Miler T. Lee

Miler T. Lee is an Associate Professor at the University of Pittsburgh, focusing on gene regulation during early embryonic development through high-throughput experimental and computational genomics. He earned his Ph.D. in Genomics and Computational Biology in 2009 from the University of Pennsylvania under Dr. Junhyong Kim, followed by postdoctoral work with Dr. Antonio Giraldez at Yale University. Joining the university in 2016, his research spans maternal-to-zygotic transition (MZT), RNA stability, pluripotency networks, and evolutionary developmental biology, utilizing model organisms like zebrafish, Xenopus, and Hydractinia symbiolongicarpus.

• Key Research Themes:
• Maternally inherited RNA dynamics during embryogenesis
• Mechanisms of RNA degradation and transcriptome remodeling
• Evolution of pluripotency networks in hybrid species
• Role of zinc signaling in fertilization barriers
• Computational tools for RNA regulation and sensing

• Scientific Awards:
• Pan-American Society for Evolutionary Developmental Biology Junior Faculty Award (2024)
• Outstanding New Investigator – International Xenopus Board (2023)
• Basil O'Connor Scholar – March of Dimes (2017-2019)

Recent publications highlight his work on enhancer classification, RNA degradation mechanisms, and cross-species MZT comparisons. His lab develops innovative methods like RESA for regulatory sequence analysis and studies evolutionary divergence in RNA localization patterns. While the articles span computational and experimental approaches, they consistently address RNA's role in cellular identity, developmental timing, and evolutionary adaptation. Applications include understanding pluripotency, designing RNA biosensors, and elucidating fertilization barriers. Prospective Ph.D. students are encouraged to contact him for opportunities in gene regulation, development, evo-devo, and computational genomics.