جست‌وجوی استاد و پژوهشگر

• Vascular Physiology
• Ion Channel Regulation
• Hypertension Research
• +۶ مورد دیگر

Thomas Andrew Qvistgaard Jepps is an Associate Professor in the Department of Biomedical Sciences at the University of Copenhagen's Faculty of Health and Medical Sciences, where he leads research on vascular physiology with a focus on circulation, kidney, and lung systems. He also holds a Guest Researcher position in the Department of Drug Design and Pharmacology within the Molecular and Cellular Pharmacology section. Dr. Jepps received his BSc (Hons.) in Biomedical Sciences from St. George's University of London (2005-2008), followed by a PhD from the same institution funded by the Biotechnology and Biological Sciences Research Council (2009-2013). His academic journey includes postdoctoral research at the University of Copenhagen and prestigious fellowships including a Marie Curie Independent Research Fellowship and a Carlsberg Foundation Research Fellowship. His research program centers on understanding vascular ion channel regulation, particularly potassium channels, and their role in hypertension and vascular diseases. Dr. Jepps investigates two primary areas: KCNE ancillary subunits and microtubules in smooth muscle cells, with additional projects on smooth muscle proliferation in atherosclerosis, novel ion channels in angiogenesis, and functional sympatholysis mechanisms. His laboratory employs advanced techniques including isometric tension recordings, electrophysiology, immunostaining, proximity ligation assays, and molecular biology approaches. Analysis of his recent publications reveals a strong focus on vascular tone regulation, with particular emphasis on microtubule function in hypertension, potassium channel modulation by novel compounds, and translational research connecting basic mechanisms to clinical applications such as colchicine for hypertension treatment and understanding drug-induced hypotension. Scientific Recognition: Selected for the 68th Lindau Nobel Laureate Meeting (2018) Multiple best presentation awards at international symposia (2009-2014) Widdicombe Prize in Physiology from St. George's University of London (2009) Regular invitations to present at international conferences and departmental seminars Dr. Jepps has supervised 2 ERASMUS students, 9 bachelor's project students, and 3 Master's students. His research is supported by significant grants including the Carlsberg Foundation Research Fellowship (1,178,053DKK), Lundbeck Foundation Postdoctoral Fellowship (700,000DKK), and a Marie Curie Postdoctoral Fellowship (€199,809). He has organized numerous scientific events including the First International Kv7 Channels Symposium and Cardiovascular Seminar Series at the University of Copenhagen. His laboratory maintains active collaborations with researchers across multiple institutions including Prof. Geoffrey Abbott at UC Irvine (KCNE subunits), Prof. Christian Aalkjær at Aarhus University (microtubules in arteries), and Prof. Anthony Heagerty at the University of Manchester (colchicine for hypertension treatment).

• Angiogenesis Inducing Agents
• Aptamers, Nucleotide
• Biocompatible Materials
• +۱۶ مورد دیگر

Dr. Josephine Allen is a Professor in the Pediatrics Department at the Medical College of Wisconsin, specializing in the Cardiology Division. She serves as the Director of Pediatric Cell and Tissue Engineering and is a member of the Cardiovascular Research Center. Her academic career bridges biomedical engineering and clinical pediatrics with a focus on developing innovative solutions for cardiovascular conditions. Dr. Allen's research interests span a wide range of interdisciplinary fields including: Angiogenesis Inducing Agents and Vascular Endothelial Growth Factor Receptor-2 targeting DNA-Collagen complex biomaterials and hydrogels Biocompatible Materials and Polymers for tissue engineering Cardiovascular Diseases and Vascular Remodeling Sex as a Biological Variable in biomedical research Effects of microgravity on vascular cells Her recent publications demonstrate a strong trajectory in developing novel biomaterial platforms that combine nucleic acid technology with traditional tissue engineering approaches. The work shows particular innovation in creating aptamer-functionalized collagen hydrogels for vascular applications and investigating how biological variables affect tissue engineering outcomes. Dr. Allen has published extensively on the importance of considering sex differences and ancestral background in regenerative engineering, contributing significantly to methodological rigor in the field. Dr. Allen has demonstrated strong leadership in promoting rigorous research practices, as evidenced by her publications addressing underreported variables in biomedical research. Her work on microgravity effects connects terrestrial cardiovascular research with space medicine applications, showing the breadth of her scientific impact. As Director of Pediatric Cell and Tissue Engineering, Dr. Allen oversees research initiatives focused on developing engineered solutions for pediatric cardiovascular conditions. Her laboratory likely investigates novel biomaterials and tissue engineering approaches specifically tailored to the unique challenges of treating cardiovascular conditions in children.

