معرفی
Pierre-Jean Corringer is a permanent researcher and Head of Structure in the Signaling and Receptors Dynamics unit at the Institut Pasteur, affiliated with the Department of Neuroscience. He leads multiple research projects as Principal Investigator and is actively involved in structural and functional studies of pentameric ligand-gated ion channels, particularly nicotinic acetylcholine receptors (nAChRs).
- Institut Pasteur, Paris
- Department of Neuroscience
- Signaling and Receptors Dynamics Unit
Research Interests: His work focuses on understanding the atomic-level mechanisms of ion channel function and their modulation by drugs and toxins. He employs a multidisciplinary approach integrating cryo-electron microscopy, electrophysiology, protein engineering, and fluorescence techniques to study receptor dynamics and design novel therapeutics.
The recent publications highlight a strong trend in structural neurobiology, particularly in elucidating allosteric mechanisms in ligand-gated ion channels such as nAChRs, 5-HT3, and glycine receptors. His team utilizes cutting-edge techniques like voltage-clamp fluorometry and nanobody-based modulation to probe conformational changes and develop targeted therapies.
Scientific Awards:
- No awards explicitly mentioned in the provided text.
Advising and Grants: Dr. Corringer mentors several PhD students and postdoctoral researchers. He is Principal Investigator for multiple funded projects including ERC Advanced DYNACOTINE, ANR-Pentacontrol, HBP-CDP6, and ANR-Nicofive, indicating significant grant acquisition and leadership in drug discovery and receptor dynamics research.
Labs and Teams: He leads the structural research within the Signaling and Receptors Dynamics group, collaborating closely with Nicolas Wolff and other team members. His lab is at the forefront of combining structural biology with functional assays to understand and modulate neuronal receptors involved in addiction and neurological diseases.
