جست‌وجوی استاد و پژوهشگر

Ade Whitehouseمشاهده پروفایل

استاد

• Molecular Virology
• RNA Biology
• Epitranscriptomics
• +۱۰ مورد دیگر

Professor Ade Whitehouse is a leading researcher in molecular virology at the University of Leeds, Faculty of Biological Sciences, within the School of Molecular and Cellular Biology. His research focuses on understanding how oncogenic viruses such as Kaposi's sarcoma-associated herpesvirus (KSHV) and Merkel cell polyomavirus (MCPyV) hijack host cell machinery to replicate and drive carcinogenesis. His research interests include: Role of RNA modifications (especially m6A methylation) in viral infection Virus-induced specialized ribosomes and translational control Manipulation of non-coding RNA (ncRNA) regulatory networks by viruses Development of novel antiviral strategies through structural-based rational drug design His lab employs cutting-edge transcriptomic and quantitative proteomic approaches to identify critical virus-host interactions as targets for therapeutic intervention. Although vaccines for some oncogenic viruses exist, none are available for KSHV and MCPyV, making his work on novel antiviral compounds particularly significant. The trends in his research—spanning RNA biology, epitranscriptomics, and translational regulation—reflect a strong interdisciplinary focus on molecular mechanisms of viral pathogenesis and innovative therapeutic development. He has not listed any scientific awards in the provided text. Professor Whitehouse advises research students and leads a dynamic research group, though specific names of students are not mentioned. His team utilizes virtual high-throughput screening and molecular modeling to design small-molecule inhibitors targeting essential virus-host interactions. Grants or funding sources are not specified, but the scope of his research implies substantial external support. The Whitehouse laboratory is actively involved in elucidating complex regulatory networks involving RNA modifications and ribosome specialization during viral infection, positioning it at the forefront of molecular virology and RNA-based disease mechanisms.

• Functional genomics
• tRNA biology
• Microbiome
• +۴ مورد دیگر

Professor Tao Pan is a leading researcher in RNA biology at the University of Chicago's Department of Biochemistry and Molecular Biology. His laboratory pioneers methodologies for studying tRNA dynamics, epitranscriptomics, and microbiome-host interactions through innovative sequencing technologies. His research spans three interconnected domains: tRNA biology : Developing high-throughput sequencing to measure tRNA abundance, charging, and modifications, revealing roles in translational control and extratranslational functions Microbiome characterization : Creating tRNA-seq as an RNA-based alternative to 16S/shotgun metagenomics to capture dynamic microbiome activity Epitranscriptomics : Investigating mRNA modifications like m6A in gene regulation, discovering the 'm6A switch' mechanism affecting RNA structure and protein binding His publication trends demonstrate consistent innovation in RNA modification mapping techniques, with recent work focusing on nanopore sequencing applications, microbiome-induced epitranscriptomic reprogramming, and therapeutic mRNA engineering. Key recurring themes include tRNA modification dynamics, host-microbiome crosstalk, and RNA modification detection methodologies. Scientific recognition includes: NIH Director's Pioneer Award (2011-2016) NIH EUREKA Award (2009-2013) AAAS Fellow (2015) Multiple early-career cancer research awards His laboratory maintains substantial NIH funding through multiple R01 grants (current awards totaling >$5M annually), focusing on tRNA sequencing applications in cancer (R33CA272357), microbiome-host interactions (R21AI169280), and snoRNA functions (R01HG012780). The Pan Lab has established tRNA-seq as a novel microbiome characterization platform and pioneered discoveries in m6A-mediated RNA structural switching. Research infrastructure includes development of specialized sequencing technologies for simultaneous tRNA modification and fragmentation analysis, with recent expansion into nanopore-based direct RNA modification detection. Current work explores therapeutic applications of tRNA modification knowledge in cancer and infectious disease contexts.

