جستجوی استاد راهنمای دانشگاهی

Patrick Paddison is a Professor in the Human Biology Division at Fred Hutchinson Cancer Center, where he leads the Paddison Lab. His research employs cutting-edge genetic techniques, including CRISPR-Cas9 and RNAi, to investigate stem cell biology and cancer, with a particular focus on cancer stem cells in glioblastoma and the role of epigenetics and epitranscriptomics in development and disease. His educational background includes a PhD in Biological Sciences from Cold Spring Harbor Laboratory (2004) and dual bachelor's degrees in Psychology and Molecular Biology and Genetics from The Evergreen State College (1996). Dr. Paddison's research centers on functional genomics to dissect gene networks in stem and progenitor cells. His lab uses genome-wide screening to identify genes critical for stem cell self-renewal, differentiation, and survival, with applications in cancer therapy. Key areas include: Cancer stem cell biology, particularly quiescent states in glioblastoma Epigenetic and epitranscriptomic regulation (e.g., N6-adenosine methylation in erythropoiesis) Protein domain annotation via CRISPR tiling mutagenesis Developmental transitions in embryonic and somatic stem cells Analysis of his recent publications reveals a shift from RNAi-based methods to CRISPR-Cas9, with a sustained focus on cancer stem cells and the molecular mechanisms underlying developmental processes. His work increasingly integrates single-cell technologies and patient-derived models to address therapeutic resistance. Dr. Paddison mentors graduate students and postdoctoral fellows in his lab, fostering expertise in functional genomics and genome editing. While specific grant details are not provided, his extensive publication record indicates sustained funding for innovative research in cancer biology and stem cell science. The Paddison Lab is a dynamic research environment that combines high-throughput screening, molecular biology, and computational analysis to uncover fundamental biological mechanisms with translational potential in oncology.

• Cancer Stem Cells
• Functional Genomics
• Genome Editing
• +۵ مورد دیگر

Dr. Jungnam Cho is an Associate Professor in the Department of Biosciences at Durham University. Previously, he served as a group leader at the CAS-JIC Centre of Excellence for Plant and Microbial Sciences (2018–2023) after completing postdoctoral research at the University of Cambridge (2013–2018). He holds a BSc (2007) and PhD (2013) from Seoul National University. His research focuses on transposable elements ("jumping genes") in plants, exploring their roles in genome evolution, epigenetic regulation, and crop improvement. Using Arabidopsis and rice as models, his lab combines molecular biology, biochemistry, and computational tools to dissect transposon mobilization mechanisms. Key areas include RNA methylation, genome plasticity, and epitranscriptomics. Recent grants include a BBSRC standard research grant (2025) and funding from the Great Britain Sasakawa Foundation (2024). He supervises PhD students Ben Shone and Seunghui Mun, with additional training roles for interns and undergraduates. Collaborations extend to institutions like Zhejiang University and Fudan University. Lab activities emphasize translational applications, such as enhancing crop genetic diversity and addressing global food security through epigenetic insights. Current projects include studies on bamboo epigenetic reprogramming and heat-activated retrotransposons in Arabidopsis.

• Transposable Elements
• Genome Plasticity
• Epigenetics
• +۳ مورد دیگر

Erik Dassi is an Associate Professor at the Department of Cellular, Computational and Integrative Biology (CIBIO) within the University of Trento. His research focuses on RNA biology, particularly investigating RNA structure-functional relationships, translational control mechanisms, and their implications in cancer, neurodegenerative diseases, and genetic disorders. He specializes in exploring how RNA modifications, G-quadruplex structures, and post-transcriptional regulatory networks drive disease processes and therapeutic resistance. Teaching activities include courses on Computational Biology, Cancer Genomics, Genomics Technologies, Programming, and Scientific Programming. His work emphasizes integrative approaches combining experimental and computational methods, such as polysomal profiling, allele-specific proteomics, and single-cell transcriptomics. Key research themes include: RNA G-quadruplex regulation of mitochondrial translation and energy metabolism ( n =3 articles in 2025), YTHDF proteins as tumor drivers in m6A pathways ( n =2 articles in 2024), and circular RNA roles in Huntington’s disease ( n =4 articles across 2021-2024). His work highlights translational reprogramming in cancer therapy resistance and RNA-based biomarker discovery.

