۶ مورد دیگر

Daniel J. Siegwart holds the W. Ray Wallace Distinguished Chair in Molecular Oncology Research and serves as Professor at the University of Texas Southwestern Medical Center. He maintains dual appointments in the Department of Biomedical Engineering and Department of Biochemistry, and is affiliated with the Simmons Comprehensive Cancer Center. Dr. Siegwart directs both the Program in Genetic Drug Engineering and the Drug Delivery Program in Biomedical Engineering, while also serving as Co-Director of the Chemistry and Cancer Program. Dr. Siegwart's research focuses on developing advanced lipid and polymer-based systems with precise control over structure and responsiveness for applications in drug delivery, imaging, genetic diseases, and cancer. His work spans nano-based drugs, personalized medicine, and cancer immunology, with particular emphasis on creating targeted delivery systems for nucleic acid therapeutics. His laboratory pioneers innovations in lipid nanoparticle technology, selective organ targeting (SORT) systems, and novel approaches to overcome delivery barriers for genetic medicines. Analysis of Dr. Siegwart's recent publications reveals a strong focus on advancing lipid nanoparticle technology for organ-specific delivery of nucleic acids. His research group has made significant contributions to understanding structure-activity relationships of ionizable lipids, developing multi-organ targeting strategies, and creating solutions for repeated administration of mRNA therapeutics. Current work emphasizes expanding delivery capabilities beyond the liver to target lungs, spleen, skeletal muscle, and skin for treating genetic diseases and cancer. National Academy of Inventors (NAI) Fellow (2024) National Academy of Medicine (NAM) Emerging Leaders in Health and Medicine (ELHM) Scholar (2024) Controlled Release Society (CRS) College of Fellows (2023) American Institute for Medical and Biological Engineering (AIMBE) College of Fellows (2022) Howard Hughes Medical Institute (HHMI) Gilliam Fellowship for Advanced Study (2021) Dr. Siegwart has secured significant research funding including the American Cancer Society Research Scholar award, CPRIT Scholar Award, and NIH funding. He has co-founded multiple biotechnology companies including Signify Bio, Jumble Therapeutics, and ReCode Therapeutics, translating his academic research into clinical applications. His laboratory maintains active collaborations with leading institutions and pharmaceutical companies to advance nucleic acid delivery technologies. The Siegwart laboratory operates as a multidisciplinary research team at the intersection of chemistry, materials science, and biomedical engineering. The group maintains state-of-the-art facilities for nanoparticle formulation, characterization, and in vivo testing, with particular expertise in lipid chemistry, polymer synthesis, and nucleic acid delivery. Current research directions include developing next-generation delivery systems for CRISPR-based gene editing, creating tissue-specific mRNA vaccines, and engineering novel approaches to treat genetic disorders and cancer.

Lydia Herzelمشاهده پروفایل

استادیار

• RNA Biology
• Molecular Biology
• Biochemistry
• +۳ مورد دیگر

Lydia Herzel is an Assistant Professor in the Department of Biochemistry at the Freie Universität Berlin, affiliated with the Department of Biology, Chemistry, Pharmacy. Her research focuses on RNA dynamics, particularly mRNA regulation in fungi and bacteria, combining biochemistry, bioinformatics, and molecular biology. She leads the Herzel Group, which explores co-transcriptional RNA regulation and its impact on gene expression outcomes. The group employs advanced RNA sequencing and biochemical techniques to study transcriptome diversity and regulatory mechanisms. Her work spans topics such as RNA splicing, mRNA decay, and the interplay between transcription and post-transcriptional processes. Key areas include understanding how regulatory mechanisms influence fungal pathogenesis (e.g., Candida albicans) and bacterial gene expression. She collaborates on projects involving synthetic biology, codon usage, and functional genomics. Recent studies highlight her group’s contributions to understanding spliceosome function in morphogenesis and the development of novel clathrin inhibitors. She actively mentors students, including Javier Callís Creus, a former bachelor’s thesis student. The lab seeks motivated researchers interested in integrating biochemistry, microbiology, and bioinformatics. Her research has been published in high-impact journals such as Nature Reviews Molecular Cell Biology , Nucleic Acids Research , and mBio . Her work bridges fundamental biology with biomedical applications, aiming to translate regulatory insights into therapeutic strategies.