• Lipoprotein metabolism
• HDL (High-Density Lipoprotein) research
• Atherosclerosis
• +۷ مورد دیگر

Mary Sorci Thomas, PhD is a Professor with Tenure in the Department of Medicine, Division of Endocrinology at the Medical College of Wisconsin and in the Department of Pathology Section on Lipid Sciences at Wake Forest University School of Medicine. She serves as Associate Director of the Cardiovascular Center and Associate Program Director of the CVC T32 Training Program at MCW. Dr. Sorci Thomas is an internationally recognized expert in lipoprotein metabolism and HDL research with over 30 years of continuous NIH funding. Dr. Sorci Thomas's research program focuses on the structural and functional properties of apolipoprotein A-I and HDL, with particular emphasis on how these relate to cholesterol transport, inflammation, and atherosclerosis. Her work has provided fundamental insights into the mechanisms of HDL biogenesis, the role of specific apolipoprotein domains in LCAT activation, and the relationship between HDL function and immune regulation. Her laboratory employs a multidisciplinary approach combining protein chemistry, molecular biology, cell culture, and animal models to investigate these processes. Analysis of Dr. Sorci Thomas's recent publications reveals a continued focus on HDL structure-function relationships, with increasing attention to the connections between lipid metabolism, inflammation, and vascular biology. Her work spans basic mechanistic studies of apolipoprotein structure to translational investigations of HDL function in disease processes, demonstrating a consistent trajectory of high-impact research in lipoprotein biology. Established Investigator, American Heart Association (1994-1999) Women's Mentoring Award, American Heart Association (2002) Special Recognition Award, Arteriosclerosis, Thrombosis and Vascular Biology Council (2002) Chair, Gordon Conference on Lipoprotein Metabolism (2006) Chair, Kern Aspen Lipid Meeting (2010-Present) Co-Chair, Atherosclerosis, Thrombosis and Vascular Biology Council of AHA (2016-2022) Dr. Sorci Thomas has mentored numerous students, postdocs, and junior faculty throughout her career. As Associate Program Director of the CVC T32 Training Program at MCW, she continues to play an active role in training the next generation of cardiovascular researchers. Her mentorship extends beyond her own laboratory through her leadership roles in national organizations and scientific review panels.

• Vascular Biology
• Cardiovascular Physiology
• Endothelial Function
• +۵ مورد دیگر

Dr. David X. Zhang is an Associate Professor in the Department of Medicine, Division of Cardiology at the Medical College of Wisconsin, where he is also a member of the Cardiovascular Research Center. His academic career bridges clinical medicine (MD) and basic science research (PhD), positioning him at the forefront of translational cardiovascular research. Dr. Zhang's research focuses on the molecular mechanisms of vascular function, with particular emphasis on endothelial physiology, ion channel regulation (especially TRP channels), and the signaling pathways that control vasodilation and vascular tone. His laboratory investigates how reactive oxygen species (NO, H2O2), calcium signaling, and various mediators regulate human microvascular function in both health and disease states. Key areas of investigation include the role of TRPV4 channels in vascular signaling, mechanisms of endothelial dysfunction in coronary artery disease, and the vascular consequences of inflammatory conditions including SARS-CoV-2 infection. Analysis of Dr. Zhang's recent publication record (2019-2025) reveals a consistent research trajectory focused on molecular vascular mechanisms with direct clinical relevance. His work frequently employs human tissue models, providing translational significance to his findings. The publications demonstrate expertise in multiple methodologies including human microvessel physiology, molecular signaling analysis, and structural biology approaches. His research has made significant contributions to understanding alternative vasodilator mechanisms, ion channel regulation in vascular tissue, and the molecular basis of endothelial dysfunction. Dr. Zhang maintains an active collaborative network, as evidenced by his numerous multi-institutional publications. His work has been published in high-impact journals including Nature Communications, Journal of Biological Chemistry, Arteriosclerosis Thrombosis and Vascular Biology, and Basic Research in Cardiology. While specific grant details aren't provided, the sustained productivity and sophisticated nature of the research suggest substantial ongoing funding support. For students and researchers interested in vascular biology, Dr. Zhang's laboratory offers opportunities to work at the intersection of basic science and clinical cardiovascular research, with emphasis on human vascular physiology and molecular signaling mechanisms that have direct relevance to cardiovascular disease pathogenesis and potential therapeutic targets.

