جست‌وجوی استاد و پژوهشگر

Guillaume Bourqueمشاهده پروفایل

استاد

• Bioinformatics
• Computational Genomics
• Comparative Genomics
• +۵ مورد دیگر

Guillaume Bourque is a Professor in the Department of Human Genetics at McGill University's Faculty of Medicine. He serves as an Investigator at the Victor Phillip Dahdaleh Institute of Genomic Medicine and as the Scientific Director of the Canadian Centre for Computational Genomics (C3G). His laboratory is based at 740 Dr Penfield Ave, Room 6103, Montréal, Québec, Canada, H3A 1A4, where he leads research in computational genomics and bioinformatics. Professor Bourque's research focuses on understanding mammalian genomes using comparative genomic and epigenomic analyses. His lab investigates the evolution of regulatory sequences , the role of transposable elements in gene regulation , and the impact of genome rearrangements in evolution and cancer . His team develops computational methods and resources for the functional annotation of genomes with special emphasis on sequencing-based assays including ChIP-seq, RNA-Seq, exome- and whole-genome sequencing, and single-cell analysis. The lab's work involves examining billions of DNA base pairs to interpret how variation impacts basic biology and disease. Recent publications (2024-2025) demonstrate Bourque's leadership in pangenome graph construction , transposable element analysis , epigenomic profiling , and cancer genomics . His work spans multiple disciplines from basic genome evolution to clinical applications in cancer and infectious disease. Notable projects include the development of tools like DeepPolisher for genome assembly polishing and contributions to understanding the genomic basis of long COVID. Bourque's laboratory is actively recruiting postdocs and graduate students with backgrounds in programming or statistics. The lab emphasizes quantitative approaches to biology, requiring applicants to have experience in quantitative biology as a plus. His collaborative work extends across multiple institutions and international consortia, reflecting the interdisciplinary nature of modern genomic research.

Jill A Kreilingمشاهده پروفایل

دانشیار

• Aging Biology
• Molecular Biology
• Cell Biology
• +۴ مورد دیگر

Jill A Kreiling is an Associate Professor (Research) in the Department of Molecular Biology, Cell Biology, and Biochemistry at Brown University School of Medicine. She also serves as the Associate Director of the Brown Center on the Biology of Aging since July 2018. Her research focuses on the molecular mechanisms of aging, particularly examining the role of transposable elements, epigenetic changes, and cellular senescence in the aging process. Dr. Kreiling's research interests span several key areas in aging biology and molecular mechanisms of age-related changes. Her work has significantly contributed to understanding how retrotransposable elements become active during aging, how heterochromatin formation changes with age, and how these molecular changes impact tissue function and age-related diseases. She has developed innovative approaches to study aging processes using various model systems including mouse models, zebrafish, and cell culture systems. Her research program has been consistently supported by NIH funding, including her current role as Principal Investigator on an R01 grant focused on identifying biomarkers in salivary vesicles for preclinical Alzheimer's disease. She has published extensively in high-impact journals including Nature, Cell, and Aging Cell, with her work being cited widely in the aging research community. Dr. Kreiling has received several prestigious awards including the Mentored Research Scientist Development Award (K01) from the National Institute on Aging (2011-2017). Her collaborative network includes prominent researchers in the aging field such as John Sedivy and Nicola Neretti at Brown University. As an educator, Dr. Kreiling has taught Introductory Microbiology and has mentored numerous students and postdoctoral fellows in her laboratory. Her research program provides valuable training opportunities for students interested in aging research, molecular biology, and translational approaches to age-related diseases.

