Transgenic Mouse Models Professors and Supervisors | ApplySharif

جست‌وجوی استاد و پژوهشگر

استاد راهنما، استاد دانشگاه یا پژوهشگر مناسب برای مسیر پژوهشی‌تان را پیدا کنید و با او ارتباط بگیرید.

نمایش ۶۹۱-۷۰۵ از ۱٬۳۸۱ استاد راهنما

اطلاعات این پروفایل‌ها از صفحات عمومی دانشگاه‌ها جمع‌آوری شده و ممکن است به‌روز نباشد.

Madeline McLeodمشاهده پروفایل

استادیار

St. Mary's UniversityUnited States

Madeline McLeod, Ph.D., is an Assistant Professor in the Department of Biological Sciences at St. Mary's University, joining the institution in August 2024. She teaches undergraduate courses in forensic science and general biology. Education: Ph.D. in Forensic Science, Sam Houston State University B.S. in Biology, Texas A&M University Research Focus: Dr. McLeod specializes in advancing forensic DNA analysis for non-human species and challenging human samples including touch DNA, mitochondrial DNA, mixed templates, and degraded DNA. Her work develops next-generation sequencing methods to enhance forensic identification accuracy and applicability in criminal investigations. Publication Analysis: Her research output reveals dual expertise in forensic botany (particularly Cannabis and Papaver species analysis) and molecular aging mechanisms. Recent publications emphasize forensic applications, with significant contributions to plant DNA profiling for drug differentiation and biogeographical tracking, alongside innovations in human DNA recovery from complex evidence. Professional Experience: Prior to her faculty role, Dr. McLeod served as a Molecular Biologist at Signature Science, LLC, where she led government-contracted forensic DNA research and acted as subject matter expert for multi-disciplinary teams.

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Wei Cuiمشاهده پروفایل

دانشیار

University of Massachusetts AmherstUnited States

Mammalian oocyte maturation and activation
Preimplantation embryo development
Animal model generation
+۵ مورد دیگر

Dr. Wei Cui is an Extension Associate Professor in the Department of Veterinary and Animal Sciences at the University of Massachusetts Amherst and serves as Director of the Animal Models Core Facility. Dr. Cui's research focuses on mammalian oocyte maturation and activation, preimplantation embryo development, and animal model generation using advanced genome editing techniques. Ph.D. from Shandong Agricultural University, China (2013) Postdoctoral training at University of Kansas Medical Center (2013-2014) Postdoctoral training at University of Massachusetts Amherst (2014-2017) Dr. Cui's research explores the cellular and molecular mechanisms underlying mammalian oocyte meiosis, activation, and aging, as well as the discovery of novel genes and signaling pathways required for embryo development. Current work also focuses on creating animal models of human genetic diseases using CRISPR/Cas9 technology. Research publications span several important areas including reproductive biology, developmental genetics, and biotechnological applications for embryo culture. Dr. Cui has published extensively on topics related to oocyte maturation, early embryo development, and techniques for improving animal model generation. Lalor Foundation Postdoctoral Fellowship, 2015 As Director of the Animal Models Core Facility, Dr. Cui oversees services for transgenic animals, gene targeting, and embryo micromanipulation. The facility supports researchers through cutting-edge technologies and customized services for animal model development.

