معرفی
Uwe Maskos is a Professor and Head of the Laboratory of Integrative Neurobiology of Cholinergic Systems at the Department of Neuroscience, Institut Pasteur, Paris. His research focuses on the role of nicotinic acetylcholine receptors (nAChRs) in neuropsychiatric and neurodegenerative disorders, including addiction, schizophrenia, and Alzheimer's disease.
- Institution: Institut Pasteur
- School: Department of Neuroscience
- Department: Integrative Neurobiology of Cholinergic Systems
- Email: uwe.maskos@pasteur.fr
His research integrates molecular genetics, animal models, and human stem cell-derived neurons to understand the mechanisms underlying vulnerability to mental disorders and neurodegeneration. Key areas include the impact of CHRNA5 polymorphisms on nicotine and alcohol addiction, the role of nAChRs in hypofrontality in schizophrenia, and the protective effects of receptor modulation in Alzheimer's pathology. His work also extends to non-neuronal roles of nAChRs in lung cancer and COPD.
The recent publications reflect a strong trend in translational neuroscience, combining genetic models (transgenic mice and rats), advanced imaging (two-photon microscopy), and human iPSC technology to dissect the function of nAChR subunits in health and disease. Subfields include synaptic physiology, behavioral pharmacology, neuroinflammation, structural biology of receptors, and precision medicine approaches.
Dr. Maskos leads multiple funded projects and collaborates across disciplines, though specific scientific awards and student advisees are not listed in the provided text. His laboratory is actively involved in major initiatives such as the IP Stem Cell Initiative and research on the gut-brain axis.
