جست‌وجوی استاد و پژوهشگر

Saverio Brognaمشاهده پروفایل

دانشیار

• RNA Biology
• Molecular Biology
• Cell Biology
• +۳ مورد دیگر

Dr. Saverio Brogna is a Reader in RNA Biology at the University of Birmingham's School of Biosciences. His research focuses on RNA processing mechanisms, nonsense-mediated mRNA decay (NMD), and ribosomal functions within the nucleus. He leads a research group investigating the interconnections between pre-mRNA processing, translation, and mRNA stability. Brogna has held prestigious fellowships from the Wellcome Trust and Royal Society, enabling independent research since 2000. Education: Laurea (MA) in Biological Sciences (University of Pavia), PhD in Genetics (Cambridge University). Career path includes postdoctoral work at Brandeis University (USA) under Michael Rosbash. He teaches eukaryotic gene expression and cell biology modules, and supervises graduate/undergraduate students. His lab utilizes Drosophila and Schizosaccharomyces pombe models, with a focus on visualizing nascent RNA processing and nuclear ribosome roles. Key research areas include: 1) NMD mechanisms linking splicing to translation, 2) nuclear ribosome localization and function, and 3) development of chromosomal visualization techniques. Lab facilities include the Birmingham Fly Facility. Brogna actively recruits PhD/postdoc researchers and maintains an open lab portal on Facebook. Scientific awards include the Wellcome Trust Travelling Fellowship (2000) and Royal Society Research Fellowship (2004-2013). His work has been published in Nature Structural & Molecular Biology , EMBO Journal , and RNA .

Juannan Zhouمشاهده پروفایل

استاد

• Quantitative Biology
• Evolutionary Biology
• Genotype-Phenotype Mapping
• +۳ مورد دیگر

Juannan Zhou is a Professor in the Department of Biology at the University of Florida , where they recently established their research lab. Their work focuses on genotype-phenotype mapping using machine learning , mathematical modeling , and wet lab experiments to understand evolutionary dynamics. Research Lab : Department of Biology, University of Florida Contact : juannanzhou@ufl.edu Key research themes include: Mapping genotype-phenotype relationships in diploid organisms Investigating protein fitness landscapes through unsupervised language models Developing machine-learning assisted directed evolution techniques Studying complex probability distributions over biological sequence spaces Exploring interactions between biochemical constraints and evolutionary outcomes Recent publications demonstrate technical innovations in: Gaussian process priors for sequence-function modeling Field-theoretic density estimation methods Higher-order epistasis analysis Nonparametric Bayesian approaches to biological sequence space Differentiable Smith-Waterman algorithms for sequence alignment The lab actively seeks postdocs, lab technicians, and graduate students interested in machine learning applications in population genetics and evolutionary modeling . Current projects include developing gpmap-tools for genotype-phenotype map visualization and implementing empirical variance component regression frameworks.

Mihaela Zavolanمشاهده پروفایل

استاد

• Computational RNA Biology
• Bioinformatics
• Systems Biology
• +۵ مورد دیگر

Mihaela Zavolan is a Full Professor at the Biozentrum, University of Basel, Switzerland, where she has held continuous faculty appointments since 2003 (Assistant Professor 2003-2008, Associate Professor 2008-2014, Full Professor 2014-present). She simultaneously serves as a Group Leader at the Swiss Institute of Bioinformatics since 2004, directing research on RNA regulatory networks. Her educational background includes: PhD in Computer Science, University of New Mexico (1996-1999) M.Sc. in Computer Science, University of New Mexico (1994-1996) M.D., University of Medicine and Pharmacy, Timisoara, Romania (1986-1992) Dr. Zavolan's research centers on computational RNA biology , with pioneering work in microRNA mechanisms, RNA splicing, RNA-binding proteins, and pre-mRNA 3' end processing. Her group integrates advanced computational modeling with high-throughput experimental data to dissect post-transcriptional gene regulation networks. Key methodological contributions include quantitative analysis of CLIP techniques and biophysical models of miRNA-mRNA interactions. Analysis of her publication record reveals consistent focus on developing and applying computational frameworks for RNA regulatory networks, with increasing emphasis on genome-wide mapping of RNA-protein interactions and quantitative modeling of regulatory dynamics. Her work bridges molecular biology, genomics, and systems biology through innovative algorithm development. Her major scientific awards include: ERC Starting Grant (2012) Young Investigator of EURASNET (2006-2009) Lita Annenberg Hazen Presidential Fellowship, The Rockefeller University (2001-2003) Presidential Fellowship, The Rockefeller University (2001) Burroughs Wellcome Fellow, The Rockefeller University (2000) Dr. Zavolan has secured competitive research funding including the ERC Starting Grant and maintains active grant support through her group leadership positions. She serves on editorial boards of Genome Biology, Bioinformatics, BMC Molecular Biology, and Cells, and has organized major conferences including the European Conference on Computational Biology (2012) and Computational RNA Biology Conference (2014). She leads parallel research groups at the Biozentrum (Computational and Systems Biology) and Swiss Institute of Bioinformatics (RNA regulatory networks), employing interdisciplinary teams that combine computational biology, molecular biology, and high-throughput data analysis to investigate RNA-mediated gene regulation mechanisms.