• Plant Genetics
• Berry Crop Breeding
• Molecular Biology
• +۵ مورد دیگر

Timo Hytönen is a Professor in the Department of Agricultural Sciences at the University of Helsinki's Faculty of Agriculture and Forestry. He holds a Docentship in the same department and is an integral member of the Viikki Plant Science Centre (ViPS). His academic leadership extends to supervising doctoral students across three major programs: Sustainable Use of Renewable Natural Resources, Integrative Life Science, and Plant Sciences. Additionally, he maintains an external position as Principal Research Scientist at NIAB EMR in Genetic Genomics & Breeding since November 2018. Professor Hytönen's research interests span plant genetics, molecular biology, and crop production sciences with a specialized focus on berry crops, particularly strawberries. His work investigates fundamental plant processes including flowering time regulation, environmental adaptation mechanisms, fruit development, and disease resistance. His research integrates genomic, transcriptomic, and epigenetic approaches to understand how plants respond and adapt to environmental challenges. His extensive publication record (88 publications) reveals a strong focus on woodland strawberry (Fragaria vesca) as a model system for studying economically important traits in berry crops. Recent work demonstrates expertise in QTL mapping, genome-wide association studies, circadian rhythm adaptation, and the genetic basis of climate adaptation. His research shows consistent emphasis on translating basic science into practical applications for crop improvement. Professor Hytönen leads significant research projects including 'Mansikan vihreä vallankumous' (Strawberry Green Revolution) funded by the Academy of Finland and 'ASTROS: How meristems guide plant reproductive development' supported by the Jane and Aatos Erkko Foundation. He is also a Principal Investigator in the Viikki Plant Science Centre (ViPS), a major collaborative research infrastructure. His academic service includes extensive peer review activities (37 manuscript reviews), hosting academic visitors (32 instances), and participation in numerous conferences and seminars. He has provided guidance to graduate students and supervised doctoral candidates, contributing significantly to the training of next-generation plant scientists.

Andreas Kauttمشاهده پروفایل

استادیار

• Evolutionary Genetics
• Behavioral Ecology
• Adaptive Radiation
• +۲ مورد دیگر

Andreas Kautt is Assistant Professor of Biology at Washington University in St. Louis, investigating evolutionary mechanisms driving biological diversity through integrative approaches combining genomics, behavioral experiments, and fieldwork. Research focuses on two primary systems: North American deer mice and Missouri crayfish. Research themes include: Genomic basis of behavioral divergence and sensory evolution Molecular mechanisms of speciation in cichlid fish radiations Genetic assimilation in morphological evolution Development of novel genomic tools for speciation research Recent work explores olfaction genetics in deer mice, parallel evolution in pigmentation, and hybrid speciation mechanisms. Publications demonstrate expertise in evolutionary genomics, behavioral ecology, and molecular evolution across diverse vertebrate systems.

Anne Ferguson-Smithمشاهده پروفایل

استاد

• Genomic Imprinting
• Epigenetics
• Developmental Genetics
• +۳ مورد دیگر

Professor Anne Ferguson-Smith is a leading mammalian developmental geneticist and epigeneticist at the University of Cambridge, holding the Arthur Balfour Professorship of Genetics. As Pro-Vice-Chancellor for Research, she oversees the university's research strategy while maintaining her laboratory's focus on genomic imprinting and epigenetic inheritance . Her work bridges experimental and computational approaches through affiliations with the Cambridge Stem Cell Institute, Cambridge Neuroscience, and the Centre for Trophoblast Research. Research in her lab investigates epigenetic mechanisms in developmental processes , particularly through the lens of Dlk1-Dio3 imprinted domain studies. Current themes include: Stem cell epigenetic programming Environmental modulation of epigenetic states Role of repetitive elements in genomic regulation Her group integrates mouse and zebrafish models with high-throughput genomics and mathematical modeling . Key collaborations include: Wellcome Trust UKRI Medical Research Council BBSRC NIH Scientific honors include: Elected EMBO Member (2006) Academy of Medical Sciences (2012) Fellow of the Royal Society (2017) Commander of the Order of the British Empire (CBE) The lab maintains family-friendly research practices and actively participates in interdisciplinary collaborations across Cambridge and internationally.