• Genomics
• Epigenetics
• Systems Biology
• +۷ مورد دیگر

Gary Hon is an Assistant Professor at the University of Texas Southwestern Medical Center (UTSW), jointly affiliated with the Cecil H. and Ida Green Center for Reproductive Biology Sciences and the Lyda Hill Department of Bioinformatics. His research lies at the intersection of genomics, epigenetics, and systems biology, with a focus on decoding the regulatory complexity of the human genome. His research interests include: Understanding the molecular basis of cell state for applications in regenerative medicine Elucidating how non-coding genetic variants contribute to development and disease Developing integrative techniques combining gene regulation, epigenetics, genome engineering, and single-cell genomics Advancing bioinformatics tools for analyzing chromatin and transcriptional regulation The trends across his recent publications reveal a strong emphasis on enhancer biology, epigenetic modifications (especially 5mC and 5hmC), single-cell functional genomics, and the development of novel molecular tools such as in situ chromatin capture and combinatorial perturbation assays. His work frequently leverages CRISPR-based technologies and high-throughput sequencing to dissect gene regulatory networks. Dr. Hon has received significant recognition for his innovative research, including: CPRIT Scholar NIH Director’s New Innovator Award Dr. Hon leads the Hon Lab, which actively develops and applies systems-level approaches to study genome regulation. His collaborative research involves advising graduate students and postdoctoral fellows, many of whom appear as co-authors on his publications. While specific grant details are not listed, his prestigious awards suggest substantial federal and state funding support for his high-impact, interdisciplinary research program.

Andrew Macdonaldمشاهده پروفایل

استاد

• Oncogenic viruses
• cell biology
• virology
• +۱ مورد دیگر

Professor Andrew Macdonald is a leading expert in tumour virology at the University of Leeds, holding the position of Professor of Tumour Virology in the School of Molecular and Cellular Biology and serving as Pro-Dean for Research and Innovation in the Faculty of Biological Sciences. His work focuses on understanding how DNA tumour viruses, such as human papillomaviruses (HPV) and polyomaviruses, contribute to cancer and identifying novel therapeutic strategies. He has held roles including Head of the School of Molecular and Cellular Biology (2020–2023) and has been recognized for his research on viral mechanisms and their clinical implications. Education: BSc, University of Leeds PhD in Molecular Biology, University of Leeds (2001) Research Interests: His research integrates virology, oncology, and cell biology to study viral replication, host-pathogen interactions, and antiviral therapies. Key areas include HPV-induced cervical cancer, BK polyomavirus in kidney disease, and the role of cellular signaling pathways in viral persistence. His lab emphasizes interdisciplinary collaboration with clinicians and industry to translate findings into clinical applications. Funding & Grants: Recent funding highlights include a boost for radiotherapy research in Leeds (2024) and studies on BK nephropathy in transplantation (2023). His work has been featured in outlets like the BBC and Yorkshire Post. Labs & Teams: He leads the Macdonald Lab, a well-funded group with state-of-the-art molecular and cellular facilities. The lab fosters a supportive environment for staff and students, emphasizing career development and publication.

Paul Marshallمشاهده پروفایل

پژوهشگر

• Neuroscience
• Epigenetics
• RNA Biology
• +۳ مورد دیگر

Dr. Paul Marshall is a Researcher at the Queensland Brain Institute, The University of Queensland, supported by an NSERC Scholarship. His work focuses on neuroepigenetic mechanisms underlying learning and memory, with expertise in RNA biology, DNA structure dynamics, and fear extinction processes. He completed his PhD in 2020 at the Queensland Brain Institute, exploring dynamic DNA structure states and their role in memory. His research integrates cutting-edge technologies to study noncoding RNAs, epigenetic modifications (e.g., m6A, Z-DNA), and their impact on synaptic plasticity and cognitive functions. Key contributions include identifying the role of DNA G-quadruplex in transcriptional control, the function of long noncoding RNAs in fear extinction, and mechanisms linking RNA editing (via ADAR1) to memory consolidation. His findings bridge molecular biology with behavioral neuroscience, advancing understanding of how genetic and epigenetic factors influence cognitive processes. Publications highlight collaborations with Timothy Bredy and others, emphasizing interdisciplinary approaches to unravel neural mechanisms. No awards are explicitly listed, but his work is recognized in high-impact journals like Nature Neuroscience and Cell Reports .