• Vascular Biology
• Lung Development and Regeneration
• Mechanobiology
• +۴ مورد دیگر

Dr. Tadanori Mammoto is an Associate Professor in the Department of Pediatrics at the Medical College of Wisconsin, with a Divisional focus in Neonatology. He is also a member of the Cardiovascular Research Center, reflecting his interdisciplinary research approach spanning vascular biology, lung development, and mechanobiology. Dr. Mammoto's research focuses on the molecular mechanisms underlying vascular development and disease, with particular emphasis on how mechanical forces and extracellular matrix properties regulate cellular behavior. His work has significantly advanced understanding of the YAP/TAZ signaling pathway, Twist1 transcription factor, and angiopoietin-Tie2 system in lung vascular development and regeneration. His laboratory investigates how these pathways contribute to conditions such as pulmonary hypertension and impaired lung development in neonates. Analysis of Dr. Mammoto's publication record reveals a consistent trajectory of high-impact research, with numerous publications in top-tier journals including Nature, Science, and Nature Medicine. His work demonstrates strong translational potential, particularly in developing novel approaches for lung regeneration and understanding vascular complications in neonatal diseases. The increasing focus on organ-on-a-chip technology in recent years reflects his commitment to innovative methodologies for studying human vascular biology. Dr. Mammoto's research has been widely recognized, with several publications receiving hundreds of citations. His work on soluble endoglin in preeclampsia (2006) has been particularly influential, with over 1,600 citations, demonstrating the broad impact of his contributions to vascular biology. His collaborative approach is evident through extensive co-authorship with researchers at Harvard Medical School and affiliated institutions, particularly with Dr. Akiko Mammoto and Dr. Donald Ingber. This collaboration has produced groundbreaking work in organ-on-a-chip technology and vascular mechanobiology, bridging engineering and medical sciences to address complex biological questions. Dr. Mammoto's laboratory represents a dynamic research environment focused on understanding fundamental mechanisms of vascular development while developing innovative approaches to model and potentially treat vascular diseases affecting neonates and adults alike.

Linda Lowe-Krentzمشاهده پروفایل

استاد

• Biochemistry
• Cell & Molecular Biology
• Signal Transduction
• +۳ مورد دیگر

Linda Lowe-Krentz serves as a Professor in the Department of Biological Sciences at Lehigh University, where she leads research in vascular cell biology and signal transduction mechanisms. Education: PhD in Biochemistry and Molecular Biology from Northwestern University Post-doctoral studies at the University of Health Sciences/Chicago Medical School Her research program centers on identifying and characterizing heparin receptors in vascular cells, with specific focus on transmembrane protein 184a (TMEM184a). The Lowe-Krentz lab has delineated signal transduction pathways that regulate smooth muscle and endothelial cell proliferation, migration, and angiogenesis, while current work investigates how heparan sulfate proteoglycans interact with these receptors to modulate vascular function in wound repair contexts. This interdisciplinary work bridges biochemistry, cell biology, and vascular physiology. Analysis of her 2014-2022 publications reveals consistent focus on TMEM184a as a critical heparin receptor, with experimental models spanning zebrafish embryogenesis to mammalian cell cultures. Key trends include elucidating nitric oxide synthase activation mechanisms, TNFα-mediated stress responses, and cGMP-dependent protein kinase pathways in vascular regulation. The work demonstrates strong integration of molecular, cellular, and physiological approaches to address fundamental questions in vascular biology. Scientific Awards: No awards or honors were documented in the provided text. Dr. Lowe-Krentz mentors graduate students as evidenced by asterisked co-authors in publications, though no formal student list is provided. Research grants and funding sources are not specified in the available materials. The Lowe-Krentz lab maintains specialized facilities including vascular cell culture systems and zebrafish models for angiogenesis studies, collaborating with researchers in physiology and molecular biology to advance understanding of vascular repair mechanisms.