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Joseph Watsonمشاهده پروفایل

استاد

University of California, Los AngelesUnited States

Joseph Watson is a Professor and Associate Dean in the Graduate Division of the College of Letters and Science at the University of California, Los Angeles, with primary academic appointment in the Department of Psychiatry & Biobehavioral Sciences within the David Geffen School of Medicine. He also serves as Outreach Program Director for the Brain Research Institute (BRI). His educational background includes: Ph.D. in Chemistry and Biochemistry, UCLA (1985) Postdoctoral Fellowship in Molecular Biology of the Nervous System, The Scripps Research Institute (1989) Dr. Watson's research centers on neurodegenerative disease mechanisms , with intensive focus on synaptic targets in Parkinson's , Huntington's , and Alzheimer's diseases . His work integrates molecular neuroscience, protein biochemistry, and electrophysiology to investigate protein aggregation (alpha-synuclein, amyloid beta), mitochondrial dysfunction , and synaptic plasticity deficits using transgenic mouse models. He has pioneered methodologies for synaptoneurosome preparation to study subcellular mechanisms. Analysis of his 1997-2013 publications reveals consistent investigation of neurodegenerative pathways across Huntington's and Parkinson's models, with recurring themes of oxidative stress in aging , CaMKII signaling , and adenylyl cyclase modulation . His work bridges basic synaptic physiology with translational applications, including exercise interventions and pharmacological targeting of adenosine receptors. Dr. Watson has held significant academic leadership roles including Vice Chair of UCLA's Neuroscience Undergraduate Interdepartmental Program. His outreach initiatives, particularly Project Brainstorm , demonstrate commitment to neuroscience education through K-12 partnerships. He maintains active laboratory research within the Brain Research Institute while fulfilling administrative duties as Associate Dean.

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Xiangdong William Yangمشاهده پروفایل

استاد

University of California, Los AngelesUnited States

Dr. Xiangdong William Yang is a Professor in Residence in the Department of Psychiatry & Biobehavioral Sciences at the David Geffen School of Medicine, University of California, Los Angeles. He is also a member of the Center for Neurobehavioral Genetics at Semel Institute for Neuroscience & Human Behaviors and the Brain Research Institute at UCLA. Dr. Yang serves as a regular member at the NIH's Cell Death in Neurodegeneration Study Section and is a Scientific Advisory Board member of the Hereditary Disease Foundation. Dr. Yang's educational background includes: Combined M.S. and B.S. degrees with summa cum laude from Molecular Biophysics & Biochemistry Department at Yale University (1991) Ph.D. in Molecular Genetics and Neuroscience from Rockefeller University (1998) M.D. from Weill Medical College of Cornell University (2000) Medicine Internship at New York-Presbyterian Hospital (2001) His primary research focuses on Huntington's disease pathogenesis, where he investigates cellular and molecular mechanisms of neurodegeneration. Dr. Yang's laboratory pioneered the BAC transgenic technology for modeling human diseases and developed the innovative MORF (MOnonucleotide Repeat Frameshift) methodology for sparse cell labeling to reveal brain-wide neural circuitry. His work spans genetic mechanisms of CAG repeat expansion, basal ganglia circuitry, microglial responses in neurodegeneration, and molecular pathways underlying selective neuronal vulnerability. Dr. Yang's recent publications demonstrate a strong emphasis on Huntington's disease mechanisms, particularly examining CAG repeat expansion dynamics, neuronal vulnerability patterns, and potential therapeutic approaches. His work increasingly incorporates multi-omics approaches including epigenetics, transcriptomics, and advanced imaging to uncover the complex interplay between genetic mutations and cellular dysfunction. Recent publications also show expansion into Alzheimer's disease research, particularly regarding microglial function and amyloid pathology. Dr. Yang has received numerous prestigious awards recognizing his contributions to neuroscience: The Terry Semel Chair in Alzheimer's Disease Research and Treatment, UCLA (2019) Elected Member, American Society for Clinical Investigation (2017) Leslie Gehry Brenner Prize for Innovation in Science, Hereditary Disease Foundation (2014) Center for Excellence in Education Outstanding Alumni in STEM and Business (2013) The Carol Moss Spivak Scholar in Neuroscience, UCLA (2011-2016) McKnight Neuroscience of Brain Disorders Award (2009-2012) As a principal investigator, Dr. Yang has mentored numerous graduate students and postdoctoral fellows in neuroscience research. His laboratory has been consistently supported by major grants from the NIH, Hereditary Disease Foundation, and other organizations focused on neurodegenerative diseases. Dr. Yang has served on the NIH's Cell Death in Neurodegeneration Study Section, evaluating grant proposals in his field of expertise. His research has directly contributed to preclinical development of therapeutic approaches for Huntington's disease. Dr. Yang leads a vibrant research laboratory at the Gonda Neuroscience & Genetics Research Center at UCLA. His team has developed innovative methodologies including the MORF sparse cell labeling technique for mapping brain circuitry. The lab collaborates extensively with other neuroscience researchers at UCLA and internationally, contributing to large consortia studying neurodegenerative diseases. Current research focuses on uncovering the molecular and circuit-level mechanisms of Huntington's disease with the goal of identifying therapeutic targets.

