جست‌وجوی استاد و پژوهشگر

Thomas Walterمشاهده پروفایل

استاد

• Biomedical Image Analysis
• Machine Learning
• Computational Pathology
• +۴ مورد دیگر

Thomas Walter is a Professor at Mines ParisTech and Director of the Centre for Computational Biology (CBIO) , a research group affiliated with the Institut Curie and INSERM . His work focuses on applying Machine Learning and Computer Vision to biomedical image analysis, particularly in high-content screening and computational pathology . He also serves as Deputy Director of the Computational Oncology (U1331) unit and leads the Statistical Learning and Modeling of Biological Systems team. PhD in Medical Image Analysis (2003, Mines ParisTech) Postdoctoral work at EMBL (European Molecular Biology Laboratory) Director of CBIO since 2018 Holder of a PRAIRIE Chair (Paris Artificial Intelligence Research Institute) since 2019 Dr. Walter's research bridges biomedical imaging , machine learning , and cancer genomics . Key areas include: Statistical reconstruction of biological networks Prediction of tumor progression at genomic/transcriptomic levels Development of deep learning methods for cell cycle analysis Integration of multi-omics data for precision oncology Tools for spatial transcriptomics (e.g., autoFISH, RNA2seg) Recent publications highlight his work in spatial transcriptomics , immunotherapy outcome prediction , and deep learning for digital pathology . His team has developed open-source tools like FISH-quant and pyHiM for single-molecule RNA imaging analysis. Scientific Honors: PRAIRIE Chair (2019) for AI research in life sciences Dr. Walter actively contributes to teaching deep learning for image analysis in multiple graduate programs across France, including courses at Mines ParisTech , Université Paris-Saclay , and Institut Curie . His software tools (FISH-quant, pyHiM) and methodological frameworks (e.g., Cut-Detector, PointFISH) have become standard resources in bioimage informatics.

Oded Regevمشاهده پروفایل

استاد

• Theoretical Computer Science
• Lattice-based Cryptography
• Quantum Computation
• +۳ مورد دیگر

Oded Regev is a Silver Professor at the Courant Institute of Mathematical Sciences, New York University. He has previously held positions at Tel Aviv University and École Normale Supérieure, Paris (CNRS). His research spans theoretical computer science, cryptography, quantum computation, and machine learning applications in biological discovery. Education: PhD in Computer Science, Tel Aviv University (2001) Regev is renowned for his work in lattice-based cryptography, including the introduction of the Learning With Errors (LWE) problem and Gaussian measures. He also leads research using interpretable machine learning to decode RNA splicing logic and nuclear speckle dynamics, with implications in disease and therapeutics. His recent articles focus on quantum factoring, RNA localization, and geometric lattice bounds. Scientific Awards: European Research Council (ERC) Starting Grant (2008) 2018 Gödel Prize 2019 Simons Investigator Award Best Paper Awards: STOC 2003, Eurocrypt 2006 Regev mentors students and postdocs in both theoretical computer science and computational biology. His lab has secured funding from NSF, NIH, and Additional Ventures. He co-founded the TCS+ online seminar series and serves as Associate Editor-in-Chief for Theory of Computing .

Adam Feinbergمشاهده پروفایل

استاد

• Biomedical Engineering
• Tissue Engineering
• 3D Bioprinting
• +۶ مورد دیگر

Adam Feinberg is a Professor in the Departments of Biomedical Engineering and Materials Science and Engineering at Carnegie Mellon University (CMU). He leads the Regenerative Biomaterials & Therapeutics Group, focusing on cell-material interactions, 3D bioprinting, and bioengineered tissues. His work integrates nanofabrication, molecular biology, and 3D imaging to address challenges in muscle repair, corneal regeneration, and cancer. Key innovations include the FRESH bioprinting platform, enabling soft ECM gel-based constructs, and ECM shrink-wrapping techniques for cell encapsulation. Feinberg holds a Ph.D. and MS in Biomedical Engineering from the University of Florida (2004, 2002) and a BS in Materials Science and Engineering from Cornell University (1999). He has secured major grants, including ARPA-H funding for diabetes treatments and Canada’s New Frontiers Fund for heart disease therapies. His research has led to over 45 peer-reviewed articles and 20 patents. His scientific awards include the NIH Director’s New Innovator Award and NSF CAREER Award. Media highlights include breakthroughs in vascularized tissue models and biodegradable actuators. Feinberg collaborates widely, advancing clinical translation of bioprinted tissues and sustainable bio-bots.