• Cardiac physiology
• Inflammatory cardiovascular disease
• Drug-induced cardiotoxicity
• +۵ مورد دیگر

Professor David Greensmith serves as Professor of Cardiac Physiology and Associate Dean for International Development at The University of Salford's School of Science, Engineering & Environment. He is an active researcher, educator, and leader in cardiovascular science with significant contributions to understanding cardiac physiology, inflammatory cardiovascular disease, and drug-induced cardiotoxicity. Greensmith earned his undergraduate degree in Biological Sciences from The University of Salford in 2005, followed by a PhD and two post-doctoral positions in cardiac physiology at The University of Manchester under Professors David Eisner, Mahesh Nirmalan and Andrew Trafford. He returned to Salford in 2014 as a lecturer in Biomedical Science and has since risen to his current professorship. His research focuses on the cellular basis of normal and dysfunctional heart function, with particular emphasis on calcium signaling and oxidative stress mechanisms. Current projects investigate why anti-cancer drugs cause heart failure and how abnormal heart cell function contributes to coronary artery disease. His lab also explores natural product derivatives for cancer treatment, particularly against medulloblastoma and leukemia. Greensmith's recent publications demonstrate his dual focus on cardiac physiology and cancer therapeutics, with significant work on cytokines in coronary artery disease, calcium signaling mechanisms, and natural compounds like Tripterygium wilfordii derivatives. His research spans basic physiological mechanisms to potential clinical applications. The Physiological Society's Otto Hutter Teaching Prize (2023) Associate Editor for Current Research in Physiology President of the British Society for Cardiovascular Research (starting January 2025) Scientific Director of KidsCan (starting January 2025) Physiological Society representative for The University of Salford (since 2017) As an educator, Greensmith has led physiology modules and the Human Biology & Infectious Diseases degree programme. He co-leads initiatives to enhance widening participation in research careers, particularly for students from disadvantaged socioeconomic backgrounds. His 2023 Otto Hutter Teaching Prize recognized his excellence in physiology education. He accepts self-funded PhD students interested in cardiac physiology, drug-induced cardiotoxicity, and natural product-based cancer therapeutics.

• Vascular Physiology
• Exercise Physiology
• Hypertension Research
• +۳ مورد دیگر

Dr. Seher Ülker is a Lecturer in the Department of Physiotherapy and Rehabilitation at Alanya Alaaddin Keykubat University's Faculty of Health Sciences. She holds a PhD in Physiology from Akdeniz University (2018) and previously served as Research Assistant at Akdeniz University's Department of Physiology (2010-2018). Her academic appointments include multiple administrative roles: Deputy Head of Department (2021), Director of Research and Application Center (2020), and General Coordinator for Disabled Students (2019). Her research focuses on vascular physiology mechanisms , particularly carbon monoxide pathways in vascular tone regulation, exercise-induced vascular adaptations, and hypertension models. She investigates how aging, exercise training, magnesium supplementation, and 20-HETE inhibition affect vascular reactivity in resistance/conduction arteries using rodent models. Recent publications (2020-2024) demonstrate continued productivity in journals like Journal of Surgical Research and Turkish Bulletin of Hygiene . Dr. Ülker actively supervises graduate students with four recent theses (2023-2025) on rehabilitation topics including knee osteoarthritis, archery performance, temporomandibular dysfunction, and multiple sclerosis frailty. She teaches 8+ courses annually across undergraduate and graduate programs, covering physiology fundamentals, exercise physiology, and rehabilitation science. Key research contributions: Parabiosis effects on vascular aging (2022) Carbon monoxide regulation in hypertensive models (2020) Exercise adaptations in vascular tone (2019) Magnesium therapy mechanisms in hypertension (2015-2016) 20-HETE pathway in trained vasculature (2018) She has led 6 nationally funded research projects (2009-2018) including TÜBİTAK 1002 support. Dr. Ülker also contributes to rehabilitation literature through book chapters on temporomandibular dysfunction, sarcopenia, and exercise modalities.