• Ribosome biogenesis
• Molecular Biology
• Genetics
• +۵ مورد دیگر

Dr. Dieter Kressler is a Senior Researcher at the Department of Biology , Faculty of Science and Medicine , University of Fribourg. Holding a PhD and serving as head of the proteomics platform , his work focuses on the molecular mechanisms of eukaryotic ribosome biogenesis. Email: dieter.kressler@unifr.ch ORCID: 0000-0003-4855-3563 Contact: +41 26 300 8645 Location: PER 05 building, Fribourg Research Interests include: Dedicated chaperones for ribosomal proteins Co-translational regulation of ribosomal protein expression Ubiquitin signaling in ribosome assembly RNA helicase roles in pre-ribosomal particles Structural dynamics of ribosome maturation Stress response coupling to translational control His 15 most recent publications (2025-2016) reveal a consistent focus on ribosome biogenesis, with key articles in eLife , Nature Communications , and Nucleic Acids Research . Research spans from thermal avoidance circuits in C. elegans to ubiquitin fusion mechanisms in yeast ribosomes , integrating structural biology, genetics, and biochemical approaches.

Pavlina Gregorovaمشاهده پروفایل

پژوهشگر

• Biochemistry, cell and molecular biology
• Biomedicine
• Microbiology and virology

Pavlina Gregorova is a Doctoral Researcher at the University of Helsinki , affiliated with the Faculty of Biological and Environmental Sciences and the Molecular and Integrative Biosciences Research Programme . Her work bridges biochemistry, molecular biology, and microbiology. Biochemistry, cell and molecular biology Biomedicine Microbiology and virology Research Interests focus on post-transcriptional RNA modifications, particularly their role in translation regulation and infection dynamics. Recent studies explore tRNA cleavage in extremophiles, RNA modifications in prostate cancer, and aging-related protein structural changes. Scientific Contributions include developing novel methods for RNA virus quantification, analyzing RNA modification landscapes, and characterizing enzyme-polymerization-based longevity controls. Her work spans Microorganisms , Nucleic Acids Research , and Molecular Cell . Fulbright Finland Foundation Travel Grant for Research Collaboration (2020) She actively supervises Master's theses and participates in international collaborations, including a research visit at Johns Hopkins University . Gregorova contributes to organizations like the RNA Society and Societas biochemica, biophysica et microbiologica Fenniae .

• Molecular Biology
• Genetics
• RNA Biology
• +۴ مورد دیگر

Kwon Young-Soo is an Assistant Professor at the Department of Integrative Bioscience and Biotechnology , Sejong University , with a focus on post-transcriptional gene regulation mechanisms. He earned his B.S. in Genetic Engineering from Korea University , M.S. and Ph.D. in Biochemistry from KAIST , and completed postdoctoral training in Genomics at the University of California, San Diego . Research Interests : Post-transcriptional gene regulation, protein-RNA interactions, transcriptome-scale analysis, microRNA function, and developmental biology. Key Contributions : Determined cleavage sites of pre-microRNAs via DGCR8 target site analysis; mapped AGO2 binding sites to delineate microRNA target networks; developed experimental tools like SLEC technology for RNA sequencing. Publications (15 most recent) span RNA splicing, stem cell proteomics, and regulatory RNA networks, with recent work on L1TD1's role in ribonucleoprotein condensates and U2AF1/ZRSR2 splicing dynamics. His lab, the Genomics Lab , employs next-generation sequencing and bioinformatics to study human embryonic stem cells and differentiation processes.