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Cassy Spillerمشاهده پروفایل

پژوهشگر ارشد

University of QueenslandAustralia

Dr. Cassy Spiller is a Research Fellow at the School of Biomedical Sciences, The University of Queensland. She is a member of the Bowles group, focusing on developmental reproductive biology and germ cell research. Her work spans sex determination, meiosis regulation, and the intersection of toxicology with reproductive mechanisms. Education : Bachelor of Science (University of Newcastle), PhD (University of Queensland, 2009). Her research interests include: Developmental Biology: Mechanisms of germ cell fate and sex differentiation. Reproductive Biology: Regulation of meiosis in fetal gonads. Toxicology: Impact of environmental chemicals on reproductive development. Genetics: Role of signaling pathways (e.g., BMP, STRA8, NFIX) in germ cell development. Article Trends : Recent publications emphasize chemical toxicity, meiosis transitions, and biomarker discovery in testicular cancers, with collaborations across developmental biology, toxicology, and genetics. Scientific Awards : Society for Reproductive Biology Open Grant ARC Discovery Projects Cancer Council Queensland UQ Postdoctoral Fellowship Dr. Spiller is available for supervision and has advised PhD projects on germ cell meiosis, Cripto signaling, and NFIX function. She contributes to adverse outcome pathways in toxicology and is involved in ex vivo culture systems. Her work is supported by grants from national and international foundations.

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Steven Greenمشاهده پروفایل

استاد

University of IowaUnited States

Steven Green is a Professor in the Department of Biology at the University of Iowa's College of Liberal Arts and Sciences, where he leads the Green Lab investigating neurodegeneration, neural regeneration, and neuroimmune interactions in the mammalian cochlea. His research has significant implications for understanding and treating hearing loss, particularly in developing therapeutic interventions to protect or regenerate auditory neurons following trauma. Education: PhD, California Institute of Technology Dr. Green's research program focuses on the mechanisms of neurodegeneration in the peripheral auditory system, particularly how hair cell damage leads to spiral ganglion neuron (SGN) death through inflammatory and immune responses. His lab investigates noise-induced cochlear synaptopathy (NICS), commonly known as "hidden hearing loss," which occurs without profound hearing impairment but causes difficulties in speech comprehension in noisy environments. The Green Lab has identified that noise causes increased glutamate release leading to calcium influx through Ca 2+ -permeable AMPA receptors (CP-AMPARs), and has developed selective blockers to prevent this damage. They also study strategies for promoting synapse regeneration using small-molecule compounds that can be delivered systemically, and have discovered sex differences in recovery involving progesterone mechanisms. Analysis of Dr. Green's recent publications reveals a strong trajectory from basic mechanisms of auditory neurodegeneration toward translational applications. His work spans immunology, molecular neuroscience, and pharmacology with consistent focus on neuroinflammation, calcium-mediated excitotoxicity, and neural regeneration pathways. The research demonstrates progression from identifying fundamental pathological mechanisms to developing targeted therapeutic interventions, with increasing emphasis on sex differences and regenerative approaches in recent years. Research Funding: Grants from the NIH/National Institute on Deafness and Other Communication Disorders (NIDCD) Hearing Restoration Research Program of the Department of Defense The Green Lab employs transgenic rat and mouse models to investigate neuroimmune interactions in the cochlea. Current projects include identifying specific immune components responsible for SGN death, developing novel CP-AMPAR blockers for preventing noise damage, investigating small-molecule approaches for synapse regeneration, and exploring the role of progesterone in female recovery from auditory trauma. The lab's work bridges basic neuroscience with clinical applications for hearing disorders, with particular relevance to military personnel exposed to occupational noise and patients receiving cochlear implants.