• Cardiovascular Physiology
• Vascular Biology
• Hypertension Research
• +۵ مورد دیگر

Joakim Armstrong Bastrup serves as an Assistant Professor in the Department of Biomedical Sciences at the University of Copenhagen's Faculty of Health and Medical Sciences. His research focuses on the physiology of circulation, kidney and lung, with particular emphasis on vascular biology and cardiovascular diseases. His laboratory is located at Blegdamsvej 3B in Copenhagen. Dr. Bastrup's research interests center on vascular physiology, with specific focus on hypertension mechanisms, aneurysm development, and circulatory system function. His work integrates proteomic approaches with vascular biology to investigate molecular mechanisms underlying cardiovascular pathologies. His research spans from basic molecular mechanisms in vascular smooth muscle cells to translational studies with clinical implications for hypertension and vascular diseases. Analysis of Dr. Bastrup's recent publications (2022-2025) reveals a strong focus on proteomic mapping of vascular tissues, particularly in hypertension models. His work consistently explores molecular pathways in vascular smooth muscle, with recurring themes of cytoskeletal dynamics , gene regulation , and vascular remodeling . Several studies investigate animal models of cardiovascular disease, demonstrating translational relevance to human conditions. Dr. Bastrup maintains active collaborations within the cardiovascular research community, as evidenced by his co-authorship with researchers like Thomas Jepps, Christian Aalkjær, and others at the University of Copenhagen. His work appears in high-impact journals including Journal of Biological Chemistry, Scientific Reports, and Pharmacological Research, with several publications receiving notable citations and media attention.

Ylva Hellstenمشاهده پروفایل

استاد

• Cardiovascular Physiology
• Exercise Physiology
• Vascular Function
• +۶ مورد دیگر

Ylva Hellsten serves as Professor and Head of Section at the Department of Nutrition, Exercise and Sports, University of Copenhagen, leading the Cardiovascular Research group within The Integrative Physiology section. She holds dual appointments in The August Krogh Section for Human Physiology and The August Krogh Section for Molecular Physiology. Education: Dr.Med.Sci, Department of Physiology, Karolinska Institute, Stockholm, Sweden (1993) Bachelor of Arts, Hampshire College, Amherst, MA, USA (1987) Professor Hellsten's research focuses on cardiovascular physiology and the effects of physical activity and inactivity . Her work spans human studies and cellular investigations to elucidate molecular mechanisms underlying vascular function. Key research areas include estrogen loss effects on vascular health in women, endothelial and smooth muscle cell mitochondria in vascular function, pericytes in skeletal muscle angiogenesis, Pannexin-1 channel roles in hypertension, remote ischemic preconditioning mechanisms, and physical activity impacts on platelet function and blood clot formation. Recent publications demonstrate strong trends in exercise-induced vascular adaptations , blood clotting mechanisms , and sex-specific physiological responses . Her work frequently examines skeletal muscle microvasculature, cardiovascular responses in special populations (postmenopausal women, athletes, stroke patients), and molecular signaling pathways related to exercise adaptation. Research Group: 3 Post-doctoral researchers 4 PhD students Multiple Master's students Technical staff

• Microcirculation
• Vascular Adaptation
• Flow Regulation
• +۵ مورد دیگر

Jens Christian Brings Jacobsen is an Associate Professor at the Department of Biomedical Sciences within the Faculty of Health and Medical Sciences at the University of Copenhagen, where he leads research in the Renal and Vascular Research group. His work focuses on computational models of microcirculation and vascular dynamics, addressing fundamental questions about the relationship between blood vessel structure and function. His primary research interests include: Computer models of microvessels Structural adaptation in vascular networks Simulation of individual vascular cells and groups of cells Microcirculation and arterial blood pressure interactions Dr. Jacobsen's research examines how blood pressure influences the structure of the smallest blood vessels and how the microcirculation affects arterial blood pressure. His work also investigates how the body ensures that microcirculation can continuously meet changing tissue needs through models of flow regulation, vascular networks, the myogenic response, vascular conducted responses, intracellular calcium dynamics, vasomotion, and synchronization. His research spans multiple disciplines including physiology, computational biology, and medical engineering. His recent publications demonstrate expertise across multiple domains including endocrinology, metabolism, cardiology, nephrology, gerontology, and vascular physiology. His work typically involves collaborative research with international teams across multiple institutions, reflecting the interdisciplinary nature of his research questions. Scientific contributions: Current supervisor for 2 PhD students Reviewer for 8 different journals Member of study board for Health Informatics at University of Copenhagen Extensive teaching experience in physiological modeling and related subjects Dr. Jacobsen maintains an active research program with numerous collaborations across different countries and institutions, as evidenced by his extensive publication record, conference presentations, and research outputs. His work continues to advance our understanding of microvascular physiology and its implications for human health and disease.