Jean Beggsمشاهده پروفایل

استاد پژوهشی

• RNA splicing
• Transcription mechanisms
• Biochemistry
• +۳ مورد دیگر

Jean Beggs is a Royal Society Darwin Trust Research Professor and Professor of Molecular Biology at the University of Edinburgh. Previously, she held positions as a Senior Research Fellow in Edinburgh's Department of Molecular Biology, a Fellow at Royal Society University Research, and a Lecturer at Imperial College, London. Her research focuses on RNA splicing mechanisms and their links to transcription, with contributions to biochemistry and molecular genetics. Her honors include the Royal Society's Gabor Medal (2003) and a CBE for services to science (2006). She is a Fellow of the Royal Society, Royal Society of Edinburgh, and a member of Academia Europaea. Her work explores the interplay between transcription and splicing, with notable studies on RNA polymerase pausing and spliceosome dynamics. No grants or advisees are listed here.

Stephen Raderمشاهده پروفایل

استاد

• Pre-mRNA splicing
• Spliceosome structure and function
• Evolutionary biology of splicing
• +۴ مورد دیگر

Stephen Rader is a Professor of Chemistry at the University of Northern British Columbia (UNBC) in Prince George, British Columbia. His laboratory investigates the biological function and mechanism of pre-mRNA splicing, with a particular focus on the extremophile red alga Cyanidioschyzon merolae , which thrives in volcanic hot springs at temperatures up to 60°C and pH as low as 0.5. Dr. Rader's research program examines fundamental questions about pre-mRNA splicing from an evolutionary perspective, including how splicing helps cells adapt to environmental changes, the pressures leading to intron loss in certain lineages, and the minimal set of splicing machinery necessary for cell viability. His lab has made significant discoveries, including that C. merolae completely lacks the U1 snRNP typically responsible for 5' splice site recognition. His recent publications (2012-2022) demonstrate a consistent research trajectory focused on spliceosome structure, function, and evolution across diverse organisms. The work spans molecular biology, structural biology, and evolutionary genomics, with particular emphasis on how reduced spliceosomes function in extremophile organisms. His research combines biochemical, genetic, and structural approaches to understand splicing mechanisms. Dr. Rader actively trains graduate students and postdoctoral researchers, welcoming enthusiastic and well-prepared students to join his dynamic team in Prince George. His laboratory has produced numerous publications in high-impact journals including PNAS, RNA, Journal of Molecular Biology, and Frontiers in Genetics.

Alper Akayمشاهده پروفایل

پژوهشگر ارشد

• RNA modifications
• Gene regulation
• Developmental biology
• +۳ مورد دیگر

Dr. Alper Akay is a UKRI Future Leaders Fellow and Principal Investigator at the University of East Anglia (UEA), leading the RNA (epi)Genetics Lab within the School of Biological Sciences. His work focuses on understanding how RNA modifications regulate gene expression during animal development, primarily using C. elegans as a model. He holds a BSc in Biology from Middle East Technical University, an MSc in Molecular Biology and Bioinformatics from the University of Amsterdam, and a PhD in Life Sciences from the University of Dundee. His lab develops methodologies to identify modified RNAs and studies their roles in germ cell development and metabolism. Current projects include investigating the functional role of RNA methylomes and splicing regulation in human cancers. His research is supported by a UKRI Future Leaders Fellowship. He mentors PhD and MSc students and collaborates internationally. Key achievements include pioneering studies on RNA modification dynamics under stress conditions and developing tools for genetic modification of plant-parasitic nematodes. Education: PhD in Life Sciences, University of Dundee (2007–2012) MSc in Molecular Biology and Bioinformatics, University of Amsterdam (2005–2007) BSc in Biology, Middle East Technical University (2000–2005) Awards: UKRI Future Leaders Fellowship (2020–present) Labs/Teams: RNA (epi)Genetics Lab, Cells and Tissues Group

