جستجوی استاد راهنمای دانشگاهی

Jeff F. Millerمشاهده پروفایل

استاد

• Microbiology
• Immunology
• Molecular Biology
• +۴ مورد دیگر

Jeff F. Miller is a Professor in the Department of Microbiology, Immunology & Molecular Genetics (MIMG) at the University of California, Los Angeles (UCLA). His research focuses on understanding mechanisms of pathogen survival and adaptation, particularly through diversity-generating retroelements (DGRs) in bacteria and phages, and their implications for vaccine development and infection control. Positions: Principal Investigator on multiple NIH grants focusing on microbial pathogenesis and vaccine vectors Research Themes: Bacterial pathogenesis, phage biology, type III secretion systems, and immunological responses His work spans from fundamental studies of bacterial evolution to translational research in vaccine design and antimicrobial strategies. Notable contributions include elucidating the role of DGRs in generating protein diversity and mechanisms of intracellular bacterial survival. Miller has held leadership roles in NIH-funded training programs in microbial pathogenesis. Publications highlight interdisciplinary approaches, combining structural biology, genomics, and immunology to address challenges in infectious diseases. His lab collaborates across disciplines to advance understanding of host-pathogen interactions and apply findings to clinical solutions.

• Structural Biology
• Microbiology
• Biochemistry
• +۵ مورد دیگر

Dr. Morgan Beeby is an Associate Professor in Structural Biology at the Department of Life Sciences, Imperial College London, within the Faculty of Natural Sciences. He leads research into the molecular machinery of cells, employing electron cryo-tomography to visualize cellular processes at near-atomic resolution. As co-director of the MRes in Structural Biology, he oversees advanced training programs and maintains an active lab focused on microbial structural biology. His work integrates cutting-edge imaging techniques with phylogenetics and genetics to explore the assembly, function, and evolution of molecular machines like bacterial flagella and archaella. Research interests include microbiology, biochemistry, and cell biology, with a focus on understanding how cellular components such as flagella, archaella, and secretion systems operate and evolve. His group investigates the structural basis of motility, protein interactions, and cellular processes in pathogens like Campylobacter jejuni and Staphylococcus aureus , leveraging cryo-ET and computational modeling. Publications highlight advancements in flagellar motor structure, archaellum function, and the evolution of bacterial secretion systems. The lab’s methodologies include high-throughput cryo-tomography and subtomogram averaging to resolve complex macromolecular assemblies in situ. Collaborative efforts aim to bridge structural insights with functional genomics, particularly in environmental and medical microbiology contexts. Dr. Beeby’s contributions extend to educational leadership through the MRes program and lab management. He actively disseminates findings via peer-reviewed journals and maintains a lab website for ongoing research updates. His work emphasizes translational applications in understanding microbial pathogenesis and structural biology’s role in advancing medical and environmental science.