Ritwick Sawarkarمشاهده پروفایل

عضو هیئت علمی

• Chromatin Biology
• Environmental Stress Response
• Transcriptional Regulation
• +۳ مورد دیگر

Ritwick Sawarkar is a Principal Investigator at the MRC Toxicology Unit and affiliated with the Department of Genetics under the School of Biological Sciences at the University of Cambridge. He leads the Sawarkar Group, focusing on molecular mechanisms linking chromatin biology, environmental stress response, and transcriptional regulation. Education: PhD in Genetics (Indian Institute of Science, 2010) Previous roles: Postdoctoral Fellow at ETH-Zürich (2010-2014), Independent Group Leader at Max Planck Institute (2014-2019) Research Interests : The Sawarkar Group investigates how chromatin interprets environmental stress signals to modulate transcriptional responses. Key questions include: (i) Cellular pathways sensing stress/toxins, (ii) Chromatin's role in stress adaptation, and (iii) Transcriptional mechanisms for cellular survival. Their work integrates genomics, single-cell transcriptomics, proteomics, and mouse models to explore stress response pathways. Article Trends : Recent publications highlight his expertise in chromatin-mediated stress responses, non-coding RNA interactions, and proteostasis networks. Collaborations with pharmaceutical companies emphasize translational applications for drug toxicology and RNA therapeutics. Scientific Awards : ERC Consolidator Grant (2018) Alfred Tissières Young Investigator Award (2019) Group Members : His team includes PhD students (Dimitris Aspri, Roberto Campalastri), Research Associates (Simone Baldan, Christo Christov), and MPhil students (Anfas Muhammed, Keely Xia), among others.

Stephen L Helfandمشاهده پروفایل

استاد

• Molecular Genetics of Aging
• Longevity
• Neurodegeneration
• +۷ مورد دیگر

Stephen L Helfand is the George D. Eggleston Endowed Professor of Biochemistry at Brown University, where he serves as Professor in the Department of Molecular Biology, Cell Biology and Biochemistry and Vice-Chair of Research in the Department of Neurology. His work focuses on the molecular genetics of aging , using Drosophila melanogaster to investigate how chromatin changes, transposable elements, and metabolic pathways like the INDY gene influence longevity and age-related diseases. Education: BS (1975) and MD (1979) from Stanford University and Albert Einstein College of Medicine Key Research Areas: Mechanisms of aging Chromatin remodeling Transposable elements in aging Metabolic regulation of lifespan Neurodegenerative disease models His 15 most recent articles (2019-2011) highlight interdisciplinary work bridging genetics, epigenetics, and metabolism. Common themes include chromatin dynamics , mitochondrial function , and transposable element activation in aging, with applications to human diseases like Alzheimer's. Scientific Awards Glenn Awards (2007-2009, 2014-2016) MERIT Award (2004-2016) Fellow of AAAS (2017) and Gerontological Society of America (2017) NIH grants (R01AG067306, R01AG024353, P01AG051449) He contributes to translational neuroscience and aging research through affiliations with Brown University's Center for Computational Molecular Biology , Carney Institute for Brain Science , and Center for Translational Neuroscience . His lab has developed rapid assays for lifespan-extending interventions and demonstrated connections between sirtuins, caloric restriction, and p53 regulation.