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Jochen Staigerمشاهده پروفایل

استاد

University of GöttingenGermany

Jochen Staiger is a Full Professor and Director of the Department of Neuroanatomy at the University Medical Center Göttingen, University of Göttingen, where he leads research on cortical microcircuits and thalamo-cortical interactions. He is affiliated with multiple graduate programs under the Göttingen Graduate Center for Neurosciences (GGNB), including Neurosciences (IMPRS), Sensory and Motor Neuroscience, Cellular and Molecular Physiology of the Brain (CMPB), and Molecular Biology of Cells (GZMB). Dr. med., Justus Liebig University Giessen (1993), summa cum laude Habilitation in Anatomy, Heinrich Heine University Düsseldorf (2000) W3 Professor of Cell Biology, Albert-Ludwigs-University Freiburg (2006) His research focuses on the synaptic architecture of neocortical microcircuits, particularly in the barrel cortex, examining how thalamo-cortical inputs shape cortical processing, how inhibitory interneurons organize layer-specific circuits, and how sensory experience drives genomic and structural plasticity. He uses transgenic mouse models, including the reeler mutant, to study cortical function in both normally laminated and dysplastic cortices. The recent publications (2015–2020) reflect a strong focus on VIP and parvalbumin-expressing interneurons, neuromodulation, layer-specific connectivity, and functional organization of cortical columns. Key themes include synaptic targeting, burst-tonic transitions, brain-wide connectivity mapping, and compensation in malformed cortices. No scientific awards were mentioned in the provided text. Prof. Staiger leads an active research group with a focus on fundamental neuroscience questions. His lab investigates how cortical circuits develop, function, and adapt, with implications for understanding neurodevelopmental disorders. The team employs advanced neuroanatomical, genetic, and imaging techniques to dissect circuit motifs. While no formal students are listed, his collaborative publications suggest mentorship of junior researchers. His research group maintains a dedicated homepage: http://www.neuroanatomie.uni-goettingen.de/ and a specialized site on barrel cortex research: http://neuro.ukat.gwdg.de/barrels/ .

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Basile Tarchiniمشاهده پروفایل

دانشیار

University of MaineUnited States

Basile Tarchini is an Associate Professor at the Graduate School of Biomedical Science and Engineering, affiliated with The Jackson Laboratory. His research focuses on the molecular and developmental mechanisms of sensory hair cells in the inner ear, particularly stereocilia morphogenesis and its implications for hearing and balance. Education: PhD, University of Geneva, Switzerland (2004) His work bridges developmental biology and molecular genetics, using mouse models to investigate transcriptional regulation, cytoskeleton polarization, and hereditary hearing loss. Recent publications highlight roles of G proteins, kinases, and synapse maturation in hair cell function. Selected Research Themes: Molecular basis of hair cell sensory ability Cytoskeleton polarization in stereocilia Therapeutic strategies for hair cell regeneration Genome engineering in mouse models Contact: basile.tarchini@jax.org | Phone: (207) 288-6986 His laboratory at The Jackson Laboratory (Orono, Maine) explores single-cell and tissue-level patterning in auditory systems.

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Darryl Conteمشاهده پروفایل

دانشیار

University of Massachusetts Chan Medical SchoolUnited States

Darryl Conte is an Associate Professor at UMass Chan Medical School, holding positions in both the T.H. Chan School of Medicine and the Morningside Graduate School of Biomedical Sciences. He is a faculty member of the RNA Therapeutics Institute, where he conducts research focused on RNA biology and gene regulation mechanisms. Education BS in Mathematics from Rensselaer Polytechnic Institute, Troy, NY PhD in Biomedical Sciences from State University of New York, Albany, NY Dr. Conte's research primarily focuses on RNA interference pathways, particularly in the model organism Caenorhabditis elegans . His work has significantly advanced our understanding of small RNA pathways, including piRNA and siRNA mechanisms, epigenetic regulation, and genome surveillance systems. His laboratory investigates how these RNA-mediated processes control gene expression, maintain genome integrity, and influence developmental processes. Conte's research has revealed critical insights into how RNA silencing pathways function at the molecular level, with implications for understanding fundamental biological processes and potential therapeutic applications. Analysis of Dr. Conte's publication record shows a consistent focus on RNA biology, with particular emphasis on Argonaute proteins, piRNA pathways, and epigenetic regulation. His most highly cited works explore how small RNA pathways maintain germline integrity and mediate transgenerational epigenetic inheritance in C. elegans . The research demonstrates sophisticated molecular techniques including advanced sequencing methods and genetic approaches to dissect complex RNA regulatory networks. Dr. Conte has established himself as a leading researcher in the RNA interference field, with numerous publications in high-impact journals including Cell , Nature , and eLife . His work has been widely cited, with several publications exceeding 100 citations, indicating significant impact in the field of RNA biology and epigenetics. As a principal investigator, Dr. Conte mentors graduate students and postdoctoral researchers in the Morningside Graduate School of Biomedical Sciences and supervises research projects within the RNA Therapeutics Institute. His laboratory collaborates extensively with other researchers at UMass Chan Medical School, particularly with the laboratory of Dr. Craig Mello, Nobel laureate and pioneer in RNA interference research.