Craig B. Wilenمشاهده پروفایل

دانشیار

• Virology
• RNA Viruses
• Host-Pathogen Interactions
• +۵ مورد دیگر

Craig B. Wilen, MD, PhD, serves as an Associate Professor in both Laboratory Medicine and Immunobiology at Yale School of Medicine. He holds dual appointments as Associate Professor of Laboratory Medicine (primary tenure) and Associate Professor on Term in Immunobiology. Dr. Wilen also serves as Medical Director of the Immune Monitoring Core Facility and is affiliated with multiple Yale research centers including the Center for Infection and Immunity, Center for RNA Science and Medicine, Human and Translational Immunology Program, and Yale Cancer Center. Dr. Wilen's educational background includes an AB in Biology and Economics from Washington University in St. Louis (2006), followed by combined MD/PhD training at the University of Pennsylvania Perelman School of Medicine (PhD 2011, MD 2013). He completed residency training in Clinical Pathology at Barnes-Jewish Hospital in St. Louis (2016) and conducted postdoctoral studies in the laboratory of Herbert 'Skip' Virgin at Washington University School of Medicine. His research focuses on host-pathogen interactions of RNA viruses, particularly coronavirus and norovirus. Dr. Wilen discovered CD300lf as the first receptor for norovirus and identified intestinal tuft cells as the physiologic target cell for mouse norovirus infection. Current work in the Wilen Lab investigates mechanisms of immunity and pathogenesis for noroviruses, coronaviruses, and pre-emergent viruses with pandemic potential. His research employs cutting-edge approaches including genome-wide CRISPR screens, animal models, and human tissue studies to understand viral entry, immune evasion, and pathogenesis. Analysis of Dr. Wilen's recent publications (2023-2025) reveals consistent focus on viral pathogenesis mechanisms across multiple RNA virus families. His work bridges basic virology with translational applications, examining viral receptors, host immune responses, and potential therapeutic interventions. The publications demonstrate strong collaborative networks across Yale and with external institutions, particularly in the areas of norovirus persistence mechanisms and coronavirus host interactions. Young Faculty Award 2024 from DARPA Odyssey Award 2023 & 2022 from Smith Family Foundation Young Physician-Scientist Award 2021 from American Society for Clinical Investigation Robert E. Leet and Clara Guthrie Patterson Trust Mentored Research Award 2020 Dr. Wilen leads an active research program through the Wilen Lab at Yale School of Medicine, where his team investigates viral pathogenesis and immunity. As Medical Director of the Immune Monitoring Core Facility, he oversees critical infrastructure for immunological research at Yale. His laboratory maintains strong connections with clinical departments while pursuing fundamental questions about how viruses interact with host cells and immune systems. The lab's work has significant implications for developing improved diagnostics, therapeutics, and vaccines for viral diseases.

Alan R Hauserمشاهده پروفایل

استاد

• Infectious Diseases
• Microbiology
• Bacterial Pathogenesis
• +۳ مورد دیگر

Dr. Alan R Hauser is a Professor in the Department of Microbiology-Immunology and Medicine (Infectious Diseases) at Northwestern University Feinberg School of Medicine. He serves as Vice Chair of Microbiology-Immunology and Director of Feinberg’s Medical Scientist Training Program (MSTP). BA, St. John's University (1982) MS, PhD, MD, University of Minnesota (1985, 1990, 1992) Postgraduate Training: University of Minnesota Medical Center (1993-1994), UCSF (1996, 1999) His research focuses on the pathogenesis of multidrug-resistant gram-negative bacteria, including Pseudomonas aeruginosa , Acinetobacter baumannii , and Klebsiella pneumoniae . Key areas include virulence factors like type III secretion systems, genomic approaches to identify novel virulence determinants, and translational strategies to combat bacterial infections. His lab utilizes molecular/cellular assays, animal models, and epidemiological studies. Recent publications highlight advancements in pharmacokinetic/pharmacodynamic modeling for ICU antibiotic therapies, genomic insights into bacterial colonization mechanisms, and novel methodologies for virulence quantification using Galleria mellonella . These works span disciplines including Infectious Diseases, Genomics, and Clinical Pharmacology. Scientific Awards: Tripartite Legacy Faculty Prize in Translational Science and Education (2024) Faculty Mentor of the Year Award (2024) Multiple Teaching Pin Awards (2016-2021) Fellow, American Academy of Microbiology (2016) Dr. Hauser actively contributes to editorial boards (e.g., Infection and Immunity ), scientific advisory roles (Microbiotix, Inc.), and professional societies (Infectious Diseases Society of America, American Society for Microbiology). His lab collaborates with institutes like the Center for Genetic Medicine and NUCATS.