Jef D. Boekeمشاهده پروفایل

استاد

• synthetic biology
• genome engineering
• genomics
• +۵ مورد دیگر

Jef D. Boeke is the Sol and Judith Bergstein Director of the Institute of Systems Genetics and a Professor in the Department of Biochemistry and Molecular Pharmacology at NYU Grossman School of Medicine. He holds a PhD from Rockefeller University and has pioneered research in synthetic biology, retrotransposition mechanisms, and yeast genetics. His work includes leading the international Sc2.0 project to synthesize the first eukaryotic genome and the 'Dark Matter Project' exploring non-coding DNA functions. Research interests focus on genome engineering, synthetic genomics, epigenetics, and applications to cancer biology. His lab develops CRISPR tools and synthetic regulatory systems, with notable contributions to understanding LINE-1 retrotransposons and chromatin structure. Over 489 publications highlight his work in Nature Communications, Molecular Cell, and Science. Awards: While specific prizes aren't listed, his leadership in groundbreaking projects like Sc2.0 and contributions to synthetic biology underscore his influential career. Grants and funding details are implied through active research programs. Advising: Supervises a multidisciplinary team of postdocs and graduate students working on projects ranging from antibiotic engineering to de-extinction approaches. Lab collaborations include international partnerships and industry-driven biotech applications. Labs/Teams: Directs the Boeke Lab, a hub for synthetic genome engineering and systems genetics. The lab’s interdisciplinary team bridges molecular biology, computational biology, and engineering to solve complex biological problems.

Louis Lambrechtsمشاهده پروفایل

پژوهشگر

• Arbovirus transmission
• Insect-virus interactions
• Mosquito genetics
• +۱۲ مورد دیگر

Louis Lambrechts is a Researcher and Head of the Insect Infection & Immunity Group at the Institut Pasteur in Paris, France, within the Department of Virology. His research focuses on the ecology, evolution, and genetics of mosquito-virus interactions, particularly involving Aedes aegypti and arboviruses such as dengue and Zika. He leads a dynamic research team and multiple national and international projects funded by agencies including ANR and EU consortia. His research interests include arbovirus transmission dynamics, vectorial capacity, mosquito genetics, evolutionary ecology, host-pathogen interactions, and the role of microbiota in vector competence. He employs genomics, quantitative genetics, and experimental evolution to understand the mechanisms underlying variation in mosquito susceptibility to viral infection. His work has important implications for predicting and controlling arboviral disease outbreaks. Lambrecht’s recent publications reveal key insights into the genetic and environmental factors influencing arbovirus transmission, including the role of mosquito population variation in Zika transmission in Africa, the impact of endogenous viral elements, and the discovery of antiviral roles for cytochrome P450 enzymes. His research integrates molecular biology, field studies, and computational modelling, contributing to a comprehensive understanding of vector-borne disease systems. He has mentored numerous PhD students, postdoctoral researchers, and visiting scientists, fostering a collaborative and interdisciplinary research environment. His lab collaborates widely with institutions across Europe, Africa, and the Americas. Lambrecht’s work is supported by multiple ongoing projects such as CAZIKANO, INTRANZIGEANT, ANR PILGRIM, and LIPOARBO-IVI, focusing on Zika virus transmission, genetic drivers of vectorial capacity, and mosquito-virus specificity. His lab is also involved in broader initiatives like the LabEx IBEID and the Emerging Infectious Diseases program at Institut Pasteur.

Julie Ahringerمشاهده پروفایل

استاد

• Chromatin Regulation
• Epigenetics
• Genome Organization
• +۳ مورد دیگر

Julie Ahringer is Professor of Genetics and Genomics at the University of Cambridge and Director of the Wellcome Trust/Cancer Research UK Gurdon Institute. She leads a research group investigating chromatin structure and gene regulation using C. elegans as a model system. Her work integrates genomics, super-resolution microscopy, and computational approaches to understand epigenetic controls in development and disease. She holds fellowships from the Royal Society (FRS) and Academy of Medical Sciences (FMedSci). Research Focus: Her laboratory studies chromatin regulation mechanisms including heterochromatin formation, Polycomb domain function, genome architecture, and enhancer/promoter interactions. Key approaches include single-cell multiomics, high-throughput genomics, and super-resolution microscopy to analyze developmental trajectories. Research areas span: H3K27me3 domain formation and Polycomb repression Constitutive heterochromatin organization Regulatory element characterization 3D genome architecture via ARC-C technology Single-cell resolution developmental mapping Awards & Honors: Fellow of the Royal Society (FRS) Fellow of the Academy of Medical Sciences (FMedSci) Wellcome Senior Research Fellowship Academic Leadership: She mentors PhD students and postdoctoral researchers, with funding from Wellcome, MRC, and CRUK. Her lab develops open-source bioinformatics tools (VplotR, periodicDNA) and maintains the genome-wide C. elegans RNAi feeding library. Lab & Collaborations: The Ahringer Lab is based at the Gurdon Institute and collaborates widely on chromatin dynamics, nuclear organization, and developmental genomics projects across model organisms.