Sebastian Baumgartenمشاهده پروفایل

پژوهشگر

• RNA modifications
• Parasitology
• Malaria
• +۱۲ مورد دیگر

Sebastian Baumgarten is the Head of the 'Parasite RNA Biology' Group at the Institut Pasteur, France, a position he has held since June 2021. He is affiliated with the Department of Biology of Host-Parasite Interactions. Previously, he was a post-doctoral researcher at the same institute from 2016 to 2021. His educational background includes a Ph.D. (2013–2016) and MSc (2012–2013) from the Red Sea Research Center at King Abdullah University of Science and Technology, Saudi Arabia, and a BSc (2009–2012) from the University of Tübingen, Germany. His research centers on RNA biology in malaria parasites, particularly focusing on RNA modifications such as m6A and tRNA methylation, epigenetic regulation, and post-transcriptional gene control in Plasmodium falciparum . He employs advanced genomic techniques including CRISPR, RNAseq, and ChIPseq to study gene regulation and immune evasion mechanisms in protozoan parasites. His recent publications reveal a strong trend in understanding how RNA modifications influence parasite development, stress response, and antigenic variation. His work bridges molecular parasitology with epitranscriptomics, contributing significantly to the understanding of gene regulation in malaria parasites. Notable scientific contributions include studies published in Nature Microbiology , mBio , EMBO Reports , and Life Science Alliance , focusing on m6A methylation, RUF6 ncRNA interactions, and cohesin-mediated gene repression. He has supervised or collaborated with several researchers including post-doctoral fellows, PhD students, and technicians within his team. His group is actively involved in uncovering the molecular mechanisms of parasite survival and immune evasion, with potential implications for antimalarial drug and vaccine development. The 'Parasite RNA Biology' group operates within the Institut Pasteur's ecosystem, leveraging interdisciplinary platforms for genomics, imaging, and functional analysis to advance understanding of malaria parasite biology.

• Genomic Evolution
• Tumor Metabolism
• Transcriptional Regulatory Mechanisms
• +۳ مورد دیگر

Dan HUANG is an Assistant Professor in the Department of Basic Immunology and Microbiology at the School of Life Sciences, Southern University of Science and Technology. He obtained his Ph.D. in Chemical Pathology from The Chinese University of Hong Kong (2014-2018) and a Bachelor's degree in Bioinformatics from Harbin Medical University (2008-2013). His professional journey includes postdoctoral research at SUSTech (2021-2023) and The Chinese University of Hong Kong (2019-2020), plus a Chief Scientist role at Cytomics Limited (2020-2021). Research Interests: Genomic Evolution Tumor Metabolism Transcriptional Regulatory Mechanisms Publication Trends (2020-2023): His work focuses on leveraging multi-omics data to uncover mechanisms in cancer resistance, including RNA methylation (m6A), microbiome interactions, and evolutionary adaptations of tumor suppressor genes. Key themes include immunotherapy optimization, epigenetic regulation, and cross-disciplinary applications of bioinformatics to clinical and environmental contexts. Academic Background: Ph.D., Chemical Pathology, The Chinese University of Hong Kong (2014-2018) Bachelor's, Bioinformatics, Harbin Medical University (2008-2013)