• Ribonucleic acid (RNA)
• Data Analysis
• Bioinformatics
• +۱۲ مورد دیگر

Masad J. Damha is a Distinguished James McGill Professor in the Department of Chemistry at McGill University. He holds a B.Sc. (1983) and Ph.D. (1988) from McGill University and completed postdoctoral training at the California Institute of Technology. His research bridges chemical biology and synthesis/catalysis, focusing on the chemical synthesis, biochemical properties, and molecular behavior of nucleosides, nucleic acids, and their analogues, with applications in biotechnology including siRNA, antisense oligonucleotides, and aptamers. Research Interests: Professor Damha's work explores inter- and intracellular communication between nucleic acids and proteins, particularly investigating how chemically modified nucleic acids (e.g., ANA, 2’F-ANA) can enhance therapeutic efficacy. His research aims to develop novel strategies for genetic regulation and diagnostic tools through engineered nucleic acid systems. Honors and Awards: R.U. Lemieux Award (CIC, 2020) Queen Elizabeth II Diamond Jubilee Medal (2012) Bernard Belleau Award (CSC/CIC, 2007) Merck-Frosst Award for Therapeutic Research (1999) Fellow of the Chemical Institute of Canada (FCIC, 1999) John Charles Polanyi Chemistry Prize (1989) Leo Yaffe Award for Excellence in Teaching (2011-12) David Thomson Award in Graduate & Teaching (2010) Teaching and Leadership: Professor Damha teaches Introductory Organic Chemistry (CHEM 302) and Advanced Nucleic Acid Chemistry (CHEM 542). He has held leadership roles as President of the International Society of Nucleosides, Nucleotides & Nucleic Acids (2019-20) and the Oligonucleotide Therapeutics Society (2013-14).

• Chemical Biology
• Nucleic Acid Chemistry
• Biotechnology
• +۲ مورد دیگر

Jeff Coller is the Bloomberg Distinguished Professor of RNA Biology and Therapeutics at Johns Hopkins University. His primary affiliation is with the Whiting School of Engineering and the Johns Hopkins School of Medicine, within the Department of Biomedical Engineering. He holds a PhD in Cellular and Molecular Biology from the University of Wisconsin and completed postdoctoral training at the Howard Hughes Medical Institute, University of Arizona. Previously, he was Director of the RNA Center at Case Western Reserve University and held the Henry Willson Payne Distinguished Professorship. Research Focus: Coller's lab investigates mRNA stability and translation, particularly how mRNA sequence features like codon optimality influence gene expression. His work bridges fundamental biology and translational medicine, with a focus on RNA-based therapies. He co-founded Tevard Biosciences and WyveRNA Therapeutics, which focus on RNA therapeutics. His research has been cited over 6,000 times and led to several patents in RNA-based therapies. Education: PhD in Cellular and Molecular Biology, University of Wisconsin; Postdoc at HHMI, University of Arizona Labs/Teams: Coller Lab (Johns Hopkins University) Grants/Funding: Not explicitly detailed, but implied via patent activity and industry partnerships Key Contributions: Demonstrated that mRNA sequence features directly influence stability and translation efficiency. Pioneered understanding of codon optimality's role in mRNA fate. Co-developed novel RNA-based therapeutics.

• mRNA stability
• translation elongation
• RNA therapeutics
• +۳ مورد دیگر

Zenghuo Lin is an Associate Professor in the Department of Biology at Saint Louis University, part of the College of Arts and Sciences. His research focuses on the evolution of genomes and gene regulation in fungal models. Lin holds a Ph.D. from Pennsylvania State University. His lab, the Lin Lab (www.zlinlab.org), develops bioinformatics tools like TSSr for analyzing transcription start site (TSS) data. Key research themes include transcription initiation mechanisms, genome divergence post-hybridization, and functional impacts of 5'UTR length evolution. Notable recent work includes studies on ribosomal subunit modulation in cancer progression, yeast poly(A)-binding proteins, and the genomic origins of cultivated bananas. Lin collaborates widely, with funding from sources like the National Institutes of Health and NSF, and mentors over 30 graduate and undergraduate students. He teaches courses in genetics, genomics, and bioinformatics. Publications span high-impact journals like Genome Research, Nature Genetics, and Nature Protocols. Awards include recognition for contributions to fungal genomics. Lin advises on genomic projects ranging from Saccharomyces bayanus assembly to desert-adapted Drosophila genetics. His lab actively pursues systems-level approaches to RNA epitranscriptomics and epigenetic regulation, with future directions in synthetic biology applications of transcriptional control mechanisms.