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Joe Mianoمشاهده پروفایل

استاد

Augusta UniversityUnited States

Joseph M. Miano, PhD, is a Professor at the Medical College of Georgia, Augusta University, where he holds the J. Harold Harrison, MD, Distinguished University Endowed Chair in Vascular Biology. He is a core faculty member of the Vascular Biology Center and serves in the Department of Medicine, Cardiology division. His academic appointment is firmly rooted in vascular and cardiovascular research, with a strong emphasis on molecular mechanisms in vascular smooth muscle cells. BS in Biology and Exercise Science, SUNY Cortland, 1986 PhD in Experimental Pathology, New York Medical College, 1992 Postdoctoral Training in Molecular Biology, UT MD Anderson Cancer Center, 1995 Dr. Miano's research focuses on the transcriptional and post-transcriptional regulation of gene expression in vascular biology. His primary interests include CRISPR and prime editing in rodents, smooth muscle cell differentiation, regulation of human ACE2 in mice, development of advanced mouse and rat models, and the function of coding and noncoding genes in vivo. His lab is known for generating innovative gene-edited rodent models to explore vascular smooth muscle pathobiology. His recent publications (2022–2024) highlight a strong trend in understanding long noncoding RNAs (lncRNAs) in vascular inflammation, CRISPR-based transgene mapping, and the role of the SRF-Myocardin switch in vascular disease. His work frequently appears in high-impact journals such as Circulation , Nature Cardiovascular Research , and Arteriosclerosis, Thrombosis, and Vascular Biology , reflecting sustained scholarly output and influence in cardiovascular science. J. Harold Harrison, MD, Distinguished University Endowed Chair in Vascular Biology Dr. Miano mentors graduate students and postdoctoral fellows, teaching courses such as VBIO 9300 (Research in Vascular Biology), VBIO 8020 (New Frontiers in Vascular Biology), and PHRM 8042 (Pharmacology & Therapeutics I). He has not listed specific grants in the provided text, but his extensive publication record and endowed chair suggest significant research funding. His laboratory, located in CL-3072, is an active hub for vascular biology research, contributing to the mission of the Vascular Biology Center at Augusta University.

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Donald McDonaldمشاهده پروفایل

استاد

University of California, San FranciscoUnited States

Donald McDonald, MD, PhD is a distinguished researcher at the University of California San Francisco (UCSF) School of Medicine. With over five decades of experience in vascular biology, he leads a laboratory focused on lymphangiogenesis, angiogenesis, and vascular remodeling in mouse models of chronic inflammation and cancer, particularly in the respiratory tract. Dr. McDonald received his A.B. in Zoology from the University of California, Berkeley in 1961, followed by his M.D. from UCSF in 1965. He completed his residency in Internal Medicine at the University of Iowa (1965-1966), pursued graduate studies in Cell Biology & Neuroscience at the NIH Graduate Division in Bethesda (1966-1969), and earned his Ph.D. in Cell Biology & Endocrinology from UCSF in 1974. Dr. McDonald's research examines how abnormalities in lymphatics and blood vessels contribute to disease pathophysiology, with current interests including developing approaches to prevent, stop, or reverse disease-related changes in these vessels. His laboratory uses mouse models to investigate the role of key growth factors and receptors such as VEGF-C, VEGF-A, angiopoietins, TNF-alpha, and HGF in vascular growth and remodeling. The research has significant implications for understanding and treating inflammatory diseases and cancer. Analysis of Dr. McDonald's recent publications reveals a consistent focus on lymphatic and blood vessel biology, with particular emphasis on their role in inflammation, cancer, and respiratory diseases. His work spans from basic cellular mechanisms to potential therapeutic applications, demonstrating a comprehensive approach to understanding vascular biology in health and disease. Dr. McDonald has been Principal Investigator on multiple NIH grants spanning several decades, including: Angiopoietin/Tie signaling regulation of vascular leakage in lung inflammation (R01HL143896, 2018-2022) Mechanisms, consequences, and reversal of abnormalities in lung lymphatics (R01HL127402, 2015-2019) Angiopoietins in vascular and lymphatic remodeling of airways and lung (R01HL059157, 1998-2017) Lymphangiogenesis and Angiogenesis in Airway Inflammation (R01HL096511, 2009-2010) He has also served as Co-Investigator on long-term NIH projects related to airway inflammation and pulmonary alveolar stability. Dr. McDonald's laboratory employs advanced in vivo cell biological approaches to manipulate signaling through switchable transgenic overexpression, genetic deletion, viral vectors, or pharmacological agents. His team investigates how growing or destroying lymphatics and blood vessels affects tumor growth, invasion, and metastasis, with the ultimate goal of developing strategies to stop or reverse pathological vascular changes.