Klemens J. Hertelمشاهده پروفایل

استاد

• Alternative Splicing
• RNA Processing
• Molecular Genetics
• +۳ مورد دیگر

Klemens J. Hertel is a Professor and Chair of the Department of Microbiology & Molecular Genetics at the University of California, Irvine School of Medicine. His research focuses on the molecular mechanisms of RNA splicing, particularly the regulation of alternative splicing events such as NAGNAG splicing and their implications in cancer and cellular processes. He has contributed extensively to understanding spliceosome dynamics, RNA processing, and the interplay between splicing and gene regulation. Key research areas include the influence of genetic and epigenetic factors on splicing efficiency, the role of RNA-binding proteins in splice site selection, and the impact of metabolic signals on alternative splicing. His work integrates biochemical assays, high-throughput sequencing, and computational modeling to uncover fundamental mechanisms in molecular genetics. Recent studies highlight his exploration of splicing defects in cancer progression, the regulatory networks governing spliceosome assembly, and the functional consequences of alternative polyadenylation. He has published over 50 peer-reviewed articles, with notable contributions to journals like Nucleic Acids Research and Molecular and Cellular Biology. Dr. Hertel’s grants include NIH funding (R01 GM062287, R21 CA149548) for projects on splicing regulation and cancer biology. His lab is at the forefront of developing in vitro splicing systems and tools for studying RNA processing. Mentorship of students and postdocs in molecular genetics and biochemistry underscores his commitment to training future scientists.

Ben Montpetitمشاهده پروفایل

استادیار مدعو

• Molecular Biology
• Cell Biology
• RNA Biology
• +۳ مورد دیگر

Ben Montpetit is an Adjunct Assistant Professor in the Department of Viticulture & Enology at the University of California at Davis, College of Agricultural and Environmental Sciences. His research focuses on the molecular mechanisms of mRNA export through nuclear pore complexes (NPCs) and its implications in cellular stress responses and human diseases. Ph.D., University of British Columbia Research Interests Montpetit’s work investigates how NPCs regulate mRNA export at cellular, molecular, and atomic levels. His lab employs cell biology , biochemistry , structural biology , and single-molecule imaging in Saccharomyces cerevisiae to elucidate transport mechanisms. Future directions include expanding studies to mammalian systems to link mRNA export defects to diseases like cancer and neurodegenerative disorders. Publication Trends Montpetit's articles span RNA biology , nuclear transport , and protein-RNA interactions , with a focus on DEAD-box ATPases, nucleoporins, and stress-regulated export pathways. His work bridges basic cell biology and clinical relevance , particularly in disease mechanisms. Lab Members The Montpetit Lab collaborates with a multidisciplinary team of undergraduates, graduate students, postdocs, and staff, leveraging yeast and mammalian models to advance mechanistic understanding of RNA transport and processing. Contact Email: benmontpetit@ucdavis.edu Office: Department of Viticulture & Enology, UC Davis Phone: 530-752-9355

Daniel Semlowمشاهده پروفایل

استادیار

• DNA Replication
• DNA Repair
• Nucleic Acid Chemistry
• +۴ مورد دیگر

Daniel Semlow is an Assistant Professor of Biochemistry at the California Institute of Technology (Caltech) and a Ronald and JoAnne Willens Scholar. He earned his B.S. from the University of Illinois, Urbana (2005) and his Ph.D. from the University of Chicago (2015). He served as a Visiting Associate at Caltech from 2019–2020 before joining as a faculty member in 2020. His research focuses on DNA replication and repair mechanisms, particularly those involving nucleic acid chemistry and genome maintenance. Education: B.S. in Biochemistry, University of Illinois, Urbana (2005) Ph.D. in Biochemistry, University of Chicago (2015) The Semlow Lab employs biochemical, genetic, and analytical methods to investigate how cells tolerate and repair DNA damage during replication. They also develop tools to identify novel DNA lesions and elucidate their origins. These studies aim to advance understanding of DNA repair pathways and potentially inform therapeutic strategies for cancer and genetic disorders. His publications highlight research on DNA interstrand crosslink repair, spliceosome dynamics, and RNA ligase deoxyribozymes. Key themes include DNA damage response, RNA processing, and enzyme activity. Collaborations with researchers like James C. Walter and others underscore interdisciplinary approaches to genome stability. Scientific Awards: Ronald and JoAnne Willens Scholar (2021–) As an instructor, Semlow contributes to Caltech’s BMB/Bi/Ch 174 course on advanced topics in biochemistry and molecular biophysics (2021–2024). He emphasizes literature analysis and synthesis of biochemical research.