Michael J. Mitchellمشاهده پروفایل

دانشیار

• Biomaterials Science
• Drug Delivery
• Cancer Therapy
• +۷ مورد دیگر

Michael J. Mitchell is an Associate Professor in the Department of Bioengineering at the University of Pennsylvania. His research focuses on overcoming biological barriers to drug delivery through biomaterials science, nanotechnology, and cellular engineering. Key areas include mRNA lipid nanoparticle development for cancer therapy, immunotherapy, genome editing, and regenerative medicine. His lab has pioneered placental-targeted drug delivery for in utero treatments and developed scalable microfluidic manufacturing processes for vaccines. Education: PhD in Bioengineering (University of Pennsylvania) Postdoctoral Training in Nanomedicine Research Interests: Dr. Mitchell’s work integrates biomaterials with biological systems to improve drug delivery efficiency. Current projects include: Design of lipid nanoparticles for mRNA and CRISPR delivery Targeted therapies for cancer metastasis and cardiovascular disease Placenta-specific drug delivery systems for maternal-fetal health Bioengineered immune cell therapies using mRNA Recent Achievements: In 2021, his lab published breakthrough work on lipid nanoparticles improving mRNA vaccine stability, featured in Penn Today and MIT Technology Review . Collaborations with CHOP and Penn Medicine have advanced in utero mRNA delivery for congenital diseases. Awards & Grants: Recipient of NIH grants for nanomedicine research and industry partnerships for vaccine development. Active in translational projects with startup companies for clinical nanotechnology applications. Labs & Teams: Lead of the Mitchell Lab at Penn Engineering, which includes over 20 researchers focusing on nanomedicine, biomaterials, and clinical translation.

• Bioprocess Engineering
• Industrial Biotechnology
• Downstream Processing
• +۱۱ مورد دیگر

Alois Jungbauer is a full Professor and Head of the Institute of Biochemical Engineering at the University of Natural Resources and Life Sciences Vienna (BOKU), within the Department für Biotechnologie und Lebensmittelwissenschaften. He is a leading expert in bioprocess engineering, with a focus on downstream processing, continuous manufacturing, and sustainable biopharmaceutical production. Doctorate, University of Natural Resources and Life Sciences Vienna Habilitation, 1991 His research interests center on advanced purification technologies for biologics, including monoclonal antibodies, viral vectors, virus-like particles (VLPs), and gene therapy products. He is a pioneer in continuous integrated biomanufacturing, real-time process monitoring, and the development of platform processes for non-mAb proteins. His work integrates computational modeling, digital twins, and process intensification to improve efficiency and reduce environmental impact. He has made significant contributions to affinity chromatography, membrane adsorbers, and non-chromatographic separation methods. Recent publications highlight trends in continuous downstream processing, water conservation, in-situ buffer preparation, and the purification of complex biomolecules like secretory IgA and VLPs. His work spans both fundamental biophysical studies and industrial applications, reflecting a strong industry-academia interface. His scientific awards include: ISMR Thermo Fischer Award for Affinity Technologies (2011) Bia Separations Award (2000) Fulbright Award, Austrian-American Fulbright Commission (1996) Award of Japanese Society for Promotion of Science (1994) Golden Award 93 Professor Jungbauer actively supervises university theses and leads a dynamic research group. He has delivered numerous lectures and keynotes worldwide, indicating active engagement in knowledge transfer. His research is supported by ongoing projects and collaborations, with a strong emphasis on environmental and economic modeling of bioprocesses. He is affiliated with the Institute of Biochemical Engineering at BOKU, a hub for innovation in bioprocessing and industrial biotechnology.

