Shim Jae-kyung

Shim Jae-kyung serves as Assistant Professor in the Department of Bioindustry and Resource Engineering at Sejong University's School of Life Systems, where she has conducted research since 2015 following her prior appointment in the Department of Molecular Biology (2003-2014). Her work centers on nuclear signaling mechanisms and disease pathogenesis.

Her academic foundation includes:

• Ph.D. in Biological Science from Korea Advanced Institute of Science and Technology (2000)
• M.S. in Biochemistry from Yonsei University (1994)
• B.S. in Biochemistry from Yonsei University (1991)

Research focuses on nuclear signal transduction and gene expression regulation, particularly examining Notch/STAT3 pathway crosstalk, nuclear membrane protein functions (Emerin), and RNA modification mechanisms (YTHDF2). Her laboratory employs zebrafish developmental models, mammalian cell systems, and plant stress response studies to investigate disease mechanisms including cancer progression and developmental disorders. Current work reveals how spatial control of signaling molecules at the nuclear membrane regulates transcriptional outcomes.

Publication analysis shows consistent emphasis on nuclear signaling hubs since 2014, with recent work (2021-2024) demonstrating triptolide's dual regulation of Notch/STAT3 in cancer and development, Emerin's spatial control of STAT3, and YTHDF2's post-transcriptional regulation of Notch. Plant research complements this through stress response mechanisms in crops.

Professor Shim leads the Molecular and Cellular Biology Laboratory (Chung1127), supervising master's thesis research while teaching courses including General Biochemistry, Biopolymer Engineering, and Antibody Engineering. Her consultation hours are Monday, Wednesday, and Friday 3:00-5:00 PM.