Tao Wuمشاهده پروفایل

استادیار

• Epigenetics
• Cancer Biology
• DNA Methylation
• +۳ مورد دیگر

Tao Wu is an Assistant Professor in the Department of Molecular and Human Genetics at Baylor College of Medicine in Houston, TX. His research focuses on deciphering epigenetic mechanisms underlying cancer therapeutic resistance, particularly exploring DNA modifications like N6-methyladenine (6mA) and their roles in glioblastoma and other cancers. He employs advanced genomic technologies such as SMRT-ChIP and single-cell sequencing to study epigenetic regulators and their functional implications. Dr. Wu received his PhD from the University of Chinese Academy of Sciences (2008) and completed postdoctoral training at the Yale Stem Cell Center. His work integrates systems biology, genomics, and biochemistry to identify novel epigenetic drug targets. Key discoveries include identifying ALKBH1 as a 6mA demethylase and revealing 6mA’s role in hypoxia response pathways linked to drug resistance in glioblastoma. His research interests emphasize understanding dynamic epigenetic regulation in cancer, with projects focused on: Elucidating driver epigenetic mutations in cancer progression Developing therapies to overcome treatment resistance via epigenetic modulation Characterizing novel DNA modifications (e.g., 6mA) and their regulatory mechanisms Recent work highlights the lab’s focus on single-molecule sequencing and CRISPR-based screening to uncover epigenetic pathways in cancer models. Funding support includes grants from the Cancer Prevention Research Institute of Texas (CPRIT).

Chuanzhu Fanمشاهده پروفایل

دانشیار

• Molecular Evolution
• Genomics
• Epigenomics
• +۲ مورد دیگر

Chuanzhu Fan is an Associate Professor in the Department of Biological Sciences at Wayne State University's College of Liberal Arts and Sciences . His research spans molecular evolution, genomics, and epigenomics with a focus on plant biology. Education : Ph.D. from North Carolina State University (2003), Postdoctoral Research at University of Chicago (2006) Research interests include investigating the genetic and epigenetic mechanisms behind genomic novelty origination and functionalization in plants. He combines studies in Arabidopsis and Oryza species to explore how genomic divergences drive phenotypic differentiation through computational analysis and high-throughput experiments. Recent publications highlight his work in plant gene duplication, DNA methylation patterns in human sperm, rice genomics, and evolutionary dynamics of transposable elements. His lab also develops bioinformatic tools like the gKaKs pipeline for genome-level Ka/Ks calculations. Teaching includes graduate courses in Molecular Evolution (BIO6060) and Genomics (BIO5150/BIO7150), and undergraduate Genetics (BIO3070). Laboratory (Biological Science Building 5107) integrates comparative transcriptomics, DNA methylation manipulation, and phenotyping technologies to study evolutionary novelties in plant genomes.