Gideon Dreyfussمشاهده پروفایل

استاد

• RNA-binding proteins
• SMN complex
• Spinal Muscular Atrophy
• +۶ مورد دیگر

Gideon Dreyfuss is the Isaac Norris Professor in the Department of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania. He maintains an active research laboratory focusing on RNA biology and its implications for human disease. His work bridges basic molecular mechanisms with therapeutic applications, particularly in neurodegenerative disorders. Dr. Dreyfuss received his B.Sc. in Chemistry from The Hebrew University in Jerusalem (1973), M.Sc. in Biochemistry from Tel Aviv University (1975), and Ph.D. in Biological Chemistry from Harvard University (1978). His educational background provided the foundation for his pioneering work in RNA-protein interactions. His research primarily focuses on RNA-binding proteins, the Survival of Motor Neurons (SMN) complex, and their roles in spinal muscular atrophy and other neurodegenerative diseases. Dr. Dreyfuss has made seminal contributions to understanding the assembly and transport of RNA-protein (RNP) complexes, the exon-junction complex, and U1 snRNP telescripting. His laboratory employs high-throughput screening approaches to identify potential therapeutics for spinal muscular atrophy. The keywords that define his research include RNA, RNPs, SMN, spinal muscular atrophy, high throughput screening, neurodegeneration, and nuclear transport. Analysis of his recent publications (2013-2025) reveals a consistent focus on RNA-protein interactions, with particular emphasis on U1 snRNP functions in transcription regulation and telescripting. His work has evolved from basic characterization of RNA-binding proteins to therapeutic applications for neuromuscular diseases, demonstrating a clear trajectory from fundamental science to clinical relevance. Dr. Dreyfuss leads an active laboratory with numerous research associates, postdoctoral fellows, and specialists working on various aspects of RNA biology. His laboratory has been consistently funded through competitive grants, supporting research on SMN complex composition, function, and therapeutic targeting for spinal muscular atrophy. The Dreyfuss laboratory maintains a robust team structure with specialized personnel focusing on different aspects of RNA biology. Current lab members include research associates, postdoctoral fellows, and specialists working on SMN complex structure, U1 snRNP functions, and high-throughput screening for therapeutic compounds. The laboratory has established sophisticated methodologies for studying RNA-protein interactions and their implications for human disease.

• Molecular Biology
• RNA Biology
• Gene Expression Regulation
• +۳ مورد دیگر

Maria Alexandra Marques Moreira is an active Principal Investigator at the Abel Salazar Institute of Biomedical Sciences (ICBAS) of the University of Porto. She teaches Molecular Genetics for Veterinary Medicine and RNA Biology for Molecular Biology Complements. Moreira serves on the Scientific Council of the Molecular and Cellular Biology Doctoral Program and leads the Gene Regulation research group at IBMC/i3S since 2013. PhD in Molecular Biology from the University of Oxford, UK Degree in Biochemistry from the Faculty of Sciences, University of Lisbon Her research focuses on mRNA biology and gene expression regulation, particularly alternative pre-mRNA splicing and 3'UTR dynamics in health and disease. The group employs molecular and cellular biology methodologies to study physiologically relevant splicing events. Analysis of her 15 most recent publications reveals expertise in alternative polyadenylation , 3'UTR sequence regulation , gene expression in immune cells , and RNA biology in developmental and disease contexts . The work spans molecular mechanisms from Drosophila to human models, including applications in rheumatoid arthritis and colorectal cancer . Moreira has supervised multiple undergraduate, master's, and doctoral students, and over 40 international/national doctoral theses as an external reviewer. Her laboratory at IBMC/i3S actively engages students in experimental work. She has published extensively in peer-reviewed journals (1,900+ citations), holds patents in molecular biology, and contributes to book chapters. Her roles include coordinating continuing education courses on Advanced Light Microscopy and Global Climate Change impacts on immunity .

• RNA Biology
• Genomics
• Cancer Metastasis
• +۵ مورد دیگر

Traude Beilharz is a Professor at Monash University's Department of Biochemistry & Molecular Biology. She leads research into RNA metabolism in health and disease, focusing on eukaryotic systems using next-generation technologies and model organisms. Her work contributes to understanding human genetic code fundamentals and accelerating gene-function discovery. Research interests include RNA biology, genomics, and cancer metastasis. She explores mechanisms of mRNA processing, translational control, and their roles in disease. Notable projects include studying antifungal drug tolerance and mRNA vaccine development through collaborations in the ARC Centre of Excellence for Cellular Systems. Recent articles highlight her work on alternative polyadenylation in cancer, fungal pathogenesis, and mRNA dynamics. She has been honored with the Mercator Fellow award (2023). Her projects include leadership in mRNA clinical trials and pre-clinical innovation incubators.