Miler T. Leeمشاهده پروفایل

دانشیار

• Gene Regulation
• Developmental Biology
• Computational Genomics
• +۹ مورد دیگر

Miler T. Lee is an Associate Professor at the University of Pittsburgh , focusing on gene regulation during early embryonic development through high-throughput experimental and computational genomics. He earned his Ph.D. in Genomics and Computational Biology in 2009 from the University of Pennsylvania under Dr. Junhyong Kim, followed by postdoctoral work with Dr. Antonio Giraldez at Yale University. Joining the university in 2016, his research spans maternal-to-zygotic transition (MZT), RNA stability, pluripotency networks, and evolutionary developmental biology, utilizing model organisms like zebrafish, Xenopus, and Hydractinia symbiolongicarpus. Key Research Themes: Maternally inherited RNA dynamics during embryogenesis Mechanisms of RNA degradation and transcriptome remodeling Evolution of pluripotency networks in hybrid species Role of zinc signaling in fertilization barriers Computational tools for RNA regulation and sensing Scientific Awards: Pan-American Society for Evolutionary Developmental Biology Junior Faculty Award (2024) Outstanding New Investigator – International Xenopus Board (2023) Basil O'Connor Scholar – March of Dimes (2017-2019) Recent publications highlight his work on enhancer classification, RNA degradation mechanisms, and cross-species MZT comparisons. His lab develops innovative methods like RESA for regulatory sequence analysis and studies evolutionary divergence in RNA localization patterns. While the articles span computational and experimental approaches, they consistently address RNA's role in cellular identity, developmental timing, and evolutionary adaptation. Applications include understanding pluripotency, designing RNA biosensors, and elucidating fertilization barriers. Prospective Ph.D. students are encouraged to contact him for opportunities in gene regulation, development, evo-devo, and computational genomics.

Maria Hondeleمشاهده پروفایل

استادیار

• Membraneless Organelles
• Biomolecular Condensates
• Liquid-Liquid Phase Separation
• +۷ مورد دیگر

Maria Hondele is a Tenure-track Assistant Professor at the Biozentrum, University of Basel, Switzerland, where she leads a research group dedicated to understanding the formation, regulation, and function of membraneless organelles, particularly those associated with RNA processing. Her interdisciplinary work bridges biochemistry, biophysics, and cell biology to dissect how RNA-protein condensates influence gene expression. Her research focuses on liquid-liquid phase separation and the role of DEAD-box ATPases as master regulators of biomolecular condensates. She investigates how these dynamic structures control RNA flux, processing, and localization within cells. Her lab employs a multidisciplinary approach including biochemical reconstitution, biophysical measurements, high-throughput screening, and advanced imaging techniques to uncover the molecular mechanisms underlying condensate formation and function. The recent publications of her group reveal a strong thematic focus on RNA-protein interactions, phase separation, stress granules, and the enzymatic regulation of condensates by ATPases. These studies span model systems from synthetic coacervates to human cells, reflecting a comprehensive strategy to understand both fundamental principles and biological implications of membraneless organelles. ERC Starting Grant (2020) SNSF Eccellenza Professorship (2019) HFSP Long-Term Postdoctoral Fellowship (2015–2018) ETH and EMBO Postdoctoral Fellowship (2015) PhD Prize, University of Munich (2014) Boehringer Ingelheim PhD Fellowship (2008–2011) Dr. Hondele advises a vibrant team of postdoctoral fellows, PhD students, and master’s students, indicating an active and expanding research program. She has secured competitive grants and leads a productive research group contributing significantly to the field of RNA biology and cellular organization. She is also an Associate Member of the National Center of Competence in Research (NCCR) RNA & Disease, reflecting her integration into major national research initiatives. Her research group is embedded within the Biozentrum, a leading interdisciplinary research center at the University of Basel, providing access to state-of-the-art facilities and collaborative networks in molecular and cellular biology.

Lori Passmoreمشاهده پروفایل

پژوهشگر ارشد

• Molecular Biology
• Biochemistry
• Structural Biology
• +۵ مورد دیگر

Lori Passmore is a Research Fellow at the Medical Research Council Laboratory of Molecular Biology (MRC-LMB), part of the University of Cambridge's School of Clinical Medicine. Her work focuses on understanding the molecular mechanisms of multi-protein complexes involved in gene expression regulation and DNA repair. Studied pre-mRNA 3′-end processing via the Cleavage and Polyadenylation Factor (CPF) complex Investigated DNA crosslink repair through the Fanconi Anemia pathway Developed cryo-EM methodologies for structural analysis Her laboratory employs a hybrid approach combining electron cryo-microscopy , X-ray crystallography, biochemical assays, and genetic techniques to elucidate complex architectures and functional dynamics. Notable discoveries include structural insights into the FANCD2-FANCI complex and mechanisms of poly(A) tail length regulation. Current research spans topics such as: 3′-end processing coordination mRNA deadenylation pathways DNA replication stress responses Protein complex assembly principles Lori Passmore's group includes trainees and staff studying these fundamental biological processes. Their work contributes to understanding gene regulation, RNA metabolism, and DNA repair mechanisms critical for preventing diseases like cancer.