• Molecular genetics
• Behavioral genetics
• Learning and memory
• +۳ مورد دیگر

Christopher Jones is a Professor of Biology at Moravian University. He has been affiliated with the institution since 1999, where he teaches courses in molecular biology and genomics. Jones is actively involved in the Genome Consortium for Active Teaching (GCAT) and the Genomics Education Partnership (GEP), integrating advanced genomic research into undergraduate education through initiatives like DNA microarray analysis and collaborative annotation of Drosophila genomic data. B.A. in Biology and Russian, Haverford College M.Phil. in Molecular Biophysics & Biochemistry, Yale University Ph.D. in Molecular Biophysics & Biochemistry, Yale University His research focuses on molecular genetics , particularly the genetic basis of learning and memory in Drosophila melanogaster . Earlier work explored bacterial flagellar assembly, including studies on Salmonella typhimurium as a postdoctoral fellow at Cold Spring Harbor Laboratory. Jones' work spans neurological research (Alzheimer's disease via presenilin gene analysis), genomics pedagogy, and evolutionary biology. Key article trends include genomics education (2014-2020), Drosophila memory mechanisms (1997-2007), and foundational bacterial motility studies (1985-1992). His work with GEP and GCAT demonstrates commitment to course-based undergraduate research experiences (CUREs). Scientific Awards : NIH Postdoctoral Fellow Henry Wendt Neuroscience Fellow Jones mentors students through research collaborations, with Moravian undergraduates appearing as co-authors on publications. He contributes to genomics education through curriculum development and national partnerships. His laboratory work historically focused on bacterial flagellar complexes and Drosophila neurogenetics.

Cassandra G. Extavourمشاهده پروفایل

استاد

• Evolutionary Developmental Biology
• Germ Cell Specification
• Reproductive System Evolution
• +۳ مورد دیگر

Cassandra G. Extavour is the Timken Professor of Organismic and Evolutionary Biology and Molecular and Cellular Biology at Harvard University, and a Howard Hughes Medical Institute Investigator. She holds a joint appointment in the Department of Molecular and Cellular Biology and is affiliated with Harvard College. Her research focuses on the evolution and development of germ cells and reproductive systems in arthropods, particularly exploring mechanisms of germ cell specification and the evolutionary transitions in developmental processes. Extavour's work integrates molecular genetics, comparative embryology, and evolutionary theory to study model organisms like spiders, crickets, and fruit flies. She leads the Extavour Lab at Harvard's Biological Laboratories, which collaborates with institutions globally. Notable contributions include discoveries about germ cell specification diversity across arthropods and the role of developmental constraints in life-history evolution. Her educational roles include teaching courses on invertebrate biology and integrated science at Harvard. Recent accolades include her HHMI Investigator status and recognition in Quanta Magazine for career contributions. The lab actively engages in genomic projects, such as cricket genome analysis, and explores molecular mechanisms underlying evolutionary innovations. Students and postdocs in her lab investigate topics ranging from germ line determinants to symbiotic influences on gene evolution.

Janine Deakinمشاهده پروفایل

استاد

• Genomics
• Chromosome Evolution
• Marsupial Genetics
• +۲ مورد دیگر

Janine Deakin is Professor and Executive Dean of the Faculty of Science and Technology at the University of Canberra. She holds a PhD from Macquarie University (1998) and completed postdoctoral research at the University of Texas Health Science Center and Australian National University. Her research focuses on comparative genomics, chromosome evolution, and conservation genetics in marsupials and reptiles. Education: PhD in Immunological relationship of mother-pouch young relationships in the brushtail possum, Macquarie University (1998) Her research explores chromosomal speciation, sex determination mechanisms, and transmissible cancers like devil facial tumour disease, with strong emphasis on conservation applications. She employs cutting-edge genomic technologies to understand evolutionary adaptations in Australian wildlife. Recent publications demonstrate a consistent focus on chromosome dynamics across species, utilizing Hi-C mapping, telomere analysis, and comparative genomics to investigate genome reorganization in reptiles, marsupials and mammals. Her work frequently bridges molecular biology with conservation priorities. Scientific Awards: ARC Future Fellowship (2010) She has supervised numerous PhD students and leads collaborative initiatives including the Oz Mammals Genomics consortium. Her laboratory investigates chromosomal rearrangements impacting gene flow in threatened species.