Patrick Paddisonمشاهده پروفایل

استاد

• Cancer Stem Cells
• Functional Genomics
• Genome Editing
• +۵ مورد دیگر

Patrick Paddison is a Professor in the Human Biology Division at Fred Hutchinson Cancer Center, where he leads the Paddison Lab. His research employs cutting-edge genetic techniques, including CRISPR-Cas9 and RNAi, to investigate stem cell biology and cancer, with a particular focus on cancer stem cells in glioblastoma and the role of epigenetics and epitranscriptomics in development and disease. His educational background includes a PhD in Biological Sciences from Cold Spring Harbor Laboratory (2004) and dual bachelor's degrees in Psychology and Molecular Biology and Genetics from The Evergreen State College (1996). Dr. Paddison's research centers on functional genomics to dissect gene networks in stem and progenitor cells. His lab uses genome-wide screening to identify genes critical for stem cell self-renewal, differentiation, and survival, with applications in cancer therapy. Key areas include: Cancer stem cell biology, particularly quiescent states in glioblastoma Epigenetic and epitranscriptomic regulation (e.g., N6-adenosine methylation in erythropoiesis) Protein domain annotation via CRISPR tiling mutagenesis Developmental transitions in embryonic and somatic stem cells Analysis of his recent publications reveals a shift from RNAi-based methods to CRISPR-Cas9, with a sustained focus on cancer stem cells and the molecular mechanisms underlying developmental processes. His work increasingly integrates single-cell technologies and patient-derived models to address therapeutic resistance. Dr. Paddison mentors graduate students and postdoctoral fellows in his lab, fostering expertise in functional genomics and genome editing. While specific grant details are not provided, his extensive publication record indicates sustained funding for innovative research in cancer biology and stem cell science. The Paddison Lab is a dynamic research environment that combines high-throughput screening, molecular biology, and computational analysis to uncover fundamental biological mechanisms with translational potential in oncology.

Stacy M. Hornerمشاهده پروفایل

دانشیار

• RNA Biology
• Cell Biology
• Antiviral Innate Immunity
• +۳ مورد دیگر

Stacy M. Horner is an Associate Professor in the Department of Integrative Immunobiology at Duke University School of Medicine. Her research focuses on the intersection of RNA biology, cell biology, and immunology within the context of Flaviviridae virus infections, including dengue, Zika, and hepatitis C viruses. She holds multiple academic appointments across Duke's Basic Science Departments and is affiliated with the Duke Cancer Institute and Duke Initiative for Science & Society. Her research interests center on understanding how RNA modifications regulate virus-host interactions, particularly through mechanisms involving m6A methylation and UFMylation pathways . Her work explores both viral replication strategies and host antiviral innate immune responses. Recent publications highlight her contributions to mapping post-translational modifications in orthoflaviviruses, with specific focus areas including RNA regulatory controls, mitochondrial antiviral signaling, and interferon response modulation. Her work appears in journals such as J Virol , Nat Biotechnol , and Cell Host Microbe . Horner has secured significant research grants from the National Institute of Allergy and Infectious Diseases and other NIH divisions for projects investigating RNA modifications and intestinal immune regulation.

• Ribonucleic acid (RNA)
• Data Analysis
• Bioinformatics
• +۱۲ مورد دیگر

Erik Dassi is an Associate Professor at the Department of Cellular, Computational and Integrative Biology (CIBIO) within the University of Trento. His research focuses on RNA biology, particularly investigating RNA structure-functional relationships, translational control mechanisms, and their implications in cancer, neurodegenerative diseases, and genetic disorders. He specializes in exploring how RNA modifications, G-quadruplex structures, and post-transcriptional regulatory networks drive disease processes and therapeutic resistance. Teaching activities include courses on Computational Biology, Cancer Genomics, Genomics Technologies, Programming, and Scientific Programming. His work emphasizes integrative approaches combining experimental and computational methods, such as polysomal profiling, allele-specific proteomics, and single-cell transcriptomics. Key research themes include: RNA G-quadruplex regulation of mitochondrial translation and energy metabolism ( n =3 articles in 2025), YTHDF proteins as tumor drivers in m6A pathways ( n =2 articles in 2024), and circular RNA roles in Huntington’s disease ( n =4 articles across 2021-2024). His work highlights translational reprogramming in cancer therapy resistance and RNA-based biomarker discovery.