• Genomics
• Evolutionary Biology
• Molecular Biology
• +۵ مورد دیگر

Pavlina Gregorova is a Doctoral Researcher at the University of Helsinki , affiliated with the Faculty of Biological and Environmental Sciences and the Molecular and Integrative Biosciences Research Programme . Her work bridges biochemistry, molecular biology, and microbiology. Biochemistry, cell and molecular biology Biomedicine Microbiology and virology Research Interests focus on post-transcriptional RNA modifications, particularly their role in translation regulation and infection dynamics. Recent studies explore tRNA cleavage in extremophiles, RNA modifications in prostate cancer, and aging-related protein structural changes. Scientific Contributions include developing novel methods for RNA virus quantification, analyzing RNA modification landscapes, and characterizing enzyme-polymerization-based longevity controls. Her work spans Microorganisms , Nucleic Acids Research , and Molecular Cell . Fulbright Finland Foundation Travel Grant for Research Collaboration (2020) She actively supervises Master's theses and participates in international collaborations, including a research visit at Johns Hopkins University . Gregorova contributes to organizations like the RNA Society and Societas biochemica, biophysica et microbiologica Fenniae .

• Biochemistry, cell and molecular biology
• Biomedicine
• Microbiology and virology

Shim Jae-kyung serves as Assistant Professor in the Department of Bioindustry and Resource Engineering at Sejong University's School of Life Systems, where she has conducted research since 2015 following her prior appointment in the Department of Molecular Biology (2003-2014). Her work centers on nuclear signaling mechanisms and disease pathogenesis. Her academic foundation includes: Ph.D. in Biological Science from Korea Advanced Institute of Science and Technology (2000) M.S. in Biochemistry from Yonsei University (1994) B.S. in Biochemistry from Yonsei University (1991) Research focuses on nuclear signal transduction and gene expression regulation , particularly examining Notch/STAT3 pathway crosstalk , nuclear membrane protein functions (Emerin), and RNA modification mechanisms (YTHDF2). Her laboratory employs zebrafish developmental models , mammalian cell systems , and plant stress response studies to investigate disease mechanisms including cancer progression and developmental disorders. Current work reveals how spatial control of signaling molecules at the nuclear membrane regulates transcriptional outcomes. Publication analysis shows consistent emphasis on nuclear signaling hubs since 2014, with recent work (2021-2024) demonstrating triptolide's dual regulation of Notch/STAT3 in cancer and development, Emerin's spatial control of STAT3, and YTHDF2's post-transcriptional regulation of Notch. Plant research complements this through stress response mechanisms in crops. Professor Shim leads the Molecular and Cellular Biology Laboratory (Chung1127), supervising master's thesis research while teaching courses including General Biochemistry, Biopolymer Engineering, and Antibody Engineering. Her consultation hours are Monday, Wednesday, and Friday 3:00-5:00 PM.

• Molecular Cell Biology
• Signal Transduction
• Gene Expression Regulation
• +۵ مورد دیگر

Dr. Mridusmita Saikia is a Lecturer at the Meinig School of Biomedical Engineering, Cornell University, since 2020. Her research focuses on biomedical engineering, biomolecular engineering, and molecular and cellular engineering, with expertise in RNA modifications, diabetes pathogenesis, and single-cell RNA sequencing. She teaches courses in Cellular and Molecular Engineering, emphasizing foundational concepts applicable to biomedical innovations. Education includes a B.Sc. (Chemistry, St. Stephen’s College, University of Delhi, 2002), M.Sc. (Chemistry, IIT Delhi, 2004), M.S. (Chemistry, University of Chicago, 2005), and Ph.D. (Chemistry, University of Chicago, 2009). Postdoctoral research was conducted at Case Western Reserve University and Cornell University. Her research explores non-coding RNAs and their roles in gene expression, with recent work on immune cell function and pancreatic beta-cell pathology linked to diabetes. She employs single-cell sequencing and molecular engineering techniques to advance understanding of cellular mechanisms in health and disease. Awards: Robert & Vanne Cowie Teaching Award (2022), CRISTEL Award (2022–2023), Prodo Labs Best Talk Award (2020), and multiple fellowships including the Burroughs Wellcome Fellowship (2005–2006). Teaching includes courses like BME 2010 (Physiology of Health/Disease), BME 3010 (Cellular Principles), and BME 5830 (Cell-Biomaterial Interactions). Her pedagogy aims to bridge foundational concepts with clinical and engineering applications. Research outputs span diabetes mechanisms, RNA stress responses, and single-cell profiling. Collaborations include studies on GLP-1 receptor signaling, beta-cell differentiation, and tiRNA functions in apoptosis.