• Vaccine Development
• Immunology
• Microbiology
• +۵ مورد دیگر

F. Heath Damron is an Associate Professor and Director of the Vaccine Development Center at the West Virginia University Health Sciences Center. His primary academic appointment is in the Department of Microbiology, Immunology & Cell Biology within the WVU School of Medicine, and he also serves as Director of the MD-PhD Program at WVU Health Sciences Center. Dr. Damron's research program focuses on vaccine development against bacterial pathogens including Bordetella pertussis (whooping cough) and Pseudomonas aeruginosa, as well as viral pathogens like SARS-CoV-2. His work spans multiple areas of immunology and microbiology, with emphasis on understanding host-pathogen interactions and developing novel vaccine platforms. His laboratory investigates multiple vaccine approaches including mRNA vaccines, virus-like particle (VLP) vaccines, and whole-cell formulations, with significant contributions to understanding pertussis vaccine efficacy and waning immunity. His recent publications demonstrate a strong focus on mRNA-based vaccines, monoclonal antibody therapeutics, and innovative animal challenge models. Dr. Damron has published extensively in high-impact journals including NPJ Vaccines, Infection and Immunity, and Frontiers in Cellular and Infection Microbiology, with a notable increase in output since 2020 reflecting his active research program addressing emerging infectious disease threats. As Director of the Vaccine Development Center, Dr. Damron leads a multidisciplinary team focused on translating basic research discoveries into clinical applications. His dual leadership roles in both vaccine development and the MD-PhD Program highlight his commitment to advancing scientific discovery while training the next generation of physician-scientists at WVU.

Edward Miaoمشاهده پروفایل

استاد

• Immunology
• Microbiology
• Cell Death Mechanisms
• +۵ مورد دیگر

Edward Miao, MD, PhD is a Professor at Duke University with dual appointments in the Department of Immunology and Department of Molecular Genetics and Microbiology . His research program centers on gastrointestinal innate immunity against infections in intestines and liver, utilizing both in vivo models and organoid cultures. Primary research areas: Inflammasome biology, Cell death mechanisms, Host-pathogen interactions Key model pathogens: Salmonella , Chromobacterium violaceum , Staphylococcus aureus Major discoveries: Caspase-7's role in intestinal epithelial extrusion, NLRC4 inflammasome's translocation sensing, Hepatocyte niche for bacterial infection Recent publication trends (2023-2025) focus on: Expanding inflammasome functions beyond canonical roles Comparative studies of gasdermin activation across species Novel insights into epithelial repair mechanisms Immune response dynamics in liver infections Reactive oxygen species in antibiotic tolerance Evolution of regulated cell death nomenclature Dr. Miao's laboratory has made significant contributions to understanding: How pathogens manipulate caspase activity Non-traditional roles of cell death proteins Organoid culture applications in infection biology Granuloma formation efficiency in liver infections

Anne McCabeمشاهده پروفایل

استادیار

• Bacterial Pathogenesis
• Molecular Microbiology
• Klebsiella pneumoniae
• +۵ مورد دیگر

Anne McCabe is an Assistant Professor at Albany College of Pharmacy and Health Sciences with a strong research focus on bacterial pathogenesis, particularly studying Klebsiella pneumoniae and its survival mechanisms during infection. She earned her BA in Molecular and Cellular Biology from Harvard University, PhD in Molecular Biology from Princeton University, and completed an IRACDA Postdoctoral Fellowship in the Department of Molecular Biology and Microbiology at Tufts University. Dr. McCabe's research interests focus on understanding how opportunistic pathogens like Klebsiella pneumoniae survive diverse environmental stressors, including oxidative stress from the innate immune response and antibiotic treatment during infection. Her work spans bacterial stress response mechanisms, host-pathogen interactions, metal ion transport, and outer membrane biogenesis. Analysis of her publication record from 2016-2024 reveals a strong focus on bacterial pathogenesis with particular emphasis on Klebsiella pneumoniae as a model organism. Her research combines molecular microbiology, structural biology, and infectious disease approaches to understand bacterial survival mechanisms during host infection. Key themes include antibiotic resistance mechanisms, bacterial metabolism during infection, and structural analysis of bacterial transport systems. Her scientific contributions include important discoveries related to Klebsiella pneumoniae's ability to resist neutrophil killing, the role of amino acid biosynthesis in bacterial survival during lung infection, and structural insights into metal transport systems. Her 2024 publication on growth medium effects on drug interactions in Gram-negative bacteria represents her most recent contribution to the field.