Miten Jainمشاهده پروفایل

استادیار

• Nanopore Technology
• Single-Cell Techniques
• Computational Biology
• +۳ مورد دیگر

Miten Jain is an Assistant Professor in the Department of Bioengineering at Northeastern University, with a joint appointment in the Department of Physics. His research focuses on nanopore technology, single-cell analysis, and computational biology, aiming to advance genomic and transcriptomic sequencing methodologies. He holds a PhD in Bioinformatics and Biomolecular Engineering from the University of California-Santa Cruz (2017). Dr. Jain leads research projects including 'Characterization of paired tumor and normal cell lines using long read sequencing' (NIST, 2021) and 'Multi-platform, high-coverage, long read sequencing of reference human genomes' (NIST, 2020). His work bridges engineering, physics, and biology, with applications in clinical diagnostics and space microbiology. He was recognized as a top 2% most-cited scientist globally in 2024 by Stanford University. His research outputs span epigenetic profiling, nanopore sequencing innovations, and space-based microbiome analysis. Recent studies include CRISPR-based therapeutic screening for glioma and real-time microbial profiling aboard the International Space Station. Collaborations with institutions like NIST and NASA highlight his interdisciplinary impact. Grants and awards include funding from NIST and recognition for ultra-rapid genome sequencing in critical care settings. His lab focuses on developing scalable, high-resolution genomic tools with applications in precision medicine and fundamental biology.

• Protein Synthesis Mechanisms
• Translation Elongation/Termination
• Systems Biology
• +۳ مورد دیگر

Professor Ian Stansfield is a Personal Chair in the School of Medicine, Medical Sciences and Nutrition at the University of Aberdeen. He holds a BSc (Hons) in Microbiology and a PhD in Biochemistry from the University of Sheffield. His research focuses on protein synthesis mechanisms in eukaryotes, translation elongation/termination, and systems biology approaches to model these processes. Collaborations with Prof M.Carmen Romano integrate mathematical modeling to study translation dynamics and synthetic biology applications. Teaching roles include coordinating MSc programs in Biotechnology, Bioinformatics, and Biobusiness, as well as undergraduate modules in Microbiology and Molecular Biology. He led successful iGEM teams, achieving Gold and Silver medals for developing diagnostic systems for neglected tropical diseases using synthetic biology. Key research areas include translational stress management during protein expression, bioinformatic analysis of mRNA sequences, and optimizing yeast as a protein expression system. Notable grants include BBSRC funding for synthetic gene circuits and systems biology analysis of translation termination factors. Scientific awards include iGEM Gold Medals (2009, 2014) and a Silver Medal (2010), with the 2014 entry winning Best Health and Medicine and Best Measurement Device awards. His work spans over 40 peer-reviewed publications, exploring topics from ribosomal pausing to tRNA properties in codon usage. Leadership roles include Director of Research in his School, overseeing research strategy and NHS partnerships. External roles include membership on BBSRC panels and the BioProNet management board, reflecting his influence in biotechnology and bioenergy sectors.