• Biomedical Engineering
• Molecular Biology
• Genomics
• +۳ مورد دیگر

Huiqing (Jane) Zhou is an Assistant Professor of Chemistry at Boston College, affiliated with the Morrissey College of Arts and Sciences and the Chemistry Department. Her research focuses on developing technologies to map and modulate RNA chemical modifications (epitranscriptome) in mammalian systems. She employs interdisciplinary approaches including directed evolution, biochemistry, mass spectrometry, and structural biology to study the regulatory mechanisms of these modifications in gene expression and disease. Education: B.S., Nankai University Ph.D., Duke University Research Interests: Her lab explores how RNA modifications influence transcript stability, interactions, and expression, with applications in disease modeling and gene therapy. Key areas include base-resolution mapping of modifications, engineering tools for modification manipulation, and understanding dysregulated epitranscriptomes in diseases like Alzheimer’s. Publications: Her work spans publications in Nature Methods , Biochemistry , and Nucleic Acids Research , focusing on reverse transcriptase evolution, Hoogsteen base pairing dynamics, and RNA modification detection technologies. Awards: 2017 Chicago Fellows Fellowship. Lab & Funding: Supported by Boston College and grants from the National Institutes of Health (NIGMS, NCI). Her lab develops cutting-edge tools to visualize and modulate RNA modifications, aiming to identify novel drug targets and advance gene therapy strategies.

• Epitranscriptomics
• RNA Modifications
• Nucleic Acid Chemistry
• +۴ مورد دیگر

Amanda Garner is a Professor in the Department of Medicinal Chemistry at the University of Michigan , focusing on RNA biology and cancer therapeutics. Her work centers on targeting RNA-binding proteins (RBPs) and translation regulation mechanisms, particularly eIF4E, which plays a critical role in oncogenic protein synthesis. Research Themes: eIF4E inhibition, RNA-protein interactions, mRNA cap analogs, and translational control in cancer. Collaborations: Active partnerships with researchers like Emilio L Cárdenas, Jeanne Stuckey, and Vibha Lama. Recent studies explore CRISPR-based screening for RNA-protein interactions, second-generation prodrugs for cancer therapy, and neuroprotective roles of αA-crystallin. She also contributes to diversity initiatives in medicinal chemistry through the ACS Division.

• Medicinal Chemistry
• RNA Biology
• Cancer Therapeutics
• +۳ مورد دیگر

Kathy Fange Liu, Ph.D., is an Associate Professor with tenure at the University of Pennsylvania Perelman School of Medicine. She serves as Co-Director of the Penn Center for Genome Integrity and Group Lead at the Penn Institute for RNA Innovation. The lab combines deep mechanistic studies with innovative therapeutic development across four major research directions: X-Y paired homologous proteins, cancer fusion proteins, ribosome biology, and cross-RNA modification coregulation. Research highlights include pioneering the concept of RNA modification coregulation (DOI:10.1073/pnas.1913448117), where enzyme-mediated modifications across RNA species demonstrate interconnected networks. Current projects investigate rRNA-modifying enzymes' dual roles in ribosome assembly and genome organization, while developing targeted therapies for fusion oncoproteins like TRIM24-ERG (US patent 63/797,545). 2025 Damon Runyon-Rachleff Innovator Award Stage 2 2024 St. Baldrick's Research Grant 2023 Linda Pechenik Montague Investigator 2022 Damon Runyon & ACS Scholar awards 2019 NIH MIRA R35 award Lab members include 6 postdocs (Praneeth Bommisetti, Yanze Jian, Sarai Mendoza, Yulia Gonskikh, Hyojeong Hwang, Sheetal Tushir) and 3 graduate trainees. Former lab members Hui Shen (now professor at China Pharmaceutical University), Julian Stoute (Ph.D. 2023), and Jordan Ontiveros (Ph.D. 2022) received multiple fellowships during their tenure. Key grants include NIH/NHLBI R01 (2022), CZI Multi-Institutional Collaboration (2024), and continuous support from private foundations like CURE Childhood Cancer and Alex's Lemonade Stand. The lab actively develops technologies for RNA modification analysis while maintaining strong collaborative ties across Penn's epigenetics and structural biology programs.