James Manleyمشاهده پروفایل

استاد

• Gene Expression Regulation
• mRNA Processing
• RNA Splicing and Polyadenylation
• +۳ مورد دیگر

James Manley is the Julian Clarence Levi Professor of the Life Sciences at Columbia University, with extensive research in gene expression regulation. His work spans transcription, RNA splicing, and polyadenylation mechanisms in human cells, connecting these processes to neurodegenerative diseases (ALS/FTD) and cancers. Affiliation: Columbia University, Department of Biological Sciences Contact: jlm2@columbia.edu Research Interests: Dr. Manley's laboratory investigates nuclear processes including: Transcriptional control via RNA polymerase II CTD modifications Alternative splicing regulation by hnRNP and SR proteins Polyadenylation dynamics in cell cycle and differentiation Disease mechanisms in spliceosome mutations (SF3B1, SRSF2) RNA-protein interactions in stress responses Publication Trends: Recent work focuses on disease-associated mutations affecting RNA processing, non-canonical RNA functions, and immune regulation via polyadenylation. Articles span molecular oncology, neurodegeneration, and RNA surveillance mechanisms. Scientific Recognition: Member, American Academy of Arts & Sciences Member, National Academy of Sciences Key Collaborations: Studies involve interdisciplinary work with neurology, cancer biology, and immunology teams. His lab employs biochemical assays, structural analysis, and genetic models to dissect RNA processing pathways.

Mikhail Gelfandمشاهده پروفایل

استاد

• molecular evolution
• comparative genomics
• systems biology
• +۷ مورد دیگر

Mikhail Gelfand is a Full Professor and Director of the Center for Molecular and Cellular Biology at Skolkovo Institute of Science and Technology (Skoltech), where he also serves as Vice President for Biomedical Research. His distinguished career spans multiple prestigious institutions including Lomonosov Moscow State University and the Higher School of Economics. His educational background includes: 1985: MSc in mathematics (functional analysis) 1993: PhD in physics-mathematics (biophysics) 1998: DSc in biology (molecular biology) 2007: full professor (bioinformatics) Professor Gelfand's research focuses on molecular evolution, comparative genomics, systems biology, and metagenomics. His work examines eukaryotic processes including alternative splicing, mRNA editing, and chromatin structure, as well as bacterial genome evolution and transcription regulation. His lab combines data on three-dimensional chromatin structure, epigenetic states, and gene expression to obtain an integrated view of genome functioning across diverse organisms from humans to amoebae. One major research direction focuses on the evolution of transcript splicing and editing, while comparative analysis of bacterial genomes yields functional annotations of novel enzymes, transporters, and transcription factors. His recent publications demonstrate a strong focus on RNA editing in cephalopods, bacterial genome analysis, and computational approaches to understanding chromatin structure. The work spans molecular biology, evolutionary biology, and bioinformatics, with particular emphasis on how RNA editing contributes to adaptation and molecular evolution across metazoans. His research shows how edited adenines are more frequently substituted with guanine in evolution than their unedited counterparts, suggesting RNA editing may enhance adaptation. His notable awards include: The President of Russian Federation's Award for Young Doctors of Science (2000) The "Best Scientist of the Russian Academy of Sciences" award (2004) A. A. Baev Prize in Genomics and Genoinformatics (2007) Member of Academia Europaea (2010) As Director of the Center for Molecular and Cellular Biology, Professor Gelfand leads a research group that combines computational and experimental approaches to study genome function and evolution. His lab's work has significant implications for understanding molecular mechanisms of evolution and adaptation across diverse biological systems, from bacteria to complex eukaryotes. His research on metagenomics extends to practical applications in areas including coral disease, aphids, and oil wells.