• Vascular Biology
• Immunobiology
• Transplantation Immunology
• +۷ مورد دیگر

Jordan Pober, MD, PhD is the Bayer Professor of Translational Medicine and Professor of Immunobiology, Pathology, and Dermatology at Yale School of Medicine. He serves as Director of the Human and Translational Immunology Program and Vice-Chair of the Department of Immunobiology for the Section of Human and Translational Immunology. Dr. Pober is also co-founder and co-director of the Joint Yale-Cambridge University Biomedical Research Program and a visiting fellow at the University of Cambridge. Dr. Pober's research focuses on understanding blood vessel functions in human inflammatory and immune responses, and how inflammation and immunity affect vascular health. His work addresses three interrelated problems in vascular endothelial cell biology: T lymphocyte recognition of antigens presented by vascular cells, signaling pathways activated by immune cells within endothelial cells, and pathways of cell injury induced by leukocytes. His experimental approaches involve cultured cell populations, chimeric animal models, and human tissue analysis. His recent publications demonstrate strong activity across multiple disciplines including vascular biology, transplantation immunology, tissue engineering, and mathematical modeling of biological systems. The research output shows consistent productivity with numerous high-impact publications in 2024-2025 across journals like Nature Communications, American Journal of Transplantation, and Nature Cardiovascular Research. Searle Scholar Established Investigator of the American Heart Association MERIT awardee of the National Heart, Lung and Blood Institute Warner Lambert-Parke Davis award (1988) Rous Whipple Award (2011) from the American Society of Investigative Pathology Earl Benditt award (2014) from the North American Vascular Biology Organization Basic Science Established Investigator Award (2018) from the American Society of Transplantation Bohmfalk Prize for Teaching (2019) Election to Connecticut Academy of Science and Engineering (2023) Dr. Pober has served as Editor of Immunity and Co-Editor-in-Chief of Laboratory Investigation. He was President of the North American Vascular Biology Organization and has directed multiple research programs at Yale. His international collaboration with the University of Cambridge represents a significant research partnership that facilitates exchange of knowledge and resources between institutions. His work has direct clinical applications in improving transplantation outcomes and advancing tissue engineering techniques.

• Vascular Biology
• Endothelial Cell Biology
• Macrophage Biology
• +۹ مورد دیگر

Dr. Yajaira Suarez is the Anthony N. Brady Professor of Comparative Medicine and Deputy Chair of the Department of Comparative Medicine at Yale School of Medicine. She also holds a secondary appointment as Professor of Pathology and is an active member of the Yale Cancer Center, Vascular Biology and Therapeutics Program, and Yale Center for Molecular and Systems Metabolism. Dr. Suarez earned her BS and PhD in Biochemistry and Molecular Biology from Universidad Autonoma de Madrid (1995, 2001), followed by postdoctoral training at Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (2002-2005) and Yale University School of Medicine (2005-2009). She began her independent research career at New York University School of Medicine in 2009 before joining Yale in 2013. Her research program focuses on understanding novel regulatory mechanisms in endothelial cell and macrophage functions, particularly examining non-coding RNAs, metabolic rewiring, immunometabolism, and cholesterol regulation. This work has significant implications for atherosclerosis, cancer, and metabolic diseases. Her publication record demonstrates consistent high-impact research in top-tier journals including Nature Communications, Journal of Clinical Investigation, and PNAS. Dr. Suarez's research output shows a clear focus on the intersection of vascular biology and metabolism, with recent publications (2021-2025) emphasizing endothelial cell metabolism, macrophage immunometabolism, and non-coding RNA regulation in cardiovascular and metabolic diseases. Her work has established her as a leader in understanding how metabolic pathways regulate vascular function and inflammation. Recipient of the 2025 Judah Folkman Award in Vascular Biology Elected member of Connecticut Academy of Science and Engineering (2022) Werner Risau New Investigator Award in Vascular Biology Kingsley Award in Medical Research from Yale School of Medicine Fellowship-Grant Award from CNIC P3+3 programme for Post-doctoral Careers in Biomedicine Dr. Suarez maintains active collaborations with numerous researchers at Yale and internationally. Her lab employs a multidisciplinary approach combining molecular and cellular biology, biochemistry, and genetically modified mouse models. Her recent work has significant translational potential for developing novel therapies for cardiovascular diseases, cancer, and metabolic disorders.