• RNA Biochemistry
• Cancer Biology
• Epitranscriptomics
• +۳ مورد دیگر

Yuru Wang is an Assistant Professor of Medicinal Chemistry at the University of Utah , College of Pharmacy. She is affiliated with both the Molecular Biology Program and the Biological Chemistry Program , where she leads the Wang Lab focused on epitranscriptomics and RNA therapeutics . Education: B.S., Nankai University Ph.D., University of California, Davis Research Interests: Dr. Wang's research centers on understanding RNA modifications such as pseudouridine and inosine , and their roles in cellular processes like immune responses, phase separation, and embryonic development. Her lab develops innovative molecular tools and therapeutic strategies targeting RNA modifications. Her work spans multiple disciplines including biochemistry , RNA biology , mass spectrometry , protein engineering , and genetics . Publications & Trends: Dr. Wang's recent publications (2023-2015) demonstrate a strong focus on pseudouridine detection and RNA modification mapping , particularly using advanced sequencing techniques like LEAD-m6A-seq and BID-seq . Her work also emphasizes enzyme engineering for RNA modification tools and ADAR enzyme specificity . Lab & Training: The Wang Lab provides an interdisciplinary training environment for graduate students and postdocs, preparing them for careers in RNA biology and therapeutics. The lab's ultimate goal is to develop innovative RNA-based therapies and identify new drug targets for human diseases.

• Epitranscriptomics
• RNA Modifications
• Pseudouridine
• +۵ مورد دیگر

Xinshu Xiao is a Professor in the Department of Integrative Biology and Physiology at the University of California Los Angeles, within the College of Letters and Science. She leads an active research laboratory focused on RNA biology and computational genomics, with significant contributions to understanding RNA editing, alternative splicing, and their roles in neurological disorders and cancer. Dr. Xiao earned her PhD in Health Sciences and Technology from the Massachusetts Institute of Technology in 2004. Her research career has been marked by continuous NIH funding and innovative methodological developments in transcriptome analysis. Her primary research interests center on RNA editing mechanisms, particularly A-to-I editing, and their implications in neurological disorders like schizophrenia and Alzheimer's disease, as well as cancer. She has developed several important computational tools for RNA analysis, including RASER, L-GIREMI, and dsRID. Her work bridges computational biology with molecular mechanisms, employing long-read RNA sequencing technologies to uncover novel aspects of RNA processing. Analysis of her recent publications reveals a strong focus on the intersection of RNA biology with neurological disorders, particularly schizophrenia and Alzheimer's disease, alongside significant work in cancer genomics. Her research increasingly incorporates long-read sequencing technologies to resolve complex aspects of RNA processing that were previously inaccessible with short-read approaches. Dr. Xiao currently serves as Principal Investigator on multiple NIH grants, including R01AG078950, R01CA262686, R01AG075206, and R01MH123177, demonstrating sustained funding success across multiple research domains. Her laboratory, the Xiao Lab, maintains active collaborations across multiple disciplines and institutions, as evidenced by her extensive publication record with diverse co-authors spanning computational biology, neuroscience, and cancer research fields.

• RNA Editing
• Alternative Splicing
• Transcriptomics
• +۷ مورد دیگر

Mingming Lu is a Research Fellow in the Department of Neurology at Yale University's Yale School of Medicine. Their work focuses on genomic and transcriptomic research, with a particular emphasis on bioinformatics, disease associations, and aging biology. Current research includes developing databases for genomic analysis and exploring epigenetic mechanisms in health and disease. Research interests span endogenous retroviruses, transcriptome-wide association studies (TWAS), and the role of m6A RNA modifications in aging. Lu has contributed to initiatives like the HervD Atlas and TWAS Atlas, which aim to curate genomic data for disease research. Their work also involves cancer genomics, including tumor variant identification and single-cell expression mapping in cancer. No scientific awards are listed. Advising no formal trainees is recorded, though their research collaborations may involve team-based projects. Lu is affiliated with the National Genomics Data Center in China and contributes to genomic database development, reflecting their role in bridging computational methods with biological discovery.

• Genomics
• Transcriptomics
• Bioinformatics
• +۶ مورد دیگر