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Florence Bareyreمشاهده پروفایل

استاد

Ludwig Maximilian University of MunichGermany

Prof. Dr. Florence Bareyre is a leading Professor at the Biomedical Center, Ludwig-Maximilians-Universität München, and principal investigator of the "Spinal Cord Repair" research group. With over 20 years of experience in neurotrauma research, she has made groundbreaking contributions to understanding axonal plasticity and spinal circuit remodeling after CNS injury. Her work demonstrates how detour circuits mediate recovery and how neuronal activity and molecular interventions like FGF22 therapy enhance functional restoration. Bachelor Biochemistry, University Paris VII (1992–1994) Master Biochemistry, University Paris VII (1994–1996) Ph.D., ETH Zurich (2003) Research interests focus on spinal cord injury , axonal plasticity , neuroimmunology , and gene therapy . Her lab uses in vivo imaging , genetic manipulations , and electrophysiological recordings to study detour circuit formation and activity-dependent plasticity. Recent publications highlight microglia's role in synapse engulfment, metabolic interventions for axonal energy deficits, and neurostimulation strategies. Key article trends include neuroimmunological mechanisms after trauma, molecular therapies for synaptic regeneration, and neurostimulation approaches to unlock recovery. Her work bridges Cellular Neuroscience , Molecular Neurobiology , and Clinical Neuroimmunology . Dissertation Medal of Excellence, ETH Zürich (2003) EMBO long-term fellowship (2005–2007) Sobek junior prize (2007) BMBF Independent group leader award (2008–2014) Leading a diverse team including PhD students and technical assistants , she advises researchers like Fritz Kagerer and Adna Smajkan . Current projects investigate microglia-neuron interactions , Netrin signaling , and age-dependent recovery signals . Funding comes from DFG, SyNergy, Wings for Life, and FOR5705 Neuroflame.

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Uwe Maskosمشاهده پروفایل

استاد

Pasteur InstituteFrance

Uwe Maskos is a Professor and Head of the Laboratory of Integrative Neurobiology of Cholinergic Systems at the Department of Neuroscience, Institut Pasteur, Paris. His research focuses on the role of nicotinic acetylcholine receptors (nAChRs) in neuropsychiatric and neurodegenerative disorders, including addiction, schizophrenia, and Alzheimer's disease. Institution: Institut Pasteur School: Department of Neuroscience Department: Integrative Neurobiology of Cholinergic Systems Email: uwe.maskos@pasteur.fr His research integrates molecular genetics, animal models, and human stem cell-derived neurons to understand the mechanisms underlying vulnerability to mental disorders and neurodegeneration. Key areas include the impact of CHRNA5 polymorphisms on nicotine and alcohol addiction, the role of nAChRs in hypofrontality in schizophrenia, and the protective effects of receptor modulation in Alzheimer's pathology. His work also extends to non-neuronal roles of nAChRs in lung cancer and COPD. The recent publications reflect a strong trend in translational neuroscience, combining genetic models (transgenic mice and rats), advanced imaging (two-photon microscopy), and human iPSC technology to dissect the function of nAChR subunits in health and disease. Subfields include synaptic physiology, behavioral pharmacology, neuroinflammation, structural biology of receptors, and precision medicine approaches. Dr. Maskos leads multiple funded projects and collaborates across disciplines, though specific scientific awards and student advisees are not listed in the provided text. His laboratory is actively involved in major initiatives such as the IP Stem Cell Initiative and research on the gut-brain axis.