Kelly Riceمشاهده پروفایل

دانشیار

• Microbiology
• Bacterial Pathogenesis
• Space Biology
• +۴ مورد دیگر

Dr. Kelly Rice is an Associate Professor in the Department of Microbiology & Cell Science at the University of Florida. Her research focuses on bacterial physiology, particularly under extreme conditions such as microgravity, and mechanisms of bacterial pathogenesis, including biofilm formation, quorum sensing, and virulence factor regulation. She investigates how environmental stressors influence microbial behavior, with a focus on species like Streptococcus mutans and Staphylococcus aureus . Her work includes studies on the molecular mechanisms of programmed cell death in bacteria, the impact of spaceflight on bacterial metabolism, and the development of antibacterial materials using lignin derivatives. Dr. Rice’s research also explores the transmission of oral bacteria to fetal tissues during late gestation, highlighting the intersection of microbiology and clinical applications. Publications span topics such as the Cid/Lrg system’s role in Streptococcus mutans metabolism, microgravity-induced proteomic changes in pathogens, and the use of confocal microscopy to analyze biofilm structures. Her contributions advance understanding of bacterial adaptation to environmental stress and translational applications in antimicrobial strategies.

Alexey Petrovمشاهده پروفایل

دانشیار

• Translational Biology
• Ribosome Function
• Protein Synthesis
• +۷ مورد دیگر

Alexey Petrov is an Associate Professor in the Department of Biological Sciences at Auburn University, affiliated with the College of Sciences and Mathematics. His research focuses on the molecular mechanisms of protein synthesis, particularly ribosome dynamics and translational regulation. His research interests lie at the intersection of biochemistry, biophysics, and molecular biology. He investigates how ribosomes achieve high-speed and high-fidelity protein synthesis, how mRNA structure and modifications regulate translation, and how viral elements hijack the translational machinery. His lab employs cutting-edge single-molecule fluorescence techniques and biochemical assays to dissect these processes in real time. The recent publications highlight a strong focus on ribosome translocation, initiation, elongation fidelity, and the impact of mRNA modifications such as 2′-O-methylation and m6A on translation dynamics. His work frequently involves the study of viral internal ribosome entry sites (IRES), providing insights into alternative translation mechanisms. The research is characterized by a deep mechanistic and kinetic understanding of translation, often revealing multiple parallel pathways and dynamic conformational changes. Alexey Petrov received his B.S. from Moscow State University, Russia, followed by a Ph.D. from the University of Maryland, College Park, under Dr. Jonathan Dinman. He completed his postdoctoral training with Dr. Joseph D. Puglisi at Stanford University, where he pioneered single-molecule studies of translation. Postdoctoral fellow with Dr. Joseph D. Puglisi, Stanford University Ph.D. with Dr. Jonathan Dinman, University of Maryland, College Park B.S., Moscow State University, Russia He leads an active research group within Auburn University's Biophysics Cluster, established in 2017. His lab is dedicated to advancing the single-molecule toolbox by developing new instrumentation and data analysis pipelines to make these powerful techniques more accessible. While specific grants are not listed, his publication record in top journals suggests a well-funded and productive research program. He mentors students and postdoctoral researchers in biochemical and biophysical methods, contributing to the training of the next generation of scientists.

Anne Willisمشاهده پروفایل

استاد

• Post-transcriptional Control
• RNA-binding Proteins
• Toxicology
• +۴ مورد دیگر

Anne Willis is a Professor and Director of the MRC Toxicology Unit at the University of Cambridge, School of the Biological Sciences. Her research focuses on post-transcriptional control mechanisms in toxic injury, particularly involving RNA-binding proteins, regulatory RNA motifs, and tRNAs. She leads the Post-transcriptional control of gene expression following toxic injury program and collaborates on the Fibre Toxicity initiative. Biography Highlights : PhD in Biochemistry (University of London), Fellowships at BBSRC, EMBO member (2015), OBE (2017) Research Themes : Predictive adverse outcome models for toxicology, off-target effects of therapeutic RNAs, translational regulation in cancer Funding : Wellcome Trust LEAP grant, MRC (via Nucleic Acid Therapy Accelerator), Cancer Research Technologies Techniques : Mass spectrometry, Ribosome/polysome profiling, RBPome profiling Scientific Awards : OBE (2017) - Services to biomedical sciences and women in science BBSRC Advanced Fellowship (2000-2005) BBSRC Professorial Fellowship (2009-2013) EMBO membership (2015) Contact : tls36@cam.ac.uk | enquiries@mrc-tox.cam.ac.uk