Anumantha Kanthasamyمشاهده پروفایل

عضو هیئت علمی

• Neurodegenerative Diseases
• Parkinson's Disease (PD)
• Neurotoxicology
• +۷ مورد دیگر

Anumantha Kanthasamy is the Johnny Isakson Distinguished Professor and Director of the Isakson Center for Neurological Disease Research at the University of Georgia's College of Veterinary Medicine. He holds the Georgia Research Alliance Eminent Scholar title and leads a lab focused on neurodegenerative diseases, particularly Parkinson’s Disease (PD). His research integrates molecular mechanisms of neurotoxicity, protein aggregation, mitochondrial dysfunction, and translational biomarker development. Affiliations: Department of Physiology and Pharmacology, Isakson Center for Neurological Disease Research, University of Georgia Education: PhD in Biochemistry (University of Madras), Postdoctoral training in Pharmacology at Purdue University Research Interests include: neurotoxicant-induced dopaminergic degeneration, α-synuclein aggregation pathways, mitochondrial dysfunction in neurodegeneration, and development of biomarkers and therapies targeting PD. His work bridges basic science and clinical translation, including live-bacterial L-DOPA therapy and exosome-based diagnostics. Key Contributions include identifying PKCδ as a key mediator of oxidative stress-induced neuronal death, discovering manganese’s role in protein aggregation via prion protein interactions, and pioneering RT-QuIC-based detection of α-synuclein in skin and biofluids. Scientific Awards: Multiple NIH grants (NIEHS, NINDS), DoD funding, MJFF support, and recognition as an NAI Fellow. Advising & Grants: Trained over 30 PhD students, leads a 25-member lab, and has secured continuous federal funding for over two decades. Current projects include drug discovery targeting Kv1.3 and PKD1 pathways. Labs/Teams: Kanthasamy Lab at UGA, Isakson Center collaborations, and partnerships with industry for translational drug development.

Daniel Cifuentesمشاهده پروفایل

دانشیار

• RNA regulation
• Developmental biology
• Virology
• +۳ مورد دیگر

Dr. Daniel Cifuentes is an Associate Professor in the Department of Biochemistry at Boston University, where he leads the Cifuentes Laboratory. His research focuses on RNA regulation mechanisms in two primary model systems: zebrafish embryogenesis and RNA virus replication (e.g., Ebola and Lassa viruses). He integrates high-throughput genetic, genomic, and proteomic approaches to investigate post-transcriptional regulation in development and viral infection. PhD: University of Barcelona, Spain Postdoctoral Training: Yale University Research Interests Molecular mechanisms of RNA-binding proteins and microRNAs Role of RNA modifications in gene expression Transcriptional and translational control in filoviruses and arenaviruses Publications & Trends : His work spans RNA regulatory networks, with recent emphasis on computational approaches (sChemNET), viral RNA stabilization (Ebola), and chromatin organization in blood cell development (miR-144/Hmgn2 axis). Collaborations : Dr. Cifuentes collaborates with Prof. Mühlberger’s group at Boston University’s National Emerging Disease Laboratory (NEIDL) for RNA virus research. Laboratory Members : Owen Sanborn (PhD Student - RNA-Protein Interactions, microRNA) Annie Wen (PhD Student - Biochemistry, Virology)

Robert Schneiderمشاهده پروفایل

استاد

• Epigenetics
• Chromatin
• Histone modifications
• +۵ مورد دیگر

Robert Schneider serves as Director of the Institute for Functional Epigenetics (IFE) at Helmholtz Zentrum München and Professor at the Faculty of Biology, LMU Munich. His academic career spans leadership positions at major European research institutions including IGBMC in Strasbourg and the Max Planck Institute for Immunobiology and Epigenetics in Freiburg. Dr. Schneider's research focuses on epigenetic mechanisms with particular expertise in chromatin biology, histone modifications, and transcriptional memory. His laboratory investigates the molecular basis of epigenetic reprogramming, environment-genome interactions, and metabolic signaling to chromatin. Current work explores how metabolic signals influence chromatin states and how epigenetic information is maintained through cell divisions. His publication record demonstrates consistent contributions to understanding histone modifications, particularly regarding less-studied modifications like propionylation and succinylation, as well as the role of linker histones in chromatin organization. Recent work connects metabolic pathways with epigenetic regulation, showing how cellular metabolites directly influence chromatin states and gene expression patterns. ERC Starting Grant (2007) HFSP Career Development Award (2005) Chaire Gutenberg awarded by Universite de Strasbourg (2011) Ligue Contre la Cancer, Equipe labelisée (2014) Membership of Epigenesys Network of Excellence (2011) As an active member of the epigenetics community, Schneider serves on multiple scientific boards including the Research Coordination Board of the German Center for Diabetes Research since 2017. He has organized numerous major conferences including the 2023 GRC on DNA and Histone Modifications and the annual Munich Epigenetics Spotlight series since 2016. His laboratory maintains strong collaborative networks across Europe through initiatives like the 'Epicrossborders' International Research School which he has led since 2019.