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Raymond J. Picklesمشاهده پروفایل

دانشیار

University of North Carolina at Chapel HillUnited States

Dr. Raymond J. Pickles is an Associate Professor in the Department of Microbiology and Immunology at the University of North Carolina at Chapel Hill School of Medicine. He maintains dual primary affiliations with the UNC Cystic Fibrosis/Pulmonary Research and Treatment Center and the UNC Human Gene Therapy Center, where he leads a research laboratory focused on respiratory virus infections and their implications for patients with cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). His laboratory is physically located in Marsico Hall at UNC Chapel Hill, within the Cystic Fibrosis/Pulmonary Research and Treatment Center. Dr. Pickles earned his PhD from the University of Cambridge, establishing a foundation for his research career that has spanned decades in respiratory virology and airway biology. His academic journey has led him to become a recognized expert in the field of respiratory viral pathogenesis and therapeutic development for lung diseases. Dr. Pickles' research program centers on understanding how common respiratory viruses infect the human lung, with particular emphasis on cell-type tropism and innate immune factors that influence viral pathogenesis. His laboratory has three major research goals related to CF lung disease: developing strategies to deliver therapeutic transgenes to human airways (particularly for CFTR delivery to CF patients), understanding the role of ciliated airway epithelial cells in respiratory virus infection, and studying innate defense mechanisms provided by these cells. He focuses on three common respiratory viral pathogens: respiratory syncytial virus (RSV), parainfluenza viruses (PIV), and influenza viruses, which are among the most common causes of viral infections in infants and children, and pose significant risks to individuals with compromised lungs. His work has expanded to include SARS-CoV-2 research during the pandemic, examining viral pathogenesis and potential therapeutic interventions. Dr. Pickles' publication record demonstrates consistent productivity from 2011 through 2025, with a clear trajectory from fundamental virology studies toward translational applications. His recent work (2023-2025) shows increased focus on advanced airway epithelium models, humanized animal models for viral infection, and novel therapeutic approaches including monoclonal antibodies and gene therapy strategies. The integration of computational modeling with experimental approaches represents a growing aspect of his research program, particularly evident in his SARS-CoV-2 related publications. Dr. Pickles maintains extensive collaborations across multiple disciplines as evidenced by his co-authorship patterns, working with researchers in pulmonology, immunology, gene therapy, and computational biology. His laboratory bridges basic science with clinical applications, particularly in developing novel approaches to treat respiratory viral infections in vulnerable patient populations with underlying lung diseases.

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James Hewettمشاهده پروفایل

دانشیار

Syracuse UniversityUnited States

James Hewett is an Associate Professor in the Department of Biology at Syracuse University's College of Arts and Sciences, serving as Executive Director of Neuroscience Studies and Director of the Neuroscience Graduate Concentration. Research focuses on neuromodulatory mechanisms in neurological disorders, particularly epilepsy. Key investigations include: Role of cyclooxygenase-2 in seizure suppression Interleukin-1β signaling in neuronal hyperexcitability TIA-1 RNA binding protein in epileptogenesis Neuroinflammatory pathways following brain injury Laboratory utilizes transgenic mouse models, electrophysiology, molecular biology, and neuropharmacological approaches to identify novel therapeutic targets for epilepsy. The 2022 Neurobiology of Disease publication demonstrates constitutive IL-1β release in hippocampal neurons, suggesting homeostatic neuromodulatory functions. Currently investigating system xc- transporter roles in glutamate/glutathione homeostasis. Teaches Principles of Human Toxicology, Pharmacology of Substance Abuse, and mentors graduate neuroscience students. Secured NIH/NINDS funding for epilepsy research mechanisms.

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