Nuno Guimarães-Camboaمشاهده پروفایل

استادیار

• Vascular Biology
• Cardiovascular Diseases
• Aneurysmal Diseases
• +۳ مورد دیگر

Dr. Nuno Guimarães-Camboa is a Junior Research Group Leader at the Institute for Cardiovascular Regeneration, Goethe University Frankfurt, funded by the German Centre for Cardiovascular Research (DZHK). His research focuses on transcriptional mechanisms in perivascular cells and their critical roles in vascular stability and diseases including aneurysms and cardiac fibrosis. His work investigates perivascular cell biology (pericytes, vascular smooth muscle, adventitial fibroblasts) using integrated in vitro and in vivo models. These cells regulate vascular permeability and contribute to pathologies such as cancer, obesity, and organ fibrosis. His long-term goal is developing novel therapeutic strategies for aneurysmal diseases and cardiac fibrosis through molecular pathway targeting. Analysis of his 2014-2020 publications reveals consistent focus on perivascular cell lineage tracing and functional roles. Key contributions include establishing fibroblasts as adipocyte progenitors, disproving bone marrow origins of infarct fibroblasts, and demonstrating pericytes' non-stem cell behavior in vivo. His work bridges vascular development, disease mechanisms, and regenerative medicine through advanced molecular techniques. Scientific recognition includes: Junior Research Grant from the DZHK Excellence Program (2018) Schulman Award for Outstanding Research, University of California, San Diego (2016) As DZHK-funded group leader, he directs cardiovascular research utilizing fluorescence microscopy and genetic lineage tracing. His team trains next-generation scientists in vascular biology while investigating molecular pathways for therapeutic translation. Current work emphasizes clinical applications for aneurysm and fibrosis treatments. His laboratory at Goethe University Frankfurt's Institute for Cardiovascular Regeneration operates within the DZHK network, combining cellular models with disease pathology studies to advance diagnostic and therapeutic approaches for vascular disorders.

Lars Maegdefesselمشاهده پروفایل

استاد

• vascular disease
• atherosclerosis
• aortic aneurysm
• +۴ مورد دیگر

Lars Maegdefessel is a Professor of Molecular Vascular Medicine at the Technical University Munich (TUM), School of Medicine and Health. He leads the Experimental Vascular Medicine unit at Klinikum rechts der Isar and serves as a DZHK Junior Group Leader. His research focuses on the therapeutic and biomarker potential of non-coding RNAs in vascular diseases including atherosclerosis, aortic aneurysm, and related vascular pathologies. Dr. Maegdefessel's research interests center on the role of non-coding RNAs in vascular diseases, with particular focus on the vulnerability of atherosclerotic vascular lesions and the progression and rupture of abdominal aortic aneurysms. His laboratory utilizes unique human biobank materials and various pre-clinical experimental models to investigate novel molecular approaches for combating cardiovascular diseases. His work spans from basic research on microRNAs, long non-coding RNAs, and circular RNAs to translational applications in vascular medicine. Analysis of Dr. Maegdefessel's publication record reveals a strong focus on non-coding RNA mechanisms in vascular pathology, with particular emphasis on atherosclerosis stabilization, aneurysm development, and vascular inflammation. His research has evolved from basic miRNA characterization to sophisticated therapeutic applications including targeted delivery systems and novel biomarker discovery. The publications demonstrate a consistent trajectory toward clinical translation of RNA-based vascular therapeutics. ERC Consolidator Grant (2023) Russel Ross Award from American Heart Association (2023) Heisenberg Professorship of German Research Foundation (2016) Werner Risau Award of American Heart Association (2016) ERC Starting Grant (2015) Prince Daniel Research Award of Swedish Heart and Lung Foundation (2014) Ragnar Söderberg Fellowship in Medicine (2014) Dr. Maegdefessel's research program includes extensive collaboration with international teams and utilizes advanced methodologies including RNA sequencing, microarrays, proteomics, and epigenomic analyses. His laboratory investigates ncRNA function in human vascular tissues and pre-clinical models, with recent work focusing on artery-on-a-chip technology and novel therapeutic delivery systems for vascular applications.