• Nanoelectronics
• Microsystems Packaging
• 3D Additive Manufacturing
• +۱۰ مورد دیگر

Johan Liu is a Full Professor in Electronics Production at Chalmers University of Technology, Sweden, and leads the Electronics Materials and Systems Laboratory within the Department of Microtechnology and Nanoscience. He is a member of the Royal Swedish Academy of Engineering Sciences and an IEEE Fellow, with over 500 publications and 75 patents in nanoelectronics and thermal management. Education: Master's and Ph.D. in Materials Science from the Royal Institute of Technology (KTH), Sweden His research focuses on graphene-based thermal interface materials, carbon nanotubes for 3D integration, and advanced packaging solutions. Recent work includes laser-induced graphene films, nano-soldering techniques, and biomedical nanoscaffolds. His publications span high-impact journals like Nature Communications , Advanced Materials , and IEEE Transactions , with recent trends emphasizing thermal conductivity enhancement, composite materials, and nanofluids. Johan has received prestigious awards including the IEEE Exceptional Technical Achievement Award and IEEE CPMT Best Paper Award. He has secured funding from the National Science Foundation (NSF), Swedish Board for Strategic Research (SSF), Vinnova, and EU Horizon 2020 programs. His lab specializes in scalable graphene synthesis, CNT array engineering, and reliability testing of nanomaterials in electronics.

Guillaume Chanfreauمشاهده پروفایل

استاد

• RNA metabolism
• RNA splicing
• RNA decay pathways
• +۵ مورد دیگر

Guillaume Chanfreau is a Professor in the Department of Chemistry and Biochemistry within the College of Letters and Science at the University of California Los Angeles (UCLA). His research focuses on fundamental mechanisms of RNA metabolism, with particular emphasis on RNA splicing, decay pathways, and ribonuclease functions. His work spans molecular biology, biochemistry, and genetics, utilizing yeast as a primary model organism to investigate conserved RNA processing mechanisms. Professor Chanfreau's research interests center on understanding how RNA processing pathways regulate gene expression. His work examines transcription termination, RNA splicing fidelity, RNA decay mechanisms, and the role of ribonucleases in cellular RNA homeostasis. He investigates how these processes are interconnected and how they respond to cellular stress conditions. His laboratory has made significant contributions to understanding how RNA quality control mechanisms prevent the accumulation of aberrant transcripts and maintain cellular health. Analysis of Chanfreau's recent publications (2020-2025) reveals a strong focus on RNA splicing mechanisms, RNA decay pathways, and ribonuclease functions. His work frequently employs yeast genetics combined with advanced RNA sequencing techniques. A notable trend is the increasing use of long-read sequencing technologies to analyze RNA isoforms and decay intermediates. His research consistently bridges fundamental molecular mechanisms with potential implications for understanding human diseases related to RNA processing defects. Professor Chanfreau has been continuously funded by the National Institutes of Health, with his current grant R35GM130370 (2019-2023) titled 'The Control of Gene Expression by Eukaryotic Ribonucleases' and previous long-term funding through R01GM061518 (2000-2019). His research program has supported numerous graduate students and postdoctoral researchers who have contributed to his extensive publication record spanning over two decades.

Aaron Hoskinsمشاهده پروفایل

استاد

• Pre-mRNA splicing
• Spliceosome assembly
• Single-molecule fluorescence microscopy
• +۳ مورد دیگر

