معرفی
Lori Passmore is a Research Fellow at the Medical Research Council Laboratory of Molecular Biology (MRC-LMB), part of the University of Cambridge's School of Clinical Medicine. Her work focuses on understanding the molecular mechanisms of multi-protein complexes involved in gene expression regulation and DNA repair.
- Studied pre-mRNA 3′-end processing via the Cleavage and Polyadenylation Factor (CPF) complex
- Investigated DNA crosslink repair through the Fanconi Anemia pathway
- Developed cryo-EM methodologies for structural analysis
Her laboratory employs a hybrid approach combining electron cryo-microscopy, X-ray crystallography, biochemical assays, and genetic techniques to elucidate complex architectures and functional dynamics. Notable discoveries include structural insights into the FANCD2-FANCI complex and mechanisms of poly(A) tail length regulation.
Current research spans topics such as:
- 3′-end processing coordination
- mRNA deadenylation pathways
- DNA replication stress responses
- Protein complex assembly principles
Lori Passmore's group includes trainees and staff studying these fundamental biological processes. Their work contributes to understanding gene regulation, RNA metabolism, and DNA repair mechanisms critical for preventing diseases like cancer.