George Garciaمشاهده پروفایل

استاد

• Medicinal Chemistry
• Biochemistry
• RNA Modifications
• +۴ مورد دیگر

George Garcia is a Professor in Medicinal Chemistry at the University of Michigan, focusing on RNA modifications, tuberculosis treatment, and enzyme catalysis. His research spans structural biology and drug development. Key affiliations: University of Michigan Research areas: tRNA guanine transglycosylase, rifamycin derivatives, queuine modification, and long-acting drug delivery systems. His work includes designing novel benzoxazinorifamycins for tuberculosis therapy and synthesizing tritium-labeled probes for RNA modification studies. Publications range from 1996 to 2022, showing sustained contributions to medicinal chemistry and RNA biology.

Betty Leiboldمشاهده پروفایل

استاد

• Iron Metabolism
• Cellular Iron Regulation
• Iron Regulatory Proteins
• +۳ مورد دیگر

Betty Leibold is a Professor at the University of Utah in the Department of Internal Medicine . Her research focuses on iron metabolism , diabetes , and mitosis , with a particular emphasis on iron regulatory proteins (IRPs) and their role in cellular homeostasis. Education: B.S., State University of New York Ph.D., Massachusetts Institute of Technology Research Interests include understanding how eukaryotic cells sense and respond to iron, the mechanisms of IRP2 regulation via ubiquitin ligases and phosphorylation, and the link between iron dysregulation and diseases like diabetes and neurodegenerative disorders. Her lab employs Caenorhabditis elegans and transgenic mice models to study these pathways. Publications highlight her work on IRP2's role in iron-dependent tRNA modification, HIF-1 regulation of iron homeostasis in worms, and the molecular mechanisms of IRP2 degradation. Keywords span iron metabolism , protein regulation , cell signaling , genetic models , and disease pathogenesis .

• Antimicrobial Resistance
• Bacteriophage biology
• Biochemistry
• +۴ مورد دیگر

Professor Tim Blower is an Honorary Professor in the Department of Biosciences at Durham University and a member of the Biophysical Sciences Institute Executive Board. His research focuses on toxin-antitoxin systems and bacteriophage interactions, exploring molecular mechanisms of bacterial defense against phages and their implications for antimicrobial resistance. He employs structural biology, biochemistry, and genetic approaches to study these systems. Key research interests include: Antimicrobial resistance mechanisms Phage-host interactions and defense systems Structural analysis of bacterial toxins and enzymes Molecular basis of phage immunity Toxin-antitoxin system regulation His work has led to significant contributions, including studies on the BREX defense system, nucleotidyltransferase toxins, and Mycobacterium tuberculosis pathogenesis. He has been awarded the Lister Institute Prize Fellowship (2019) and the Springboard Award (2017). Prof. Blower supervises a team of PhD students, including Aditi Biswas, Beth Hardman, and Tom Arrowsmith, among others. His research group investigates topics such as phage defense modularity, tRNA modification by toxins, and structural engineering of bacterial defense proteins.

Ian A Grahamمشاهده پروفایل

استاد

• Plant Biochemistry
• Metabolic Genetics
• Terpenoid Biosynthesis
• +۷ مورد دیگر