Yongjie Zhangمشاهده پروفایل

دانشیار

• Neuroscience
• Neurodegenerative Diseases
• Frontotemporal Dementia (FTD)
• +۱۱ مورد دیگر

Yongjie Zhang, Ph.D., is an Associate Professor in the Department of Neuroscience at Mayo Clinic, Jacksonville, Florida. He leads a research laboratory focused on understanding the molecular and cellular mechanisms underlying frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), two fatal neurodegenerative disorders that share pathological and genetic features. His work integrates molecular biology, functional assays, and animal modeling to uncover disease pathways and develop novel therapeutic strategies. Dr. Zhang earned his Ph.D. in Neuroscience from Tongji Medical College & Hua-Zhong University of Science and Technology (HUST), an M.S. in Microbiology from Xiamen University, and a B.S. in Biology from Hebei Normal University. His research centers on the pathogenic roles of aggregation-prone proteins, particularly TDP-43 and C9orf72 dipeptide repeat (DPR) proteins. He has developed novel mouse models expressing individual DPR proteins to dissect their specific contributions to neurodegeneration, stress granule dynamics, and behavioral deficits. A key focus is understanding how DPR proteins and TDP-43 co-aggregate in stress granules and drive proteinopathy. He also investigates genetic modifiers and antisense oligonucleotides (ASOs) as potential therapeutics for C9orf72-associated FTD and ALS. Analysis of Dr. Zhang’s recent publications reveals a strong emphasis on TDP-43 pathology, DPR protein toxicity, stress granule biology, and biomarker discovery. His work spans from basic molecular mechanisms to translational applications, including antibody development and therapeutic targeting. There is a consistent trajectory toward identifying and validating novel targets for intervention in ALS and FTD. Target ALS Foundation Grant Program (2017–2019, 2020–2022) ALS Association Research Grant (2014–2017, 2015–2018) Alzheimer's Association New Investigator Research Program (2014–2016) AFAR Affiliate Research Grant Program (2009–2010) Dr. Zhang has served as Principal Investigator (PI) on multiple significant grants, including NIH/NINDS and Alzheimer’s Association projects, demonstrating sustained funding and leadership in neurodegeneration research. His lab actively collaborates with prominent researchers at Mayo Clinic, such as Dr. Leonard Petrucelli and Dr. Tania Gendron. He leads a research team investigating disease mechanisms and therapeutic strategies, supported by active projects on poly(ADP-ribose) in DPR toxicity, mechanisms of DPR-induced cell death, and TDP-43 function.

Andrea Tancrediمشاهده پروفایل

استاد

• Bayesian Inference
• Bayesian Computational Methods
• Biostatistics
• +۹ مورد دیگر

Andrea Tancredi is a Professor at the Department of Methods and Models for Economy, Territory, and Finance, Sapienza University of Rome. His research focuses on Bayesian inference, computational statistics, and their applications in biostatistics, population size estimation, and health economics. He has coordinated multiple research projects funded by the University, including studies on record linkage, approximate Bayesian computation (ABC), and stochastic frontier models. Research Interests: Bayesian Inference Computational Methods (MCMC, ABC) Population Size Estimation Record Linkage and Data Integration Extreme Value Theory Biostatistics and Health Economics Teaching: He teaches courses such as Basic Statistics, Advanced Statistical Methods, and Extreme Value Theory at the Faculty of Economics and doctoral programs in Economics. Publications and Citations: With 47 publications (23 journal articles), his work spans Bayesian modeling for microbial diversity, climate-conflict risk forecasting, and multi-state health models. His research is cited 682 times on Google Scholar (h-index 12) and 401 times in Scopus (h-index 9).