Ethel Bayer-Santosمشاهده پروفایل

استادیار

• Microbiology
• Infectious Diseases
• Bacterial Pathogenesis
• +۲ مورد دیگر

Dr. Ethel Bayer-Santos is an Assistant Professor in the Department of Molecular Biosciences at the University of Texas at Austin's College of Natural Sciences. Her research focuses on microbial conflicts, particularly bacterial competition mechanisms using specialized nanoweapons like the Type VI Secretion System (T6SS). She completed her B.Sc. in Biological Sciences, Ph.D. in Microbiology and Immunology, and postdoctoral training in infectious diseases. Her educational background spans institutions in Brazil and the UK. Research in her lab investigates: Antibacterial effector mechanisms Polymorphic toxin functions Salmonella-microbiota interactions Protein evolution in bacterial warfare Nuclease activities in interbacterial conflicts Publications consistently focus on molecular mechanisms of bacterial secretion systems, effector functions, and host-pathogen interactions. Recent work emphasizes structural characterization of antibacterial toxins and regulatory mechanisms of microbial weaponry. Awards include: FAPESP Young Investigator Luiz Trabulsi Award in Science The EBSlab employs interdisciplinary approaches combining microbiology, biochemistry, and structural biology to understand bacterial competition. Current projects examine how pathogens overcome colonization resistance and establish infections through specialized molecular weaponry.

Barbara Kunkelمشاهده پروفایل

استاد

• Plant Pathology
• Plant-Microbe Interactions
• Bacterial Virulence
• +۳ مورد دیگر

Barbara Kunkel is Professor of Biology and Associate Chair of Undergraduate Education at Washington University in St. Louis. Her research investigates signaling and regulatory events governing interactions between bacterial plant pathogens (particularly Pseudomonas syringae) and their hosts (Arabidopsis thaliana), focusing on molecular pathogenicity mechanisms and plant signaling pathway modifications. Research areas include: Molecular basis of Pseudomonas syringae pathogenicity Plant physiological responses to virulence factors Auxin's role in plant-pathogen interactions Bacterial virulence gene regulation Her publications demonstrate consistent focus on hormone-mediated plant-pathogen interactions, particularly auxin signaling mechanisms in disease susceptibility. Scientific awards: AAAS Fellow (2020)

• Molecular Microbiology
• Bacterial Physiology
• Flagellar Biology
• +۳ مورد دیگر

Prof. Dr. Marc Erhardt is a Full Professor of Molecular Microbiology at Humboldt-Universität zu Berlin, Germany, and a Max Planck Fellow at the Max Planck Unit for the Science of Pathogens. His academic career includes prior roles as Associate Professor (W2) at Humboldt-Universität and a Principal Investigator at the Helmholtz Centre for Infection Research. He holds a PhD from the University of Konstanz (summa cum laude) and completed postdoctoral work at Université de Fribourg and the University of Heidelberg. His research focuses on bacterial physiology, flagellar biology, and type III secretion systems, with notable contributions to understanding flagellar assembly mechanisms and bacterial motility. Erhardt has received prestigious awards including the ERC Consolidator Grant (2019) and the VAAM Forschungspreis (2018). His work spans structural biology, pathogen-host interactions, and synthetic biology tools for microbial systems. Education: PhD in Molecular Microbiology (2011), University of Konstanz Diploma in Biology (2006), University of Ulm, Konstanz, and University of Utah Research interests include the molecular mechanisms of flagellar assembly, bacterial motility regulation, and the interplay between bacterial physiology and pathogenicity. Key achievements include discoveries on flagellin incorporation mechanisms, anti-phage defense systems, and CRISPRi-mediated bacterial regulation. Erhardt's lab (AG Bacterial Physiology) employs advanced microscopy, structural biology, and synthetic biology approaches to explore bacterial nanomachines and infection strategies. His research has led to over 60 publications in journals like Cell , Nature Communications , and PLOS Biology . Awards & Grants: ERC Consolidator Grant (2019) Helmholtz Young Investigator Grant (2013–2017) Marie Curie International Fellowship (2012–2013) His research group develops novel tools for studying bacterial systems, including fluorescent markers for Gram-negative bacteria and regulatory systems for synthetic biology. Current projects address flagellar dynamics, microbiota interactions, and the structural basis of bacterial pathogenesis.