Professor Ian A Graham FRS is the Weston Chair of Biochemical Genetics in the Department of Biology, University of York , and leads the Centre for Novel Agricultural Products (CNAP). His research focuses on plant metabolic genetics, particularly the biosynthesis of medicinal and industrial compounds in crops such as Artemisia annua (artemisinin), opium poppy (morphine, noscapine), and industrial hemp (fatty acids). His educational background is not detailed in the source text, but his extensive research portfolio and leadership role suggest a PhD and postdoctoral training in plant biochemistry or molecular genetics. Graham’s research centers on plant specialized metabolism , using biochemical genetics to dissect pathways for terpenoids (artemisinin, diterpenoids) and alkaloids (noscapine, morphine). His work has enabled the development of high-yielding Artemisia annua hybrids for robust artemisinin supply and high-oleic hemp varieties. He integrates genomics, transcriptomics, and bioinformatics to discover gene clusters and engineer metabolic pathways. His team also studies seed oil mobilization and lipid metabolism in model systems like Arabidopsis . His recent publications reveal a strong focus on terpenoid biosynthesis , particularly diterpenoids in Euphorbia species, sesquiterpenes in Artemisia , and the evolution of metabolic gene clusters. There is also ongoing work on alkaloid pathways in Papaver , enzyme discovery, and metabolic engineering in heterologous hosts like Nicotiana benthamiana . Scientific Awards: Fellow of the Royal Society (FRS) Advising and Grants: Graham leads a research group with numerous publications involving collaborators and postdocs. He has secured major research funding from UKRI BBSRC, Defra, Innovate UK, the Bill & Melinda Gates Foundation, Medicines for Malaria Venture, and industrial partners such as Croda and Sun Pharmaceutical. His Prosperity Partnership with Croda and involvement in the Centre for High Carbon Capture Cropping (CHCx3) highlight strong industry and policy engagement. Labs and Teams: He directs the Centre for Novel Agricultural Products (CNAP) at the University of York, a research hub focused on sustainable crop improvement using biotechnology. His lab combines molecular genetics, biochemistry, and bioinformatics to advance plant natural product research.

Marlene Oeffingerمشاهده پروفایل

دانشیار

• RNA Processing
• Ribosome Biogenesis
• Neurodegenerative Diseases
• +۳ مورد دیگر

Marlene Oeffinger is an Associate Professor at the Faculty of Medicine, University of Montreal and holds a cross-appointment at the Division of Experimental Medicine, McGill University . She serves as Research Director of the Ribonucleoprotein Biochemistry Research Unit at the Montreal Clinical Research Institute (IRCM). Her research focuses on RNA maturation pathways, ribosome biogenesis, and their links to neurodegenerative diseases like Alzheimer's and ALS through RNA-protein complex dynamics. Education : Master's in Cell Biology (University of Vienna), PhD in Molecular Biology (University of Edinburgh). Training : Postdoctoral work in David Tollervey's lab (Edinburgh) and Mike Rout's lab (Rockefeller University). Her work combines proteomics , biochemical assays , and computational approaches to map RNA maturation networks and their connections to DNA damage repair. Recent articles highlight discoveries in archaeal ribosome evolution, mRNA export mechanisms, and RNA structure probing in yeast. She has received prestigious awards including the CIHR New Investigator Award , FRQ-S Junior Scholar Fellowships , and Revson Foundation Biomedical Fellowship . Marlene's lab trains students and researchers in RNA biology, with current members like Master's student Mauricio Hernandez Magana. Her affiliations span multiple platforms at the IRCM, including bioinformatics , proteomics , and molecular biology . She leads grants from CIHR , FRQNT , and Brain Canada , advancing understanding of RNA's role in disease etiology.