Aaron Hoskins is a full-time Professor of Biochemistry and Chemistry at the University of Wisconsin–Madison, where he leads an active research program focused on pre-mRNA splicing, spliceosome assembly, and single-molecule biophysics. He is affiliated with the Department of Biochemistry and the Hoskins Group laboratory, located in the Biochemical Sciences Building. Education: B.S., 2000 – Purdue University Ph.D., 2006 – Massachusetts Institute of Technology Postdoctoral Fellow, 2006–2011 – Brandeis University and UMass Medical School His research centers on understanding the molecular mechanisms of pre-mRNA splicing and spliceosome assembly in eukaryotes. Using single-molecule fluorescence microscopy, his lab investigates how the spliceosome recognizes RNA targets, how ribonucleoproteins are assembled, and how splicing fidelity is maintained or disrupted in disease. His work integrates genetics, chemical biology, and biophysical approaches to dissect spliceosome dynamics and to develop new tools for studying RNA processing. Aaron Hoskins has published over 80 peer-reviewed articles since 2004, with recent work appearing in RNA , eLife , Structure , and Cell Chemical Biology . His research trends include the structural dynamics of spliceosomal snRNPs, cancer-associated mutations in splicing factors, and the development of splicing inhibitors as potential therapeutics. His lab also explores translational applications, including the use of humanized yeast strains for drug screening. He is supported by multiple NIH grants (R01 GM053007, R01 GM112735, R01 GM081648) and has collaborated extensively with UW-Madison colleagues David Brow and Samuel Butcher. His lab is equipped with custom-built fluorescence microscopes for single-molecule imaging and is actively training the next generation of scientists in RNA biology and biophysics.

• Biotechnology
• Systems Engineering in Bioprocessing
• Model-Based Tools
• +۴ مورد دیگر

Professor Cleo Kontoravdi is a Professor of Biological Systems Engineering at the Department of Chemical Engineering, Imperial College London, within the Faculty of Engineering. Her roles include Director of Postgraduate Studies (2021–present) and Postgraduate Admissions Tutor (2018–2021). She holds affiliations with key research centers such as the Centre for Process Systems Engineering, Centre for Synthetic Biology, and Future Vaccine Manufacturing Research Hub. Her research focuses on applying systems engineering principles to bioprocessing, integrating model-based tools like sensitivity analysis and optimization with experimental work on mammalian cell cultures and vaccine production. Key areas include metabolic flux analysis, media optimization, and multiscale modeling. Her recent publications highlight advancements in hybrid modeling frameworks, mRNA vaccine process design, and metabolic engineering of CHO cells. She actively contributes to vaccine manufacturing strategies and sustainable biopharmaceutical supply chains. Education: PhD (2007) and MEng (2002) in Chemical Engineering from Imperial College London. Professional experience spans academic roles (since 2007) and industry R&D at Lonza Biologics (2006–2007). Her work bridges computational biology, bioprocess engineering, and systems biology, addressing challenges in vaccine development and production efficiency. Awards: Not explicitly listed in the provided text. Research grants and collaborations are implied through her involvement in high-impact projects like the Future Vaccine Manufacturing Hub. She advises on bioprocess optimization, glycoengineering, and biomanufacturing sustainability.

Jörg Stülkeمشاهده پروفایل

استاد

• Microbiology
• Molecular Biology
• Systems Biology
• +۱۱ مورد دیگر

Prof. Dr. Jörg Stülke is a full Professor of Microbiology and Head of the Department of General Microbiology at the Institute of Microbiology and Genetics, University of Göttingen. He has held this position since 2003 and leads an active research group focused on bacterial metabolism and gene regulation. His research spans two major model systems: the pathogenic bacterium Mycoplasma pneumoniae and the well-studied Bacillus subtilis . His group employs systems-level approaches including transcriptomics, metabolomics, and bioinformatics to understand metabolic regulation and gene expression. Key interests include protein phosphorylation, RNA-mediated regulation, mRNA processing, and the role of second messengers such as cyclic di-AMP in bacterial physiology and pathogenicity. The recent publications reveal a strong trend in molecular microbiology, functional genomics, and systems biology. His work often integrates experimental and computational methods, particularly evident in the development and maintenance of the SubtiWiki database for B. subtilis . The research bridges fundamental mechanisms of life with applications in understanding bacterial virulence and cellular homeostasis. He is affiliated with several graduate programs under the Göttingen Graduate Center for Neurosciences, Biophysics, and Molecular Biosciences (GGNB), including: Molecular Biology (IMPRS) Biomolecules: Structure - Function - Dynamics (GZMB) Molecular Biology of Cells (GZMB) Microbiology and Biochemistry Genome Science (IMPRS) While no individual students are listed, he clearly supervises doctoral candidates through these programs. His group has secured significant research output, including publications in Science , Nucleic Acids Research , and PLOS Pathogens , indicating successful grant funding and collaborative research. The lab maintains a dedicated website at http://genmibio.uni-goettingen.de/ , which serves as a hub for research activities and resources like SubtiWiki.