Andrew J. Darwinمشاهده پروفایل

استاد

• Microbiology
• Bacterial Pathogenesis
• Pseudomonas aeruginosa
• +۴ مورد دیگر

Andrew J. Darwin is a Professor in the Department of Microbiology at NYU Langone Health. His research focuses on bacterial pathogenesis, particularly the role of proteases and stress response systems in Pseudomonas aeruginosa and Yersinia enterocolitica . His work explores cell envelope dynamics, proteolytic regulation, and bacterial virulence mechanisms. Academic Rank: Professor University: NYU Langone Health Email: andrew.darwin@nyulangone.org Dr. Darwin's research investigates protease activation mechanisms, such as CtpA hexameric assembly in Pseudomonas aeruginosa , and stress responses like the Psp system in Yersinia enterocolitica . He examines how proteases regulate cell wall homeostasis, mucoidy, and antibiotic resistance, as well as the interplay between secretion systems and bacterial survival during infections. Recent publications highlight protease-regulated cell envelope stress responses, including novel activation mechanisms for CtpA protease (2024) and inhibitor systems for lytic transglycosylases (2023). His work spans structural biology, enzymology, and bacterial physiology, with a focus on chronic infection models and virulence strategies.

• Plant Pathology
• Translational Plant Biology
• Molecular Plant-Microbe Interactions
• +۵ مورد دیگر

Joyce Elberse is a Researcher and Teacher in the Translational Plant Biology group within the Department of Biology at Utrecht University's Faculty of Science. With over 15 years of active research, she contributes significantly to understanding plant-pathogen interactions, particularly focusing on downy mildew resistance mechanisms in various crops. Institution: Utrecht University Faculty: Faculty of Science Department: Biology Research Group: Translational Plant Biology Position: Researcher and Education Assistant Dr. Elberse's research primarily centers on plant immunity mechanisms, with particular emphasis on how plants defend against pathogens like downy mildew. Her work spans molecular plant-microbe interactions, effector biology, and the biochemical pathways involved in plant defense responses. She has made significant contributions to understanding the role of oxygenase enzymes like DMR6 in plant immunity regulation, as well as studying pathogen effectors in spinach and lettuce downy mildew systems. Analysis of her publication record shows consistent research focus on plant-pathogen interactions, with a clear progression from fundamental biochemical studies of plant immunity regulators to applied research on crop resistance mechanisms. Her recent work has increasingly focused on spinach and lettuce pathogens, addressing practical agricultural challenges through molecular understanding of resistance breaking and pathogen evolution. Dr. Elberse has collaborated extensively with Guido van den Ackerveken's research group, contributing to multiple high-impact publications in journals such as PNAS, Plant Journal, and Molecular Plant. Her research demonstrates strong translational potential for developing disease-resistant crop varieties.

• Bacterial genetics
• Bacterial sensory signal transduction
• Biofilms
• +۶ مورد دیگر

Dr. Sampriti Mukherjee is an Assistant Professor in the Department of Molecular Genetics and Cell Biology at the University of Chicago. Her research focuses on understanding how bacteria decode and integrate self-generated and environmentally-derived stimuli to control transitions between individual and collective behaviors, particularly in the context of biofilm formation and bacterial pathogenesis. Dr. Mukherjee received her BS and MS in Microbiology from the University of Calcutta (2007 and 2009), followed by a PhD in Microbiology from Indiana University (2014). She completed her postdoctoral training in Molecular Biology at Princeton University in 2020. Her laboratory employs a multidisciplinary approach combining bacterial genetics, molecular biology, biochemistry, microfluidics, fluorescence microscopy, and genome-scale studies to investigate bacterial signal detection, relay, and integration mechanisms. Her research has significant implications for developing strategies to combat antibiotic-resistant infections by targeting bacterial communication systems rather than bacterial growth directly. The work has revealed novel mechanisms of bacterial communication, including the discovery of new quorum-sensing autoinducers and their receptors, the integration of photosensing with quorum sensing, and the regulation of biofilm development through combinatorial control of multiple signaling pathways. Dr. Mukherjee's research has been recognized with several prestigious awards: Searle Scholars Program (2022-2025) NIH Pathway to Independence Award (K99/R00, 2018-2023) Life Sciences Research Foundation Postdoctoral Fellowship (2016-2019) She currently leads multiple NIH-funded research projects as Principal Investigator, including R35GM150803 "Probing the role of sensory cues in the regulation of bacterial biofilm development" (2023-2028) and R00GM129424 "A New Quorum-Sensing Autoinducer Acts with the RhlR Receptor to Control Virulence and Biofilms in Pseudomonas Aeruginosa" (2018-2023), demonstrating her significant contributions to the field of bacterial signal transduction and pathogenesis. Dr. Mukherjee's lab is part of the vibrant research community in the Department of Molecular Genetics and Cell Biology at the University of Chicago, collaborating with researchers studying bacterial pathogenesis, signal transduction, and microbial communities to advance our understanding of bacterial collective behaviors and their implications for human health.