Sabine A. Fuchsمشاهده پروفایل

استاد

• Metabolic Diseases
• Genetic Diseases
• Pediatrics
• +۵ مورد دیگر

Sabine A. Fuchs is a Full Professor and pediatrician specializing in metabolic diseases at Utrecht University Medical Center (UMC-Utrecht), holding a Principal Investigator position at the Hubrecht Institute's Regenerative Medicine and Stem Cell Research group (RMCU). Her dual clinical-research role bridges patient care with translational science in pediatric genetic disorders. Her academic journey includes cum laude degrees in Pharmacy and Medicine from Utrecht University, supplemented by research in Edinburgh (Prof. Webb) and clinical training at Harvard Medical School. She completed pediatric specialization alongside a ZonMW AGIKO-funded PhD in metabolic diseases, later establishing her independent research line through a ZonMW Klinische Fellows grant. Dr. Fuchs' research centers on metabolic and genetic diseases in children, with emphasis on mitochondrial disorders and inborn errors of metabolism. She pioneers mRNA-based therapeutics, in vivo gene correction, and mitochondrial function restoration, developing innovative platforms like liver organoids for disease modeling. Her work integrates clinical insights with molecular diagnostics to address unmet therapeutic needs. Recent publications reveal strong trends in mRNA delivery systems for genetic diseases, aminoacyl-tRNA synthetase deficiency treatments, and advanced cellular screening for variant interpretation. Her group's work on mitochondrial phenotyping and amino acid metabolism demonstrates a multidisciplinary approach spanning nanomedicine, stem cell biology, and metabolic engineering. Her 2024 awards include: €200,000 Biotech Booster grant for HeLLO €150,000 ERC Proof of Concept grant for IMPACT €1.5 million ZonMW VICI grant for in vivo gene correction €15,000 Tjallingh Roorda Stichting grant for mitochondrial disease therapies Dr. Fuchs supervises PhD candidates through grants like the Tjallingh Roorda project and leads collaborative research funded by ZonMW, ERC, and Dutch foundations. Her grants portfolio exceeds €2 million in 2024, supporting translational pipelines from basic discovery to clinical application. She directs a research team within the RMCU at the Hubrecht Institute, collaborating with UMC-Utrecht clinicians and international partners to advance regenerative medicine approaches for childhood metabolic disorders through stem cell models and gene editing technologies.

• Structural Biology
• Computational Biology
• Molecular Biophysics
• +۴ مورد دیگر

Bojan Zagrovic is a Professor at the Department of Structural and Computational Biology , University of Vienna. His research focuses on the interplay between protein structure, RNA interactions, and molecular dynamics, particularly in phase separation, enzyme mechanisms, and disease-related mutations. Key research areas: Structural Biology, Computational Biophysics, RNA-Protein Interactions, Phase Separation, and Protein Aggregation. Recent work includes studying FUS RGG3 phase separation, α-mannosidase pathophysiology, and SPOC domain interactions. His publications span molecular dynamics simulations, RNA modifications (e.g., N6-methyladenosine), and structural insights into ciliary proteins like CFAP410. He teaches courses in computational structural biology, molecular biophysics, and quantitative biology.

Paul Jaschkeمشاهده پروفایل

مدرس ارشد

• Synthetic Biology
• Molecular Biology
• Genome Engineering
• +۷ مورد دیگر

Paul Jaschke is a Senior Lecturer in Synthetic Biology at Macquarie University's School of Natural Sciences, affiliated with the Centre of Excellence in Synthetic Biology. He holds a PhD from the University of British Columbia and completed postdoctoral research at Stanford University. His work focuses on bacteriophage engineering for antimicrobial therapies, overlapping genes, and genetic code expansion to combat antibiotic resistance. Education: PhD in Microbiology and Immunology, University of British Columbia NSERC-funded Postdoctoral Fellowship, Stanford University Research Interests: Engineering bacteriophages (T4, T7) for targeted therapy against uropathogenic E. coli Functional roles of overlapping genes in genome evolution Designing synthetic genetic codes for biocontainment and orthogonal translation systems Recent Article Trends: Recent publications emphasize phage-based antimicrobial strategies, synthetic gene design, and viral-host interactions in chemotrophic environments. Key themes include biocontainment systems, host response mechanisms, and modular genome engineering. Awards: People's Choice Award – BioInnovation Initiative Conference (2024) Inter-Departmental Collaboration Award (2022) Advising & Grants: Supervised 9 MRes and 8 PhD students. Active in projects like the International Genetically Engineered Machine (iGEM) Competition and phage therapy development. Lab alumni work at institutions like Harvard Medical School and companies like EnGeneic. Labs/Teams: Leads a research group within the School of Natural Sciences, collaborating with the Centre of Excellence in Synthetic Biology on interdisciplinary projects.