Marc Vallsمشاهده پروفایل

استاد

• Plant Pathology
• Molecular Plant-Microbe Interactions
• Bacterial Diseases in Plants
• +۳ مورد دیگر

Marc Valls is a Full Professor at the University of Barcelona (UB) , leading the research program Plant Responses to Stress and the Malalties bacterianes i proteòstasi de les plantes group. His research focuses on bacterial plant pathogens, particularly Ralstonia solanacearum , and mechanisms of plant proteostasis and stress response. He works in the CRAG (Centre de Recerca en Agrigenòmica) Building on the UAB Campus. Research Interests : Marc Valls investigates plant-pathogen interactions, emphasizing bacterial wilt resistance, metacaspase functions in cell death regulation, and effector protein dynamics. His work spans Molecular characterization of plant immune responses Role of proteases in disease susceptibility Transcriptomic and metabolomic profiling during infection Development of hydroponic infection models Genetic determinants of pathogen virulence Chemical barriers in vascular immunity Scientific Trends : Recent publications highlight his focus on Ralstonia solanacearum virulence, plant immune signaling (e.g., FERONIA pathways), effector-triggered immunity, and stress-induced proteostasis. Key themes include cytokinin signaling, ligno-suberin coatings, and metacaspase-mediated cell death. Collaborative efforts target type III secretion inhibitors for disease management. Scientific Awards : Premio al mejor póster presentado en el XXXVI Congreso, Valencia (2015) Labs & Teams : Based in the CRAG Building (Lab 1.03), his team explores plant stress responses and bacterial disease mechanisms. Contact: Office 1.13, +34 935636600 ext 3132 (Office), +34 935636600 ext 3121 (Lab).

• Bacterial Pathogenesis
• Microbiology
• Gene Regulation
• +۵ مورد دیگر

Erin Green is an Assistant Professor in the Department of Microbiology at the University of Chicago. Her research focuses on understanding the mechanisms by which bacterial pathogens, particularly Acinetobacter baumannii , adapt to environmental stresses and transition between environmental reservoirs and mammalian hosts. Dr. Green's primary research interests include: Bacterial pathogenesis of nosocomial infections Mechanisms of bacterial desiccation tolerance Gene regulation in response to environmental stress Bacterial signal transduction pathways Proteostasis in bacterial pathogens Metal homeostasis in bacterial pathogens Her work has significant implications for understanding how multidrug-resistant pathogens like A. baumannii persist in hospital environments and cause infections. Through her research on bacterial hydrophilins and their role in desiccation tolerance, Dr. Green has contributed important insights into how pathogens survive on dry surfaces, which is a major factor in hospital-acquired infections. Dr. Green has published extensively on bacterial pathogenesis, with particular focus on A. baumannii and Staphylococcus aureus . Her recent publications (2023-2025) examine zinc homeostasis mechanisms in A. baumannii , arginine metabolism in antibiotic tolerance, and the molecular basis of desiccation tolerance in bacterial pathogens. Her laboratory, the Green Lab, is actively investigating the mechanisms driving transmission and virulence of nosocomial bacterial pathogens, with a particular emphasis on understanding how these pathogens sense and adapt to long-term desiccation stress.